Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Wei Lu,Yun Shi,Alexander C. Jackson,Kirsten Bjorgan,Matthew J. During,Rolf Sprengel,Peter H. Seeburg,Roger A. Nicoll +7 more
TLDR
A functional quantification of the subunit composition of AMPARs in the CNS is provided and novel roles for AMPAR subunits in receptor trafficking are suggested and suggested.About:
This article is published in Neuron.The article was published on 2009-04-30 and is currently open access. It has received 605 citations till now. The article focuses on the topics: Silent synapse & Long-term depression.read more
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Distance-Dependent Scaling of AMPARs Is Cell-Autonomous and GluA2 Dependent
TL;DR: Using dendritic recordings from rat pyramidal neurons, this work confirms the basic scaling phenomenon and finds that it is expressed and can be manipulated cell autonomously and shows that it depends on the presence of both a reserve pool of AMPARs and the AMPAR subunit GluA2.
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Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease.
TL;DR: Key factors that regulate the structure and dynamics of the actin cytoskeleton, the major cytoskeletal building block that supports the postsynaptic compartment, are discussed, with a particular focus on Alzheimer's disease pathology.
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Mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex.
Marcus S Dyer,Laura A Reale,Katherine E. Lewis,Adam K. Walker,Tracey C. Dickson,Adele Woodhouse,Catherine A. Blizzard +6 more
TL;DR: It is provided the first evidence that TDP‐43 mislocalisation causes aberrant synaptic function and a hyperexcitability phenotype in the motor cortex, linking some of the earliest dysfunctions to arise in people with ALS to mis localisation of T DP‐43.
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Relationship Between Synaptic AMPAR and Spine Dynamics: Impairments in the FXS Mouse.
Anand Suresh,Anna Dunaevsky +1 more
TL;DR: It is demonstrated that AMPAR levels within spines not are only continuously dynamic, but are also predictive of spine behavior, with impairments observed in the fmr1 KO mice.
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AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs
TL;DR: In this paper, an updated AMPAR trafficking and LTP model was proposed, which incorporates both extracellular as well as intracellular mechanisms, based on recent research reviewed in this special issue on AMPA receptors.
References
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Journal Article
The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
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Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
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AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
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Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Yasunori Hayashi,Song-Hai Shi,José A. Esteban,Antonella Piccini,Jean Christophe Poncer,Roberto Malinow +5 more
TL;DR: Results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
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RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.