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Open AccessJournal ArticleDOI

The Excitatory Neuronal Network of the C2 Barrel Column in Mouse Primary Somatosensory Cortex

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TLDR
This data set provides the first functional description of the excitatory synaptic wiring diagram of a physiologically relevant and anatomically well-defined cortical column at single-cell resolution.
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This article is published in Neuron.The article was published on 2009-01-29 and is currently open access. It has received 871 citations till now. The article focuses on the topics: Cortical column & Biological neural network.

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Citations
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Canonical Microcircuits for Predictive Coding

TL;DR: This analysis discloses a remarkable correspondence between the microcircuitry of the cortical column and the connectivity implied by predictive coding and provides some intuitive insights into the functional asymmetries between feedforward and feedback connections and the characteristic frequencies over which they operate.
Journal ArticleDOI

Neurophysiological and Computational Principles of Cortical Rhythms in Cognition

TL;DR: A plethora of studies will be reviewed on the involvement of long-distance neuronal coherence in cognitive functions such as multisensory integration, working memory, and selective attention, and implications of abnormal neural synchronization are discussed as they relate to mental disorders like schizophrenia and autism.
Journal ArticleDOI

Reconstruction and Simulation of Neocortical Microcircuitry

Henry Markram, +92 more
- 08 Oct 2015 - 
TL;DR: A first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat is presented, finding a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms.
Book

Neuronal Dynamics: From Single Neurons to Networks and Models of Cognition

TL;DR: This textbook for advanced undergraduate and beginning graduate students provides a thorough and up-to-date introduction to the fields of computational and theoretical neuroscience.
Journal ArticleDOI

The neocortical circuit: themes and variations

TL;DR: Similarities in neocortical circuit organization across areas and species suggest a common strategy to process diverse types of information, including sensation from diverse modalities, motor control and higher cognitive processes.
References
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Journal ArticleDOI

Collective dynamics of small-world networks

TL;DR: Simple models of networks that can be tuned through this middle ground: regular networks ‘rewired’ to introduce increasing amounts of disorder are explored, finding that these systems can be highly clustered, like regular lattices, yet have small characteristic path lengths, like random graphs.
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Millisecond-timescale, genetically targeted optical control of neural activity.

TL;DR: In this paper, the authors adapted the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons.
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Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs

TL;DR: In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of post Synaptic action potentials and unitary excitatory postsynaptic potentials was found to induce changes in EPSPs.
Book

Spiking Neuron Models: Single Neurons, Populations, Plasticity

TL;DR: A comparison of single and two-dimensional neuron models for spiking neuron models and models of Synaptic Plasticity shows that the former are superior to the latter, while the latter are better suited to population models.
Journal ArticleDOI

Channelrhodopsin-2, a directly light-gated cation-selective membrane channel.

TL;DR: It is demonstrated by functional expression, both in oocytes of Xenopus laevis and mammalian cells, that ChR2 is a directly light-switched cation-selective ion channel, and may be used to depolarize small or large cells, simply by illumination.
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