The type I interferon response in COVID-19: implications for treatment.
Jeong Seok Lee,Eui-Cheol Shin +1 more
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TLDR
Lee et al. as discussed by the authors showed that a robust type I interferon response could exacerbate hyperinflammation in the progression to severe COVID-19 through diverse mechanisms, and further understanding of the roles of type I Interferon at different stages of infection and in patients with mild versus severe CoV-19 will provide insights for the therapeutic use of interferron administration or JAK inhibitors.Abstract:
Despite early reports to the contrary, there is increasing evidence that patients with severe COVID-19 have a robust type I interferon response, which contrasts with the delayed, possibly suppressed, interferon response seen early in infection. A robust type I interferon response could exacerbate hyperinflammation in the progression to severe COVID-19 through diverse mechanisms. Further understanding of the roles of type I interferon at different stages of infection and in patients with mild versus severe COVID-19 will provide insights for the therapeutic use of interferon administration or JAK inhibitors in patients with COVID-19. In this Comment, Jeong Seok Lee and Eui-Cheol Shin discuss contradictory results regarding the downregulation or upregulation of type I interferon responses in patients with COVID-19 and the implications for therapies that target this pathway.read more
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COVID-19 and the human innate immune system.
TL;DR: In this article, a conceptual framework for the interaction of the human innate immune system with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was provided to link the clinical observations with experimental findings that have been made during the first year of the pandemic.
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Immunological mechanisms of vaccine-induced protection against COVID-19 in humans.
TL;DR: Most COVID-19 vaccines have been designed to elicit immune responses, ideally neutralizing antibodies (NAbs), against the SARS-CoV-2 spike protein this article.
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The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
Jeremy Di Domizio,Muhammet F. Gulen,Fanny Saidoune,Vivek V. Thacker,Ahmad Yatim,Kunal Sharma,Théo Nass,Emmanuella Guenova,Martin Schaller,Curdin Conrad,Christine Goepfert,Laurence de Leval,Christophe von Garnier,Sabina Berezowska,Anaëlle Dubois,Michel Gilliet,Andrea Ablasser +16 more
TL;DR: In this article , the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, which controls immunity to cytosolic DNA, is a critical driver of aberrant type I IFN responses in COVID-19.
Journal ArticleDOI
The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
Jeremy Di Domizio,Muhammet F. Gulen,Fanny Saidoune,Vivek V. Thacker,Ahmad Yatim,Kunal Sharma,Théo Nass,Emmanuella Guenova,Martin Schaller,Curdin Conrad,Christine Goepfert,Laurence de Leval,Christophe von Garnier,Sabina Berezowska,Anaëlle Dubois,Michel Gilliet,Andrea Ablasser +16 more
TL;DR: In this paper , the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, which controls immunity to cytosolic DNA, is a critical driver of aberrant type I IFN responses in COVID-19.
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SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells.
Jae Hyung Jung,Min-Seok Rha,Min-Seok Rha,Moa Sa,Hee Kyoung Choi,Ji Hoon Jeon,Hyeri Seok,Dae Won Park,Su-Hyung Park,Hye Won Jeong,Won Suk Choi,Eui-Cheol Shin +11 more
TL;DR: In this article, SARS-CoV-2-specific CD4+ and CD8+ T cell responses were evaluated in COVID-19 convalescent patients up to 317 days post-symptom onset (DPSO).
References
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Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.
Jérôme Hadjadj,Nader Yatim,Laura Barnabei,Aurélien Corneau,Jeremy Boussier,Nikaïa Smith,Hélène Péré,Bruno Charbit,Vincent Bondet,Camille Chenevier-Gobeaux,Paul Breillat,Nicolas Carlier,Rémy Gauzit,Caroline Morbieu,Frédéric Pène,Nathalie Marin,Nicolas Roche,Tali Anne Szwebel,Sarah H. Merkling,Jean-Marc Treluyer,David Veyer,Luc Mouthon,Catherine Blanc,Pierre-Louis Tharaux,Flore Rozenberg,Alain Fischer,Alain Fischer,Alain Fischer,Darragh Duffy,Frédéric Rieux-Laucat,Solen Kernéis,Solen Kernéis,Benjamin Terrier +32 more
TL;DR: The results of this trio of studies suggest that the location, timing, and duration of IFN exposure are critical parameters underlying the success or failure of therapeutics for viral respiratory infections.
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Longitudinal analyses reveal immunological misfiring in severe COVID-19.
Carolina Lucas,Patrick Wong,Jon Klein,Tiago B. R. Castro,Julio Silva,Maria E. Sundaram,Mallory K. Ellingson,Tianyang Mao,Ji Eun Oh,Benjamin Israelow,Takehiro Takahashi,Maria Tokuyama,Peiwen Lu,Arvind Venkataraman,Annsea Park,Subhasis Mohanty,Haowei Wang,Anne L. Wyllie,Chantal B.F. Vogels,Rebecca Earnest,Sarah Lapidus,Isabel M. Ott,Adam J. Moore,M. Catherine Muenker,John Fournier,Melissa Campbell,Camila D. Odio,Arnau Casanovas-Massana,Roy S. Herbst,Albert C. Shaw,Ruslan Medzhitov,Ruslan Medzhitov,Wade L. Schulz,Nathan D. Grubaugh,Charles S. Dela Cruz,Shelli F. Farhadian,Albert I. Ko,Saad B. Omer,Akiko Iwasaki,Akiko Iwasaki +39 more
TL;DR: A longitudinal analysis of immune responses in patients with moderate or severe COVID-19 identifies a maladapted immune response profile linked to severe disease, as well as early immune signatures that correlate with divergent disease trajectories.
Journal ArticleDOI
Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice
Rudragouda Channappanavar,Anthony R. Fehr,Rahul Vijay,Matthias Mack,Jincun Zhao,David K. Meyerholz,Stanley Perlman +6 more
TL;DR: Using mice infected with SARS-CoV, it is demonstrated that robust virus replication accompanied by delayed type I interferon (IFN-I) signaling orchestrates inflammatory responses and lung immunopathology with diminished survival and is identified as a potential therapeutic targets in patients infected with pathogenic coronavirus and perhaps other respiratory viruses.
Journal ArticleDOI
A single-cell atlas of the peripheral immune response in patients with severe COVID-19.
Aaron J. Wilk,Arjun Rustagi,Nancy Q. Zhao,Jonasel Roque,Giovanny J Martínez-Colón,Julia L. McKechnie,Geoffrey T. Ivison,Thanmayi Ranganath,Rosemary Vergara,Taylor Mi Hollis,Laura J. Simpson,Philip M. Grant,Aruna Subramanian,Albert J. Rogers,Catherine A. Blish +14 more
TL;DR: Single-cell transcriptomic analysis identifies changes in peripheral immune cells in seven hospitalized patients with COVID-19, including HLA class II downregulation, a heterogeneous interferon-stimulated gene signature and low pro-inflammatory cytokine gene expression in monocytes and lymphocytes.
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