Journal ArticleDOI
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
Keertan Dheda,Tawanda Gumbo,Gary Maartens,Kelly E. Dooley,Ruth McNerney,Megan Murray,Jennifer Furin,Edward A. Nardell,Leslie London,Erica Lessem,Grant Theron,Paul D. van Helden,Stefan Niemann,Matthias Merker,David W. Dowdy,Annelies Van Rie,Annelies Van Rie,Gilman Kit Hang Siu,Jotam G. Pasipanodya,Camilla Rodrigues,Taane G. Clark,F. A. Sirgel,Aliasgar Esmail,Hsien-Ho Lin,Sachin R Atre,H. Simon Schaaf,Kwok Chiu Chang,Christoph Lange,Payam Nahid,Zarir F Udwadia,C. Robert Horsburgh,Gavin J. Churchyard,Gavin J. Churchyard,Dick Menzies,Anneke C. Hesseling,Eric L. Nuermberger,Helen McIlleron,Kevin P. Fennelly,Eric Goemaere,Ernesto Jaramillo,Marcus Low,Carolina Morán Jara,Nesri Padayatchi,Robin M. Warren +43 more
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TLDR
Several lines of evidence suggest that alternative mechanisms-including pharmacokinetic variability, induction of efflux pumps that transport the drug out of cells, and suboptimal drug penetration into tuberculosis lesions-are likely crucial to the pathogenesis of drug-resistant tuberculosis.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2017-04-01. It has received 461 citations till now. The article focuses on the topics: Bedaquiline & Delamanid.read more
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Journal ArticleDOI
Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1.
Rosanne Persaud,Sheena C. Li,Joseph D. Chao,Roberto Forestieri,Elizabeth Donohue,Aruna D. Balgi,Xingji Zheng,Jesse T. Chao,Yoko Yashiroda,Mami Yoshimura,Christopher J. R. Loewen,Anne-Claude Gingras,Charles Boone,Yossef Av-Gay,Michel Roberge,Raymond J. Andersen +15 more
TL;DR: In this article, the authors show that the marine natural product clionamines activate autophagy and inhibit Mtb survival in macrophages, and they identify the target protein of the clionamine as a human homolog of Pik1.
Journal ArticleDOI
Performance Comparison of GeneXpert MTB/RIF and ProbeTec ET Tests for Rapid Molecular Diagnosis of Extrapulmonary Tuberculosis in a Low TB/MDR-TB Incidence Country.
TL;DR: In this paper, the performance of GeneXpert MTB/RIF (Xpert) and ProbeTec ET (PTec-ET) assays was evaluated in diagnosing extrapulmonary tuberculosis (EPTB) in Kuwait.
Journal ArticleDOI
The Roles of Chemokines in Immune Response to Mycobacterial Infection
TL;DR: The roles and mechanisms by which chemokines and their receptors are involved in both host immune protection and pathology during TB infection are focused.
Journal ArticleDOI
In vitro activity of bedaquiline against Mycobacterium avium complex.
TL;DR: In this paper, the minimum inhibitory concentrations (MICs) of Bdq for M. avium and M. intracellulare were obtained by twofold serial dilutions in the Middlebrook 7H9 medium.
Journal ArticleDOI
Potency of vancomycin against Mycobacterium tuberculosis in the hollow fiber system model.
Shashikant Srivastava,Shashikant Srivastava,Moti L. Chapagain,Johanna S. van Zyl,Devyani Deshpande,Tawanda Gumbo,Tawanda Gumbo +6 more
TL;DR: In this article, vancomycin was shown to be antagonistic to benzylpenicillin, which works downstream to glycopeptides in peptidoglycan synthesis, but synergistic with d -cycloserine, which inhibits upstream d-Ala-d -Ala ligase and alanine racemase.
References
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Journal ArticleDOI
Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology.
Judith Kamerbeek,Leo M. Schouls,Arend H. J. Kolk,M van Agterveld,D. van Soolingen,Sjoukje Kuijper,Annelies Bunschoten,H Molhuizen,R J Shaw,M Goyal,J. D. A. Van Embden +10 more
TL;DR: A novel method based on strain-dependent hybridization patterns of in vitro-amplified DNA with multiple spacer oligonucleotides was found to differentiate M. bovis from M. tuberculosis, a distinction which is often difficult to make by traditional methods.
Journal ArticleDOI
Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology.
J. D. A. Van Embden,M. D. Cave,Jack T. Crawford,J. W. Dale,K. D. Eisenach,B Gicquel,Peter W. M. Hermans,Carlos Martin,R. A. Mcadam,Thomas M. Shinnick +9 more
TL;DR: In this article, the authors proposed a standardized technique which exploits variability in both the number and genomic position of IS6110 to generate strain-specific patterns for DNA fingerprinting of Mycobacterium tuberculosis.
Journal ArticleDOI
Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children
Gregory L. Kearns,Susan M. Abdel-Rahman,Sarah W. Alander,Douglas L. Blowey,J. Steven Leeder,Ralph E. Kauffman +5 more
TL;DR: This review examines the developmental changes that profoundly affect the responses of children to medications and related therapies in the very young.
Journal ArticleDOI
Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa
Neel R. Gandhi,Neel R. Gandhi,Anthony P. Moll,A. Willem Sturm,Robert Pawinski,Thiloshini Govender,Umesh G. Lalloo,Kimberly Zeller,Kimberly Zeller,Jason R. Andrews,Gerald Friedland +10 more
TL;DR: MDR tuberculosis is more prevalent than previously realised in a rural area in KwaZulu Natal, South Africa and has been transmitted to HIV co-infected patients and is associated with high mortality.
Journal ArticleDOI
Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis
Amalio Telenti,P Imboden,F Marchesi,Lukas Matter,K Schopfer,Thomas Bodmer,Douglas B. Lowrie,M.J Colston,Stewart T. Cole +8 more
TL;DR: Substitution of a limited number of highly conserved aminoacids encoded by the rpoB gene appears to be the molecular mechanism responsible for "single step" high-level resistance to rifampicin in M tuberculosis, a marker of multidrug-resistant tuberculosis.
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