Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
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Central nervous system toxicity of metallic nanoparticles.
TL;DR: The dual effect of NMs on the CNS and the mechanisms involved are discussed, and the limitations of the current research are discussed.
Journal ArticleDOI
Co-delivery of a hydrophobic small molecule and a hydrophilic peptide by porous silicon nanoparticles
Dongfei Liu,Luis M. Bimbo,Ermei Mäkilä,Francesca Villanova,Francesca Villanova,Martti Kaasalainen,Bárbara Herranz-Blanco,Carla Caramella,Vesa-Pekka Lehto,Jarno Salonen,Karl-Heinz Herzig,Jouni Hirvonen,Hélder A. Santos +12 more
TL;DR: These results are the first demonstration of the promising potential of PSi NPs for simultaneous multi-drug delivery of both hydrophobic and hydrophilic compounds.
Journal ArticleDOI
Cellular Targets and Mechanisms in the Cytotoxic Action of Non-biodegradable Engineered Nanoparticles
TL;DR: This review introduces problems of NPs in conventional cytotoxicity testing (changes of particle parameters in biological fluids, cellular dose, cell line and assay selection), and generation of reactive oxygen and nitrogen species by NPs and of metal ions due to dissolution of the NPs is discussed as a cause for cytot toxicity.
Journal ArticleDOI
Advances in silica based nanoparticles for targeted cancer therapy.
Yannan Yang,Chengzhong Yu +1 more
TL;DR: A comprehensive overview of the use of mesoporous silica nanoparticle in both passive, as well as active targeting in the field of oncology, and the advantages of this particle were further discussed.
Journal ArticleDOI
Organic Switches for Surfaces and Devices
Albert C. Fahrenbach,Scott C. Warren,Jared T. Incorvati,Alyssa-Jennifer Avestro,Jonathan C. Barnes,J. Fraser Stoddart,Bartosz A. Grzybowski +6 more
TL;DR: Light is shed on recent advances made in the laboratories towards integrated systems using all-organic switches on a variety of substrates, while emphasizing the considerable promise and formidable challenges these advanced composite materials pose when it comes to conferring function on them.
References
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Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
TL;DR: This work has shown that addition of PEG and PEG-containing copolymers to the surface of nanoparticles results in an increase in the blood circulation half-life of the particles by several orders of magnitude, and creates a hydrophilic protective layer around the nanoparticles that is able to repel the absorption of opsonin proteins via steric repulsion forces.