Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
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Overview of current toxicological knowledge of engineered nanoparticles.
TL;DR: If certain nanoparticles induce adverse effects in vitro or in animal models, then occupational health surveillance and exposure control may be prudent steps in the protection of worker health.
Journal ArticleDOI
The adsorption of biomolecules to multi-walled carbon nanotubes is influenced by both pulmonary surfactant lipids and surface chemistry
Michael Gasser,Barbara Rothen-Rutishauser,Harald F. Krug,Peter Gehr,Mathias Nelle,Bing Yan,Bing Yan,Peter Wick +7 more
TL;DR: It was shown that surfactant lipids bind unspecifically to different functionalized MWCNTs, in contrast to the blood plasma proteins which showed characteristic binding patterns.
Journal ArticleDOI
Probe-inspired nano-prodrug with dual-color fluorogenic property reveals spatiotemporal drug release in living cells.
Xiangdong Xue,Shubin Jin,Chunqiu Zhang,Keni Yang,Shuaidong Huo,Fei Chen,Guozhang Zou,Xing-Jie Liang +7 more
TL;DR: By examining the spatiotemporal pattern of TPE and DOX, this work was able to precisely disclose the drug-releasing site, the releasing time, the destinations of the carriers, and the executing site of the drugs at subcellular level.
Journal ArticleDOI
Crossing biological barriers with nanogels to improve drug delivery performance
Julio César Cuggino,Ernesto Rafael Osorio Blanco,Luis Marcelino Gugliotta,Cecilia Ines Alvarez Igarzabal,Marcelo Calderón,Marcelo Calderón +5 more
TL;DR: The present review summarizes the most significant developments of NGs as smart carriers, with focus on smart modalities to cross biological barriers such as cellular membrane, tumor stroma, mucose, skin, and blood brain barrier.
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Polyamidoamine dendrimer nanoparticle cytotoxicity, oxidative stress, caspase activation and inflammatory response: experimental observation and numerical simulation
TL;DR: The intracellular mechanism of PAMAM dendrimer cytotoxicity in human keratinocytes is explored, and it is suggested that responses can be quantified in terms of rate constants rather than effective concentrations.
References
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