Journal ArticleDOI
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
Keertan Dheda,Tawanda Gumbo,Gary Maartens,Kelly E. Dooley,Ruth McNerney,Megan Murray,Jennifer Furin,Edward A. Nardell,Leslie London,Erica Lessem,Grant Theron,Paul D. van Helden,Stefan Niemann,Matthias Merker,David W. Dowdy,Annelies Van Rie,Annelies Van Rie,Gilman Kit Hang Siu,Jotam G. Pasipanodya,Camilla Rodrigues,Taane G. Clark,F. A. Sirgel,Aliasgar Esmail,Hsien-Ho Lin,Sachin R Atre,H. Simon Schaaf,Kwok Chiu Chang,Christoph Lange,Payam Nahid,Zarir F Udwadia,C. Robert Horsburgh,Gavin J. Churchyard,Gavin J. Churchyard,Dick Menzies,Anneke C. Hesseling,Eric L. Nuermberger,Helen McIlleron,Kevin P. Fennelly,Eric Goemaere,Ernesto Jaramillo,Marcus Low,Carolina Morán Jara,Nesri Padayatchi,Robin M. Warren +43 more
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TLDR
Several lines of evidence suggest that alternative mechanisms-including pharmacokinetic variability, induction of efflux pumps that transport the drug out of cells, and suboptimal drug penetration into tuberculosis lesions-are likely crucial to the pathogenesis of drug-resistant tuberculosis.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2017-04-01. It has received 461 citations till now. The article focuses on the topics: Bedaquiline & Delamanid.read more
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Journal ArticleDOI
Next-Generation Sequencing for Characterizing Drug Resistance-Conferring Mycobacterium tuberculosis Genes from Clinical Isolates in the Ukraine.
Luke T. Daum,Olha Konstantynovska,O. S. Solodiankin,Oleksandr Liashenko,Petro Poteiko,V. Bolotin,Ivan Hrek,Anton Rohozhyn,John D. Rodriguez,Gerald W. Fischer,James P. Chambers,Anton Gerilovych +11 more
TL;DR: This is the first study to use next-generation sequencing (NGS) of clinical isolates from the Ukraine to characterize mutations in genes conferring M. tuberculosis drug resistance, providing a broader understanding of MDR/XDR from this area of the world.
Journal ArticleDOI
Genomic prediction of tuberculosis drug-resistance: benchmarking existing databases and prediction algorithms
Tra-My Ngo,Yik Ying Teo +1 more
TL;DR: The good performance of the automated software for drug resistance prediction from TB WGS data shown in this study further substantiates the usefulness and promise of utilising genetic data to accurately profile TB drug resistance, thereby reducing misdiagnoses arising from error-prone culture-based drug susceptibility testing.
Journal ArticleDOI
Use of whole genome sequencing in surveillance of drug resistant tuberculosis.
TL;DR: There are considerable advantages to using next generation sequencing for TB drug resistance surveillance and the opportunity to replace phenotypic drug susceptibility testing with safer and more cost effective methods is presented.
Journal ArticleDOI
Linezolid interruption in patients with fluoroquinolone-resistant tuberculosis receiving a bedaquiline-based treatment regimen
TL;DR: Linezolid-related treatment interruption is common, is strongly associated with HIV co-infection, and system-specific toxicity occurs within predictable time frames, and these data inform the clinical management of patients with drug-resistant TB.
Journal Article
Surveillance of Anti-Tuberculosis Drug Resistance in the World: An Updated Analysis, 2007-2010/ Surveillance De la Resistance Aux Medicaments Antituberculeux Dans le Monde: Une Analyse Actualisee, 2007-2010/ Vigilancia De la Resistencia a Los Medicamentos Contra la Tuberculosis En Todo El Mundo: Analisis Actualizado, 2007-2010
Matteo Zignol,Wayne van Gemert,Dennis Falzon,Charalambos Sismanidis,Philippe Glaziou,Katherine Floyd,Mario C. Raviglione +6 more
TL;DR: The highest global rates of MDR-TB ever reported were documented in 2009 and 2010, and better surveillance or survey data are required, especially from Africa and India.
References
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Journal ArticleDOI
Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology.
Judith Kamerbeek,Leo M. Schouls,Arend H. J. Kolk,M van Agterveld,D. van Soolingen,Sjoukje Kuijper,Annelies Bunschoten,H Molhuizen,R J Shaw,M Goyal,J. D. A. Van Embden +10 more
TL;DR: A novel method based on strain-dependent hybridization patterns of in vitro-amplified DNA with multiple spacer oligonucleotides was found to differentiate M. bovis from M. tuberculosis, a distinction which is often difficult to make by traditional methods.
Journal ArticleDOI
Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology.
J. D. A. Van Embden,M. D. Cave,Jack T. Crawford,J. W. Dale,K. D. Eisenach,B Gicquel,Peter W. M. Hermans,Carlos Martin,R. A. Mcadam,Thomas M. Shinnick +9 more
TL;DR: In this article, the authors proposed a standardized technique which exploits variability in both the number and genomic position of IS6110 to generate strain-specific patterns for DNA fingerprinting of Mycobacterium tuberculosis.
Journal ArticleDOI
Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children
Gregory L. Kearns,Susan M. Abdel-Rahman,Sarah W. Alander,Douglas L. Blowey,J. Steven Leeder,Ralph E. Kauffman +5 more
TL;DR: This review examines the developmental changes that profoundly affect the responses of children to medications and related therapies in the very young.
Journal ArticleDOI
Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa
Neel R. Gandhi,Neel R. Gandhi,Anthony P. Moll,A. Willem Sturm,Robert Pawinski,Thiloshini Govender,Umesh G. Lalloo,Kimberly Zeller,Kimberly Zeller,Jason R. Andrews,Gerald Friedland +10 more
TL;DR: MDR tuberculosis is more prevalent than previously realised in a rural area in KwaZulu Natal, South Africa and has been transmitted to HIV co-infected patients and is associated with high mortality.
Journal ArticleDOI
Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis
Amalio Telenti,P Imboden,F Marchesi,Lukas Matter,K Schopfer,Thomas Bodmer,Douglas B. Lowrie,M.J Colston,Stewart T. Cole +8 more
TL;DR: Substitution of a limited number of highly conserved aminoacids encoded by the rpoB gene appears to be the molecular mechanism responsible for "single step" high-level resistance to rifampicin in M tuberculosis, a marker of multidrug-resistant tuberculosis.
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