Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
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Application of Förster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines.
TL;DR: Forster Resonance Energy Transfer (FRET) is a powerful tool to reveal changes and interaction of nanoparticles after delivery, which will be very useful to guide future developments of nanomedicine as discussed by the authors.
Journal ArticleDOI
Nanosurface chemistry and dose govern the bioaccumulation and toxicity of carbon nanotubes, metal nanomaterials and quantum dots in vivo
TL;DR: The recent advances in nanotoxicological chemistry are summarized through the dissection of pivotal factors (primarily focusing on dose and nanosurface chemistry) in determining nanomaterial-induced biological/toxic responses with particular emphasis on the nanomMaterial bioaccumulation at intact animal level.
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Isothermal titration calorimetry as a complementary method for investigating nanoparticle–protein interactions
TL;DR: This minireview concludes that nanomaterials formed of a hydrophilic material without strongly charged surface and steric stabilization experience the weakest interactions with proteins and are most promising for allowing an engineering of the protein corona.
Journal ArticleDOI
Stresses exerted by ZnO, CeO2 and anatase TiO2 nanoparticles on the Nitrosomonas europaea
TL;DR: Experimental results suggest that ZnO particles exert the stress on cells by its dissolution and releasing of Zn(2+) ions, and the TEM and AUC result suggest that cells become heavier in presence of CeO(2) and TiO( 2) particles.
Journal ArticleDOI
Multifunctional gold-based nanocomposites for theranostics.
TL;DR: This review is focused on multifunctional gold-based theranostic nanocomposites, which can be fabricated by three main routes: to create composite (or hybrid) nanoparticles, whose components enable diagnostic and therapeutic functions, and a combination of the first two.
References
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