Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
More filters
Journal ArticleDOI
Nanostructured metal oxide-based biosensors
TL;DR: Nanostructured metal oxides (NMOs) have recently become important as materials that provide an effective surface for biomolecule immobilization with desired orientation, better conformation and high biological activity resulting in enhanced sensing characteristics as mentioned in this paper.
Journal ArticleDOI
PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics
Jillian L. Perry,Kevin G. Reuter,Marc P. Kai,Kevin P. Herlihy,Kevin P. Herlihy,Stephen W. Jones,J. Chris Luft,Mary E. Napier,Mary E. Napier,James E. Bear,Joseph M. DeSimone,Joseph M. DeSimone +11 more
TL;DR: Overall, the methodology provides a rapid screening technique to predict particle behavior in vivo and the results deliver further insight to what PEG density is necessary to facilitate long-circulation.
Journal ArticleDOI
Physicochemical properties of nanomaterials: implication in associated toxic manifestations
Manzoor Ahmad Gatoo,Sufia Naseem,Mir Yasir Arfat,Ayaz Mahmood Dar,Khusro Qasim,Swaleha Zubair +5 more
TL;DR: Physicochemical characteristics of nanoparticles and engineered nanomaterials including size, shape, chemical composition, physiochemical stability, crystal structure, surface area, surface energy, and surface roughness generally influence the toxic manifestations of these nanom materials.
Journal ArticleDOI
Size matters: gold nanoparticles in targeted cancer drug delivery.
TL;DR: This review will highlight some recent advances in the use of Au nanoparticles for systemic drug delivery to these malignancies and provide insights into their rational design, synthesis, physiological properties and clinical/preclinical applications, as well as strategies and challenges toward the clinical implementation of these constructs moving forward.
Journal ArticleDOI
Assessing the in vitro and in vivo toxicity of superparamagnetic iron oxide nanoparticles.
Morteza Mahmoudi,Morteza Mahmoudi,Morteza Mahmoudi,Heinrich Hofmann,Barbara Rothen-Rutishauser,Barbara Rothen-Rutishauser,Alke Petri-Fink +6 more
TL;DR: The following definitions for a nanoparticle (NP) and a nano-object will be used.
References
More filters
Journal ArticleDOI
Toxic Potential of Materials at the Nanolevel
TL;DR: The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable.
Journal ArticleDOI
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
TL;DR: Results of older bio-kinetic studies with NSPs and newer epidemiologic and toxicologic studies with airborne ultrafine particles can be viewed as the basis for the expanding field of nanotoxicology, which can be defined as safety evaluation of engineered nanostructures and nanodevices.
Journal ArticleDOI
Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications
Sophie Laurent,Delphine Forge,Marc Port,Alain Roch,Caroline Robic,Luce Vander Elst,Robert N. Muller +6 more
TL;DR: Practical Interests of Magnetic NuclearRelaxation for the Characterization of Superparamagnetic Colloid, and Use of Nanoparticles as Contrast Agents forMRI20825.
Journal ArticleDOI
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
Journal ArticleDOI
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
TL;DR: This work has shown that addition of PEG and PEG-containing copolymers to the surface of nanoparticles results in an increase in the blood circulation half-life of the particles by several orders of magnitude, and creates a hydrophilic protective layer around the nanoparticles that is able to repel the absorption of opsonin proteins via steric repulsion forces.