Journal ArticleDOI
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
Keertan Dheda,Tawanda Gumbo,Gary Maartens,Kelly E. Dooley,Ruth McNerney,Megan Murray,Jennifer Furin,Edward A. Nardell,Leslie London,Erica Lessem,Grant Theron,Paul D. van Helden,Stefan Niemann,Matthias Merker,David W. Dowdy,Annelies Van Rie,Annelies Van Rie,Gilman Kit Hang Siu,Jotam G. Pasipanodya,Camilla Rodrigues,Taane G. Clark,F. A. Sirgel,Aliasgar Esmail,Hsien-Ho Lin,Sachin R Atre,H. Simon Schaaf,Kwok Chiu Chang,Christoph Lange,Payam Nahid,Zarir F Udwadia,C. Robert Horsburgh,Gavin J. Churchyard,Gavin J. Churchyard,Dick Menzies,Anneke C. Hesseling,Eric L. Nuermberger,Helen McIlleron,Kevin P. Fennelly,Eric Goemaere,Ernesto Jaramillo,Marcus Low,Carolina Morán Jara,Nesri Padayatchi,Robin M. Warren +43 more
Reads0
Chats0
TLDR
Several lines of evidence suggest that alternative mechanisms-including pharmacokinetic variability, induction of efflux pumps that transport the drug out of cells, and suboptimal drug penetration into tuberculosis lesions-are likely crucial to the pathogenesis of drug-resistant tuberculosis.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2017-04-01. It has received 461 citations till now. The article focuses on the topics: Bedaquiline & Delamanid.read more
Citations
More filters
Journal ArticleDOI
Inhibition of Transglutaminase 2 as a Potential Host-Directed Therapy Against Mycobacterium tuberculosis
Ivana Palucci,Giuseppe Maulucci,Flavio De Maio,Michela Sali,Alessandra Romagnoli,Linda Petrone,Gian Maria Fimia,Maurizio Sanguinetti,Delia Goletti,Marco De Spirito,Mauro Piacentini,Giovanni Delogu +11 more
TL;DR: It was shown that both cysteamine and cystamine restricted Mtb replication in infected macrophages when provided at equimolar concentrations and did not exert any antibacterial activity when administered directly on Mtb cultures.
Journal ArticleDOI
Using Bayesian spatial models to map and to identify geographical hotspots of multidrug-resistant tuberculosis in Portugal between 2000 and 2016
Olena Oliveira,Ana Isabel Ribeiro,Elias Teixeira Krainski,Teresa Rito,Raquel Duarte,Margarida Correia-Neves +5 more
TL;DR: This study analysed the spatial distribution of the MDR- and non-MDR-TB cases across municipalities in Continental Portugal between 2000 and 2016 to identify high- and low-risk areas and identified priority areas for intervention against TB.
Journal ArticleDOI
Prediction of treatment outcomes for multidrug-resistant tuberculosis by whole-genome sequencing.
TL;DR: WGS showed a promising feasibility in predicting treatment outcomes for MDR-TB patients within a clinically relevant time frame and independent risk factors associated with unfavorable treatment outcome were shown.
Journal ArticleDOI
Low Rate of Acquired Linezolid Resistance in Multidrug-Resistant Tuberculosis Treated With Bedaquiline-Linezolid Combination.
Jian Du,Jingtao Gao,Yanhong Yu,Qingfeng Li,Guanghong Bai,Wei Shu,Mengqiu Gao,Yuhong Liu,Lu Wang,Yufeng Wang,Zhongtan Xue,Fengmin Huo,Liang Li,Yu Pang +13 more
TL;DR: Wang et al. as discussed by the authors determined the prevalence of linezolid (LZD) resistance among multidrug-resistant tuberculosis (MDR-TB)-infected patients, and monitored for dynamic LZD susceptibility changes during anti-TB treatment.
Journal ArticleDOI
Diabetes is associated with genotypically drug-resistant tuberculosis
Carolien Ruesen,Lidya Chaidir,Cesar Ugarte-Gil,Cesar Ugarte-Gil,Cesar Ugarte-Gil,Jakko van Ingen,Julia A Critchley,Philip C. Hill,Rovina Ruslami,Prayudi Santoso,Martijn A. Huynen,Hazel M. Dockrell,David Moore,David Moore,Bachti Alisjahbana,Reinout van Crevel +15 more
TL;DR: WGS examined 1365 known drug resistance mutations in 896 Mycobacterium tuberculosis isolates from TB patients that were screened for diabetes using HbA1c testing as part of the TANDEM project, to determine M. tuberculosis lineage and drug resistance.
References
More filters
Journal ArticleDOI
Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology.
Judith Kamerbeek,Leo M. Schouls,Arend H. J. Kolk,M van Agterveld,D. van Soolingen,Sjoukje Kuijper,Annelies Bunschoten,H Molhuizen,R J Shaw,M Goyal,J. D. A. Van Embden +10 more
TL;DR: A novel method based on strain-dependent hybridization patterns of in vitro-amplified DNA with multiple spacer oligonucleotides was found to differentiate M. bovis from M. tuberculosis, a distinction which is often difficult to make by traditional methods.
Journal ArticleDOI
Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology.
J. D. A. Van Embden,M. D. Cave,Jack T. Crawford,J. W. Dale,K. D. Eisenach,B Gicquel,Peter W. M. Hermans,Carlos Martin,R. A. Mcadam,Thomas M. Shinnick +9 more
TL;DR: In this article, the authors proposed a standardized technique which exploits variability in both the number and genomic position of IS6110 to generate strain-specific patterns for DNA fingerprinting of Mycobacterium tuberculosis.
Journal ArticleDOI
Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children
Gregory L. Kearns,Susan M. Abdel-Rahman,Sarah W. Alander,Douglas L. Blowey,J. Steven Leeder,Ralph E. Kauffman +5 more
TL;DR: This review examines the developmental changes that profoundly affect the responses of children to medications and related therapies in the very young.
Journal ArticleDOI
Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa
Neel R. Gandhi,Neel R. Gandhi,Anthony P. Moll,A. Willem Sturm,Robert Pawinski,Thiloshini Govender,Umesh G. Lalloo,Kimberly Zeller,Kimberly Zeller,Jason R. Andrews,Gerald Friedland +10 more
TL;DR: MDR tuberculosis is more prevalent than previously realised in a rural area in KwaZulu Natal, South Africa and has been transmitted to HIV co-infected patients and is associated with high mortality.
Journal ArticleDOI
Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis
Amalio Telenti,P Imboden,F Marchesi,Lukas Matter,K Schopfer,Thomas Bodmer,Douglas B. Lowrie,M.J Colston,Stewart T. Cole +8 more
TL;DR: Substitution of a limited number of highly conserved aminoacids encoded by the rpoB gene appears to be the molecular mechanism responsible for "single step" high-level resistance to rifampicin in M tuberculosis, a marker of multidrug-resistant tuberculosis.
Related Papers (5)
A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis
Paolo Miotto,Belay Tessema,Elisa Tagliani,Leonid Chindelevitch,Angela M. Starks,Claudia Emerson,Debra Hanna,Peter S. Kim,Richard Liwski,Matteo Zignol,Christopher Gilpin,Stefan Niemann,Claudia M. Denkinger,Joy Fleming,Robin M. Warren,Derrick W. Crook,Derrick W. Crook,James E. Posey,Sebastien Gagneux,Sebastien Gagneux,Sven Hoffner,Sven Hoffner,Camilla Rodrigues,Iñaki Comas,David M. Engelthaler,Megan Murray,David Alland,Leen Rigouts,Christoph Lange,Keertan Dheda,Rumina Hasan,Uma Devi Ranganathan,Ruth McNerney,Matthew Ezewudo,Daniela Maria Cirillo,Marco Schito,Claudio U. Köser,Timothy C. Rodwell,Timothy C. Rodwell +38 more
Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study.
Timothy M Walker,Thomas Kohl,Shaheed V. Omar,Jessica Hedge,Carlos del Ojo Elias,Phelim Bradley,Zamin Iqbal,Silke Feuerriegel,Katherine E. Niehaus,Daniel J. Wilson,David A. Clifton,Georgia Kapatai,Camilla L. C. Ip,Rory Bowden,Francis Drobniewski,Francis Drobniewski,Caroline Allix-Béguec,Cyril Gaudin,Julian Parkhill,Roland Diel,Philip Supply,Philip Supply,Derrick W. Crook,E. Grace Smith,A. Sarah Walker,Nazir Ahmed Ismail,Stefan Niemann,Tim E. A. Peto +27 more
Delamanid for Multidrug-Resistant Pulmonary Tuberculosis
Maria Tarcela Gler,Vija Skripconoka,Epifanio Sanchez-Garavito,Heping Xiao,Jose L. Cabrera-Rivero,Dante E. Vargas-Vasquez,Mengqiu Gao,Mohamed A. Awad,Seung Kyu Park,Tae Sun Shim,Gee Young Suh,Manfred Danilovits,Hideo Ogata,Anu Kurve,Joon Chang,Katsuhiro Suzuki,Thelma E. Tupasi,Won-Jung Koh,Barbara J. Seaworth,Lawrence Geiter,Charles D. Wells +20 more
Rapid molecular detection of tuberculosis and rifampin resistance.
Catharina Boehme,Pamela Nabeta,Doris Hillemann,Mark P. Nicol,Shubhada Shenai,Fiorella Krapp,Jenny Allen,Rasim Tahirli,Robert Blakemore,Roxana Rustomjee,Ana Milovic,Martin Jones,Sean M. O'Brien,David H. Persing,Sabine Ruesch-Gerdes,Eduardo Gotuzzo,Camilla Rodrigues,David Alland,Mark D. Perkins +18 more