Journal ArticleDOI
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
Keertan Dheda,Tawanda Gumbo,Gary Maartens,Kelly E. Dooley,Ruth McNerney,Megan Murray,Jennifer Furin,Edward A. Nardell,Leslie London,Erica Lessem,Grant Theron,Paul D. van Helden,Stefan Niemann,Matthias Merker,David W. Dowdy,Annelies Van Rie,Annelies Van Rie,Gilman Kit Hang Siu,Jotam G. Pasipanodya,Camilla Rodrigues,Taane G. Clark,F. A. Sirgel,Aliasgar Esmail,Hsien-Ho Lin,Sachin R Atre,H. Simon Schaaf,Kwok Chiu Chang,Christoph Lange,Payam Nahid,Zarir F Udwadia,C. Robert Horsburgh,Gavin J. Churchyard,Gavin J. Churchyard,Dick Menzies,Anneke C. Hesseling,Eric L. Nuermberger,Helen McIlleron,Kevin P. Fennelly,Eric Goemaere,Ernesto Jaramillo,Marcus Low,Carolina Morán Jara,Nesri Padayatchi,Robin M. Warren +43 more
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TLDR
Several lines of evidence suggest that alternative mechanisms-including pharmacokinetic variability, induction of efflux pumps that transport the drug out of cells, and suboptimal drug penetration into tuberculosis lesions-are likely crucial to the pathogenesis of drug-resistant tuberculosis.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2017-04-01. It has received 461 citations till now. The article focuses on the topics: Bedaquiline & Delamanid.read more
Citations
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Journal ArticleDOI
Incipient and Subclinical Tuberculosis: a Clinical Review of Early Stages and Progression of Infection.
Paul K. Drain,Kristina L. Bajema,David W. Dowdy,Keertan Dheda,Kogieleum Naidoo,Samuel G Schumacher,Shuyi Ma,Shuyi Ma,Erin W. Meermeier,David M. Lewinsohn,David R. Sherman,David R. Sherman +11 more
TL;DR: Current understanding of the pathogenesis, immunology, clinical epidemiology, diagnosis, treatment, and prevention of both incipient and subclinical TB, two emerging clinical states of an ancient bacterium are reviewed.
Journal ArticleDOI
A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis
Paolo Miotto,Belay Tessema,Elisa Tagliani,Leonid Chindelevitch,Angela M. Starks,Claudia Emerson,Debra Hanna,Peter S. Kim,Richard Liwski,Matteo Zignol,Christopher Gilpin,Stefan Niemann,Claudia M. Denkinger,Joy Fleming,Robin M. Warren,Derrick W. Crook,Derrick W. Crook,James E. Posey,Sebastien Gagneux,Sebastien Gagneux,Sven Hoffner,Sven Hoffner,Camilla Rodrigues,Iñaki Comas,David M. Engelthaler,Megan Murray,David Alland,Leen Rigouts,Christoph Lange,Keertan Dheda,Rumina Hasan,Uma Devi Ranganathan,Ruth McNerney,Matthew Ezewudo,Daniela Maria Cirillo,Marco Schito,Claudio U. Köser,Timothy C. Rodwell,Timothy C. Rodwell +38 more
TL;DR: This study provides a standardised and comprehensive approach for the interpretation of mutations as predictors of M. tuberculosis drug- resistant phenotypes and has implications for the clinical interpretation of molecular diagnostics and next-generation sequencing as well as efficient individualised therapy for patients with drug-resistant tuberculosis.
Journal ArticleDOI
Phase 2b Controlled Trial of M72/AS01E Vaccine to Prevent Tuberculosis
Olivier Van Der Meeren,Mark Hatherill,Videlis Nduba,Robert J. Wilkinson,Monde Muyoyeta,Elana van Brakel,Helen Ayles,German Henostroza,Friedrich Thienemann,Thomas J. Scriba,Andreas H. Diacon,Gretta L Blatner,Marie-Ange Demoitié,Michele Tameris,Mookho Malahleha,James C Innes,Elizabeth Hellstrom,Neil A. Martinson,Tina Singh,Elaine J Akite,Aisha Khatoon Azam,Anne Bollaerts,Ann M. Ginsberg,Thomas G. Evans,Paul Gillard,Dereck Tait +25 more
TL;DR: M72/AS01E provided 54.0% protection for M. tuberculosis–infected adults against active pulmonary tuberculosis disease, without evident safety concerns, in a phase 2b trial in Kenya, South Africa, and Zambia.
Journal ArticleDOI
Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies
Simon Tiberi,Nelita du Plessis,Gerhard Walzl,Michael J. Vjecha,Martin Rao,Francine Ntoumi,Sayoki Mfinanga,Nathan Kapata,Peter Mwaba,Timothy D. McHugh,Giuseppe Ippolito,Giovanni Battista Migliori,Markus Maeurer,Alimuddin Zumla +13 more
TL;DR: The developmental pipeline and landscape of new and repurposed tuberculosis drugs, treatment regimens, and host-directed therapies (HDTs) for drug-sensitive and drug-resistant tuberculosis are reviewed and a range of HDTs and immune-based treatments are under investigation as adjunctive therapy.
Journal ArticleDOI
Evolution of drug resistance in Mycobacterium tuberculosis: a review on the molecular determinants of resistance and implications for personalized care
Navisha Dookie,Santhuri Rambaran,Nesri Padayatchi,Nesri Padayatchi,Sharana Mahomed,Kogieleum Naidoo,Kogieleum Naidoo +6 more
TL;DR: Advances in sequencing technology will help devise better molecular diagnostics for more effective DR-TB management enabling personalized treatment, and will facilitate the development of new drugs aimed at improving outcomes of patients with this disease.
References
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Journal ArticleDOI
WHO Group 5 Drugs and Difficult Multidrug-Resistant Tuberculosis: a Systematic Review with Cohort Analysis and Meta-Analysis
TL;DR: The findings substantiated the use of linezolid in the treatment of XDR- TB or fluoroquinolone-resistant MDR-TB and call for further studies to evaluate the roles of other group 5 drugs.
Journal ArticleDOI
Pharmacokinetics and Pharmacodynamics of Clofazimine in a Mouse Model of Tuberculosis
Rosemary V. Swanson,John H. Adamson,Chivonne Moodley,Bongani Ngcobo,Nicole C. Ammerman,Afton Dorasamy,Sashen Moodley,Zinhle Mgaga,Asa Tapley,Linda A. Bester,Sanil D. Singh,Jacques H. Grosset,Jacques H. Grosset,Deepak V. Almeida,Deepak V. Almeida +14 more
TL;DR: The antituberculosis activity of clofazimine was dependent on neither the dose administered nor the drug concentrations in the tissues, suggesting that much lower doses could be effectively used for tuberculosis treatment.
Journal ArticleDOI
Institutional Tuberculosis Transmission. Controlled Trial of Upper Room Ultraviolet Air Disinfection: A Basis for New Dosing Guidelines.
Matsie Mphaphlele,Ashwin S. Dharmadhikari,Paul A. Jensen,Stephen N. Rudnick,Tobias H Van Reenen,Marcello Pagano,Wilhelm Leuschner,Tim A. Sears,Sonya P. Milonova,Martie van der Walt,Anton Stoltz,Karin Weyer,Edward A. Nardell +12 more
TL;DR: Upper room germicidal UV air disinfection with air mixing was highly effective in reducing tuberculosis transmission under hospital conditions.
Journal ArticleDOI
In vitro activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis.
Lucio Vera-Cabrera,Eva Gonzalez,Adrian Rendon,Jorge Ocampo-Candiani,Oliverio Welsh,Victor M. Velazquez-Moreno,Sung Hak Choi,Carmen A. Molina-Torres +7 more
TL;DR: The in vitro activities of DA-7157, a novel oxazolidinone, against clinical isolates of Nocardia brasiliensis and Mycobacterium tuberculosis were determined and the prodrug, DA-7218, exhibited similar MICs for M. tuberculosis but fivefold-higherMICs for N. brasiliense.
Journal ArticleDOI
Variability in the population pharmacokinetics of pyrazinamide in South African tuberculosis patients
Justin J. Wilkins,Justin J. Wilkins,Grant Langdon,Grant Langdon,Helen McIlleron,Helen McIlleron,Goonaseelan Pillai,Pete Smith,Ulrika S. H. Simonsson +8 more
TL;DR: The absorption of pyrazinamide in the studied population was highly variable and two separate subpopulations were identified, and IOV accounted for a proportion of the variability in clearance and the absorption rate constant.
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