Journal ArticleDOI
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
Keertan Dheda,Tawanda Gumbo,Gary Maartens,Kelly E. Dooley,Ruth McNerney,Megan Murray,Jennifer Furin,Edward A. Nardell,Leslie London,Erica Lessem,Grant Theron,Paul D. van Helden,Stefan Niemann,Matthias Merker,David W. Dowdy,Annelies Van Rie,Annelies Van Rie,Gilman Kit Hang Siu,Jotam G. Pasipanodya,Camilla Rodrigues,Taane G. Clark,F. A. Sirgel,Aliasgar Esmail,Hsien-Ho Lin,Sachin R Atre,H. Simon Schaaf,Kwok Chiu Chang,Christoph Lange,Payam Nahid,Zarir F Udwadia,C. Robert Horsburgh,Gavin J. Churchyard,Gavin J. Churchyard,Dick Menzies,Anneke C. Hesseling,Eric L. Nuermberger,Helen McIlleron,Kevin P. Fennelly,Eric Goemaere,Ernesto Jaramillo,Marcus Low,Carolina Morán Jara,Nesri Padayatchi,Robin M. Warren +43 more
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TLDR
Several lines of evidence suggest that alternative mechanisms-including pharmacokinetic variability, induction of efflux pumps that transport the drug out of cells, and suboptimal drug penetration into tuberculosis lesions-are likely crucial to the pathogenesis of drug-resistant tuberculosis.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2017-04-01. It has received 461 citations till now. The article focuses on the topics: Bedaquiline & Delamanid.read more
Citations
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Journal ArticleDOI
Incipient and Subclinical Tuberculosis: a Clinical Review of Early Stages and Progression of Infection.
Paul K. Drain,Kristina L. Bajema,David W. Dowdy,Keertan Dheda,Kogieleum Naidoo,Samuel G Schumacher,Shuyi Ma,Shuyi Ma,Erin W. Meermeier,David M. Lewinsohn,David R. Sherman,David R. Sherman +11 more
TL;DR: Current understanding of the pathogenesis, immunology, clinical epidemiology, diagnosis, treatment, and prevention of both incipient and subclinical TB, two emerging clinical states of an ancient bacterium are reviewed.
Journal ArticleDOI
A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis
Paolo Miotto,Belay Tessema,Elisa Tagliani,Leonid Chindelevitch,Angela M. Starks,Claudia Emerson,Debra Hanna,Peter S. Kim,Richard Liwski,Matteo Zignol,Christopher Gilpin,Stefan Niemann,Claudia M. Denkinger,Joy Fleming,Robin M. Warren,Derrick W. Crook,Derrick W. Crook,James E. Posey,Sebastien Gagneux,Sebastien Gagneux,Sven Hoffner,Sven Hoffner,Camilla Rodrigues,Iñaki Comas,David M. Engelthaler,Megan Murray,David Alland,Leen Rigouts,Christoph Lange,Keertan Dheda,Rumina Hasan,Uma Devi Ranganathan,Ruth McNerney,Matthew Ezewudo,Daniela Maria Cirillo,Marco Schito,Claudio U. Köser,Timothy C. Rodwell,Timothy C. Rodwell +38 more
TL;DR: This study provides a standardised and comprehensive approach for the interpretation of mutations as predictors of M. tuberculosis drug- resistant phenotypes and has implications for the clinical interpretation of molecular diagnostics and next-generation sequencing as well as efficient individualised therapy for patients with drug-resistant tuberculosis.
Journal ArticleDOI
Phase 2b Controlled Trial of M72/AS01E Vaccine to Prevent Tuberculosis
Olivier Van Der Meeren,Mark Hatherill,Videlis Nduba,Robert J. Wilkinson,Monde Muyoyeta,Elana van Brakel,Helen Ayles,German Henostroza,Friedrich Thienemann,Thomas J. Scriba,Andreas H. Diacon,Gretta L Blatner,Marie-Ange Demoitié,Michele Tameris,Mookho Malahleha,James C Innes,Elizabeth Hellstrom,Neil A. Martinson,Tina Singh,Elaine J Akite,Aisha Khatoon Azam,Anne Bollaerts,Ann M. Ginsberg,Thomas G. Evans,Paul Gillard,Dereck Tait +25 more
TL;DR: M72/AS01E provided 54.0% protection for M. tuberculosis–infected adults against active pulmonary tuberculosis disease, without evident safety concerns, in a phase 2b trial in Kenya, South Africa, and Zambia.
Journal ArticleDOI
Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies
Simon Tiberi,Nelita du Plessis,Gerhard Walzl,Michael J. Vjecha,Martin Rao,Francine Ntoumi,Sayoki Mfinanga,Nathan Kapata,Peter Mwaba,Timothy D. McHugh,Giuseppe Ippolito,Giovanni Battista Migliori,Markus Maeurer,Alimuddin Zumla +13 more
TL;DR: The developmental pipeline and landscape of new and repurposed tuberculosis drugs, treatment regimens, and host-directed therapies (HDTs) for drug-sensitive and drug-resistant tuberculosis are reviewed and a range of HDTs and immune-based treatments are under investigation as adjunctive therapy.
Journal ArticleDOI
Evolution of drug resistance in Mycobacterium tuberculosis: a review on the molecular determinants of resistance and implications for personalized care
Navisha Dookie,Santhuri Rambaran,Nesri Padayatchi,Nesri Padayatchi,Sharana Mahomed,Kogieleum Naidoo,Kogieleum Naidoo +6 more
TL;DR: Advances in sequencing technology will help devise better molecular diagnostics for more effective DR-TB management enabling personalized treatment, and will facilitate the development of new drugs aimed at improving outcomes of patients with this disease.
References
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Journal ArticleDOI
Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
Francesc Coll,Ruth McNerney,Mark D. Preston,José Afonso Guerra-Assunção,Andrew Warry,Grant A. Hill-Cawthorne,Grant A. Hill-Cawthorne,Kim Mallard,Mridul Nair,Anabela Miranda,Adriana Alves,João Perdigão,Miguel Viveiros,Isabel Portugal,Zahra Hasan,Rumina Hasan,Judith R. Glynn,Nigel Martin,Arnab Pain,Taane G. Clark +19 more
TL;DR: A library predictive of DR for 15 anti-tuberculosis drugs was compiled and validated for 11 of them using genomic-phenotypic data from 792 strains, and in silico diagnostic accuracy was superior to some commercial diagnostics and alternative databases.
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How drug resistance emerges as a result of poor compliance during short course chemotherapy for tuberculosis.
TL;DR: Four theoretical mechanisms by which drug resistance might arise as a result of poor compliance during short course chemotherapy are explored and an explanation for mono-resistance to rifampicin in patients with the acquired immune deficiency syndrome (AIDS).
Journal ArticleDOI
Infectiousness of air from a tuberculosis ward. Ultraviolet irradiation of infected air: comparative infectiousness of different patients.
Journal ArticleDOI
Modeling epidemics of multidrug-resistant M. tuberculosis of heterogeneous fitness
Ted Cohen,Megan Murray +1 more
TL;DR: It is found that even when the average relative fitness of MDR strains is low and a well-functioning control program is in place, a small subpopulation of a relatively fit MDR strain may eventually outcompete both the drug-sensitive strains and the less fit M DR strains.
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Transmission of tubercle bacilli: The effects of chemotherapy.
TL;DR: The future reduction of transmission will essentially depend on the maintenance of an adequate system ensuring the early diagnosis and correct treatment of cases, which will inevitably continue to appear among the already infected portion of the population.
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