Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
Citations
More filters
Journal ArticleDOI
The role of post-translational modifications in synaptic AMPA receptor activity
TL;DR: In this article , the diversity of mechanisms involved in post-translational modification of AMPA receptor subunits, and their impact on the subcellular distribution and synaptic activity of the receptors are discussed.
Dissertation
The Role of αSAP97 and βSAP97 at the Glutamatergic Synapse
TL;DR: The scaffolding of synapse-associated protein-97 isoforms scaffold synaptic and extrasynaptic receptors and their role in receptor recycling and recycling are illustrated.
Journal ArticleDOI
Regulation of AMPAR expression by microRNAs.
TL;DR: A review of miRNAs that have been identified as playing a role in physiological or pathological changes in AMPAR subunit expression at synapses, focussing on miRNA that target mRNAs encoding AMPAR, and on miRNA that target AMPAR accessory proteins involved in amPAR trafficking and hence the regulation of AMPAR synaptic localisation can be found in this article.
Journal ArticleDOI
PKA-Dependent Membrane Surface Recruitment of CI-AMPARs Is Crucial for BCP-Mediated Protection Against Post-acute Ischemic Stroke Cognitive Impairment.
TL;DR: In this article, a 60-min temporary middle cerebral artery occlusion (MCAO) model was established to simulate the pathology of acute ischemic stroke and β-Caryophyllene (BCP) was used to study the role of BCP in MCAO mice.
The role of DHHC5-mediated palmitoylation of delta-catenin in cadherin stability and synapse plasticity
TL;DR: This work presents a meta-analysis of the role of canine coronavirus in the development of neurological disease and its role in DHHC Proteins in Cognitive Function and Neurological Disease using a model system based on the Hippocampus.
References
More filters
Journal Article
The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
Journal ArticleDOI
Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
Journal ArticleDOI
AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
Journal ArticleDOI
Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
Journal ArticleDOI
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.