The prevalence of MS in the United States: A population-based estimate using health claims data.
Mitchell T. Wallin,William J. Culpepper,Jonathan D. Campbell,Lorene M. Nelson,Annette Langer-Gould,Ruth Ann Marrie,Gary Cutter,Wendy E. Kaye,Laurie Wagner,Helen Tremlett,Stephen L. Buka,Piyameth Dilokthornsakul,Barbara Topol,Lie H. Chen,Nicholas G. LaRocca +14 more
TLDR
The estimated US national MS prevalence for 2010 is the highest reported to date and provides evidence that the north-south gradient persists and has the potential to be used for other chronic neurologic conditions.Abstract:
Objective To generate a national multiple sclerosis (MS) prevalence estimate for the United States by applying a validated algorithm to multiple administrative health claims (AHC) datasets. Methods A validated algorithm was applied to private, military, and public AHC datasets to identify adult cases of MS between 2008 and 2010. In each dataset, we determined the 3-year cumulative prevalence overall and stratified by age, sex, and census region. We applied insurance-specific and stratum-specific estimates to the 2010 US Census data and pooled the findings to calculate the 2010 prevalence of MS in the United States cumulated over 3 years. We also estimated the 2010 prevalence cumulated over 10 years using 2 models and extrapolated our estimate to 2017. Results The estimated 2010 prevalence of MS in the US adult population cumulated over 10 years was 309.2 per 100,000 (95% confidence interval [CI] 308.1–310.1), representing 727,344 cases. During the same time period, the MS prevalence was 450.1 per 100,000 (95% CI 448.1–451.6) for women and 159.7 (95% CI 158.7–160.6) for men (female:male ratio 2.8). The estimated 2010 prevalence of MS was highest in the 55- to 64-year age group. A US north-south decreasing prevalence gradient was identified. The estimated MS prevalence is also presented for 2017. Conclusion The estimated US national MS prevalence for 2010 is the highest reported to date and provides evidence that the north-south gradient persists. Our rigorous algorithm-based approach to estimating prevalence is efficient and has the potential to be used for other chronic neurologic conditions.read more
Citations
More filters
Journal ArticleDOI
Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition.
Clare Walton,Rachel King,Lindsay Rechtman,Wendy Kaye,Emmanuelle Leray,Ruth Ann Marrie,Neil Robertson,Nicholas La Rocca,Bernard M. J. Uitdehaag,Ingrid van der Mei,Mitchell T. Wallin,Anne Helme,Ceri Angood Napier,Nick Rijke,Peer Baneke +14 more
TL;DR: The global prevalence of MS has risen since 2013, but good surveillance data is not universal, and action is needed by multiple stakeholders to close knowledge gaps.
Journal ArticleDOI
Diagnosis and Treatment of Multiple Sclerosis: A Review.
TL;DR: A review of the evidence regarding diagnosis and treatment of MS can be found in this paper, where nine classes of disease-modifying therapies (DMTs), with varying mechanisms of action and routes of administration, are available for relapsing-remitting MS.
Journal ArticleDOI
Treatment of Multiple Sclerosis: A Review
TL;DR: The emergence of higher-efficacy drugs requiring less frequent administration have made these preferred options in terms of tolerability and adherence, and many experts now recommend use of these as first-line treatment for many patients with early disease, before permanent disability is evident.
Journal ArticleDOI
Outcomes and Risk Factors Associated With SARS-CoV-2 Infection in a North American Registry of Patients With Multiple Sclerosis.
Amber Salter,Robert J. Fox,Scott D. Newsome,June Halper,David K.B. Li,Pamela Kanellis,Kathleen Costello,Bruce F. Bebo,Kottil Rammohan,Gary Cutter,Anne H. Cross +10 more
TL;DR: In this paper, the authors examined outcomes and risk factors associated with COVID-19 clinical severity in a large, diverse cohort of North American patients with MS and concomitant SARS-CoV-2 infections.
Journal ArticleDOI
Environmental and genetic risk factors for MS: an integrated review.
Emmanuelle Waubant,Robyn M. Lucas,Ellen M. Mowry,Jennifer Graves,Tomas Olsson,Lars Alfredsson,Annette Langer-Gould +6 more
TL;DR: An integrated review of current evidence guides recommendations for clinical practice and highlights research gaps in multiple sclerosis.
References
More filters
Journal ArticleDOI
Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria
Chris H. Polman,Stephen C. Reingold,Brenda Banwell,Michel Clanet,Jeffrey A. Cohen,Massimo Filippi,Kazuo Fujihara,Eva Havrdova,Michael Hutchinson,Ludwig Kappos,Fred D. Lublin,Xavier Montalban,Paul L. O’Connor,Magnhild Sandberg-Wollheim,Alan J. Thompson,Emmanuelle Waubant,Brian G. Weinshenker,Jerry S. Wolinsky +17 more
TL;DR: These revisions simplify the McDonald Criteria, preserve their diagnostic sensitivity and specificity, address their applicability across populations, and may allow earlier diagnosis and more uniform and widespread use.
Journal ArticleDOI
Global, regional, and national burden of neurological disorders, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016
Valery L. Feigin,Amanuel Alemu Abajobir,Kalkidan Hassen Abate,Foad Abd-Allah,Abdishakur M. Abdulle,Semaw Ferede Abera,Gebre Yitayih Abyu,Muktar Beshir Ahmed,Amani Nidhal Aichour,Ibtihel Aichour,Miloud Taki Eddine Aichour,Rufus Akinyemi,Rufus Akinyemi,Samer Alabed,Rajaa Al-Raddadi,Nelson Alvis-Guzman,Azmeraw T. Amare,Hossein Ansari,Palwasha Anwari,Johan Ärnlöv,Hamid Asayesh,Solomon Weldegebreal Asgedom,Tesfay Mehari Atey,Leticia Avila-Burgos,Euripide Frinel,Euripide Frinel,G. Arthur Avokpaho,Mahmood Reza Azarpazhooh,Aleksandra Barac,Miguel A Barboza,Suzanne Barker-Collo,Till Bärnighausen,Till Bärnighausen,Neeraj Bedi,Ettore Beghi,Derrick A Bennett,Isabela M. Benseñor,Adugnaw Berhane,Balem Demtsu Betsu,Soumyadeep Bhaumik,Sait Mentes Birlik,Stan Biryukov,Dube Jara Boneya,Lemma Negesa Bulto Bulto,Hélène Carabin,Daniel C Casey,Carlos A Castañeda-Orjuela,Ferrán Catalá-López,Honglei Chen,Abdulaal A Chitheer,Rajiv Chowdhury,Hanne Christensen,Lalit Dandona,Lalit Dandona,Rakhi Dandona,Rakhi Dandona,Gabrielle de Veber,Samath D Dharmaratne,Huyen Phuc Do,Klara Dokova,E Ray Dorsey,Richard G. Ellenbogen,Sharareh Eskandarieh,Maryam S. Farvid,Seyed-Mohammad Fereshtehnejad,Florian Fischer,Kyle J Foreman,Kyle J Foreman,Johanna M. Geleijnse,Richard F. Gillum,Giorgia Giussani,Ellen M Goldberg,Philimon Gona,Alessandra C. Goulart,Harish Chander Gugnani,Rahul Gupta,Vladimir Hachinski,Rajeev Gupta,Randah R. Hamadeh,Mitiku Teshome Hambisa,Graeme J. Hankey,Habtamu Abera Hareri,Rasmus Havmoeller,Simon I. Hay,Simon I. Hay,Pouria Heydarpour,Peter J. Hotez,Mihajlo Jakovljevic,Mehdi Javanbakht,Panniyammakal Jeemon,Jost B. Jonas,Yogeshwar Kalkonde,Amit Kandel,André Karch,Amir Kasaeian,Anshul Kastor,Peter Njenga Keiyoro,Yousef Khader,Ibrahim A Khalil,Ejaz Ahmad Khan,Young-Ho Khang,Abdullah Tawfih,Abdullah T Khoja,Jagdish Khubchandani,Chanda Kulkarni,Daniel Kim,Yun Jin Kim,Mika Kivimäki,Mika Kivimäki,Yoshihiro Kokubo,Soewarta Kosen,Michael Kravchenko,Rita Krishnamurthi,Barthelemy Kuate Defo,G Anil Kumar,Rashmi Kumar,Hmwe H Kyu,Anders Larsson,Pablo M. Lavados,Yongmei Li,Xiaofeng Liang,Misgan Legesse Liben,Warren D. Lo,Warren D. Lo,Giancarlo Logroscino,Paulo A. Lotufo,Clement T. Loy,Mark T Mackay,Mark T Mackay,Hassan Magdy Abd El Razek,Mohammed Magdy Abd El Razek,Mohammed Magdy Abd El Razek,Azeem Majeed,Reza Malekzadeh,Treh Manhertz,Lorenzo G. Mantovani,João Massano,Mohsen Mazidi,Colm McAlinden,Suresh Mehata,Man Mohan Mehndiratta,Ziad A. Memish,Walter Mendoza,Mubarek Abera Mengistie,George A. Mensah,Atte Meretoja,Haftay Berhane Mezgebe,Ted R. Miller,Ted R. Miller,Shiva Raj Mishra,Norlinah Mohamed Ibrahim,Alireza Mohammadi,Kedir Endris Mohammed,Shafiu Mohammed,Shafiu Mohammed,Ali H. Mokdad,Maziar Moradi-Lakeh,Ilais Moreno Velásquez,Kamarul Imran Musa,Mohsen Naghavi,Josephine W. Ngunjiri,Cuong Tat Nguyen,Grant Nguyen,Quyen Nguyen,Trang Huyen Nguyen,Emma Nichols,Dina Nur Anggraini Ningrum,Dina Nur Anggraini Ningrum,Vuong Minh Nong,Bo Norrving,Jean Jacques Noubiap,Felix Akpojene Ogbo,Mayowa O. Owolabi,Jeyaraj D Pandian,P. Parmar,David M. Pereira,Max Petzold,Max Petzold,Michael R. Phillips,Michael R. Phillips,Michael A. Piradov,Richie Poulton,Farshad Pourmalek,Mostafa Qorbani,Anwar Rafay,Mahfuzar Rahman,Mohammad Hifz Ur Rahman,Rajesh Kumar Rai,Sasa Rajsic,Annemarei Ranta,Salman Rawaf,Andre M. N. Renzaho,Mohammad Sadegh Rezai,Gregory A. Roth,Gholamreza Roshandel,Gholamreza Roshandel,Enrico Rubagotti,Perminder S. Sachdev,Saeid Safiri,Ramesh Sahathevan,Mohammad Ali Sahraian,Abdallah M. Samy,Paula Santalucia,Itamar S. Santos,Benn Sartorius,Benn Sartorius,Maheswar Satpathy,Monika Sawhney,Mete Saylan,Sadaf G. Sepanlou,Masood Ali Shaikh,Raad Shakir,Morteza Shamsizadeh,Kevin N. Sheth,Mika Shigematsu,Mika Shigematsu,Haitham Shoman,Diego Augusto Santos Silva,Mari Smith,Eugene Sobngwi,Luciano A. Sposato,Jeffrey D. Stanaway,Dan J. Stein,Dan J. Stein,Timothy J. Steiner,Timothy J. Steiner,Lars Jacob Stovner,Rizwan Suliankatchi Abdulkader,Cassandra Szoeke,Rafael Tabarés-Seisdedos,David Tanne,David Tanne,Alice Theadom,Amanda G. Thrift,David L. Tirschwell,Roman Topor-Madry,Roman Topor-Madry,Bach Xuan Tran,Bach Xuan Tran,Thomas Truelsen,Kald Beshir Tuem,Kingsley N. Ukwaja,Olalekan A. Uthman,Yuri Y Varakin,Tommi Vasankari,Narayanaswamy Venketasubramanian,Vasiliy Victorovich Vlassov,Fiseha Wadilo,Tolassa Wakayo,Mitchell T. Wallin,Mitchell T. Wallin,Elisabete Weiderpass,Ronny Westerman,Tissa Wijeratne,Charles Shey Wiysonge,Charles Shey Wiysonge,Minyahil Alebachew Woldu,Minyahil Alebachew Woldu,Charles D.A. Wolfe,Charles D.A. Wolfe,Denis Xavier,Gelin Xu,Yuichiro Yano,Hassen Hamid Yimam,Naohiro Yonemoto,Chuanhua Yu,Zoubida Zaidi,Maysaa El Sayed Zaki,Joseph R. Zunt,Christopher J L Murray,Theo Vos +270 more
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors (GBD) study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions as discussed by the authors.
Projections of the Size and Composition of the U.S. Population: 2014 to 2060. Population Estimates and Projections. Current Population Reports. P25-1143.
TL;DR: The U.S. population is projected to grow more slowly in future decades than in the recent past, as these projections assume that fertility rates will continue to decline and that there will be a modest decline in the overall rate of net international migration as discussed by the authors.
Journal ArticleDOI
The Changing Demographic Pattern of Multiple Sclerosis Epidemiology
TL;DR: The literature search and meta-regression analyses indicated an almost universal increase in prevalence and incidence of MS over time; they challenge the well accepted theory of a latitudinal gradient of incidence in Europe and North America, while this gradient is still apparent for Australia and New Zealand; and suggest a general, although not ubiquitous, increase in incidence ofMS in females.
Related Papers (5)
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Alan J. Thompson,Brenda Banwell,Frederik Barkhof,Frederik Barkhof,William M. Carroll,Timothy Coetzee,Giancarlo Comi,Jorge Correale,Franz Fazekas,Massimo Filippi,Mark S. Freedman,Kazuo Fujihara,Steven L. Galetta,Hans-Peter Hartung,Ludwig Kappos,Fred D. Lublin,Ruth Ann Marrie,Aaron E. Miller,David Miller,Xavier Montalban,Xavier Montalban,Ellen M. Mowry,Per Soelberg Sørensen,Mar Tintoré,Anthony Traboulsee,Maria Trojano,Bernard M. J. Uitdehaag,Sandra Vukusic,Sandra Vukusic,Emmanuelle Waubant,Brian G. Weinshenker,Stephen C. Reingold,Jeffrey A. Cohen +32 more
Rating neurologic impairment in multiple sclerosis An expanded disability status scale (EDSS)
Defining the clinical course of multiple sclerosis: The 2013 revisions
Fred D. Lublin,Stephen C. Reingold,Jeffrey A. Cohen,Gary Cutter,Per Soelberg Sørensen,Alan J. Thompson,Jerry S. Wolinsky,Laura J. Balcer,Brenda Banwell,Frederik Barkhof,Bruce F. Bebo,Peter A. Calabresi,Michel Clanet,Giancarlo Comi,Robert J. Fox,Mark S. Freedman,Andrew D. Goodman,Matilde Inglese,Ludwig Kappos,Bernd C. Kieseier,John A. Lincoln,Catherine Lubetzki,Aaron E. Miller,Xavier Montalban,Paul O'Connor,John Petkau,Carlo Pozzilli,Richard A. Rudick,Maria Pia Sormani,Olaf Stüve,Emmanuelle Waubant,Chris H. Polman +31 more
Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria
Chris H. Polman,Stephen C. Reingold,Brenda Banwell,Michel Clanet,Jeffrey A. Cohen,Massimo Filippi,Kazuo Fujihara,Eva Havrdova,Michael Hutchinson,Ludwig Kappos,Fred D. Lublin,Xavier Montalban,Paul L. O’Connor,Magnhild Sandberg-Wollheim,Alan J. Thompson,Emmanuelle Waubant,Brian G. Weinshenker,Jerry S. Wolinsky +17 more