Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
More filters
Journal ArticleDOI
How physico-chemical characteristics of nanoparticles cause their toxicity: complex and unresolved interrelations
TL;DR: Different critical physico-chemical characteristics separately with toxicity observed in both in vitro and in vivo models are linked.
Journal ArticleDOI
Green synthesis and characterization of silver nanoparticles from Moringa oleifera flower and assessment of antimicrobial and sensing properties.
TL;DR: The obtained antimicrobial and optical properties of silver nanoparticles from Moringa oleifera flower extract, suggested the use of obtained AgNPs in water purification.
Journal ArticleDOI
Respiratory epithelial cytotoxicity and membrane damage (holes) caused by amine-modified nanoparticles
Pakatip Ruenraroengsak,Pavel Novák,Deborah Berhanu,Andrew J. Thorley,Eugenia Valsami-Jones,Julia Gorelik,Yuri E. Korchev,Teresa D. Tetley +7 more
TL;DR: The susceptibility and membrane damage to respiratory epithelium following inhalation of NPs will depend on both surface chemistry (e.g., cationic) and nano-size.
Journal ArticleDOI
Life cycle assessment at nanoscale: review and recommendations
TL;DR: Evaluating how the nano-specific environmental assessments are being done within the existing framework of life cycle inventory and impact assessment and whether these frameworks are valid and/or whether they can be modified for nano-evaluations indicates that nano-LCA studies need not omit the assessment of nanomaterials’ human health and environmental impact due to incomplete data.
Journal ArticleDOI
Gold nanorods as molecular contrast agents in photoacoustic imaging: the promises and the caveats.
TL;DR: An short overview of the current status of the use of AuNR in molecular imaging using photoacoustics is provided and the state of the art in various chemical, physical and biochemical phenomena that have implications for the future photoacoustic applications of these particles are examined.
References
More filters
Journal ArticleDOI
Toxic Potential of Materials at the Nanolevel
TL;DR: The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable.
Journal ArticleDOI
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
TL;DR: Results of older bio-kinetic studies with NSPs and newer epidemiologic and toxicologic studies with airborne ultrafine particles can be viewed as the basis for the expanding field of nanotoxicology, which can be defined as safety evaluation of engineered nanostructures and nanodevices.
Journal ArticleDOI
Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications
Sophie Laurent,Delphine Forge,Marc Port,Alain Roch,Caroline Robic,Luce Vander Elst,Robert N. Muller +6 more
TL;DR: Practical Interests of Magnetic NuclearRelaxation for the Characterization of Superparamagnetic Colloid, and Use of Nanoparticles as Contrast Agents forMRI20825.
Journal ArticleDOI
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
Journal ArticleDOI
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
TL;DR: This work has shown that addition of PEG and PEG-containing copolymers to the surface of nanoparticles results in an increase in the blood circulation half-life of the particles by several orders of magnitude, and creates a hydrophilic protective layer around the nanoparticles that is able to repel the absorption of opsonin proteins via steric repulsion forces.