Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
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Journal ArticleDOI
Corona Composition Can Affect the Mechanisms Cells Use to Internalize Nanoparticles.
TL;DR: The results confirmed that the corona composition can affect the mechanisms of nanoparticle uptake by cells, and suggested that coronas of different composition can be recognized differently by cell receptors, and this leads to internalization via different mechanisms.
Journal ArticleDOI
A Review of the Properties and Processes Determining the Fate of Engineered Nanomaterials in the Aquatic Environment
Willie J.G.M. Peijnenburg,Mohammed Baalousha,Jingwen Chen,Q. Chaudry,F. von der Kammer,Thomas A. J. Kuhlbusch,Carmen Nickel,Joris T.K. Quik,M. Renkerg,Albert A. Koelmans +9 more
TL;DR: In this article, the authors provide background reading to the NM and media specific properties and processes that affect the fate and behavior of engineered nanomaterials in aquatic environments, focusing on specific properties of NMs that modulate the interactions in the aquatic environment.
Journal ArticleDOI
Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery
Liwang Shi,Jinqiu Zhang,Man Zhao,Shukun Tang,Xu Cheng,Wenyuan Zhang,Wenhua Li,Xiaoying Liu,Haisheng Peng,Qun Wang +9 more
TL;DR: In this article, the authors discuss the PEGylation methods of nanoparticles and related techniques that have been used to detect the coverage density and thickness on the surface of the nanoparticles in recent years.
Journal ArticleDOI
Interlaboratory comparison of size measurements on nanoparticles using nanoparticle tracking analysis (NTA)
Patrick Hole,Katherine Sillence,Claire Hannell,Ciaran Manus Maguire,Matthias Roesslein,Guillaume Suarez,Sonja Capracotta,Zuzana Magdolenova,Limor Horev-Azaria,Agnieszka Dybowska,Laura Cooke,Andrea Haase,Servane Contal,Stein Manø,Antje Vennemann,Jeans-Jacques Sauvain,Kieran Crosbie Staunton,Sergio Anguissola,Andreas Luch,Maria Dusinska,Rafi Korenstein,Arno C. Gutleb,Martin Wiemann,Adriele Prina-Mello,Michael Riediker,Peter Wick +25 more
TL;DR: This study looks at the reproducibility using a relatively new, but rapidly adopted, technique, Nanoparticle Tracking Analysis (NTA) on a range of particle sizes and materials in several different media and how this leads to highly reproducible results amongst participants.
Journal ArticleDOI
Surface-structure-regulated penetration of nanoparticles across a cell membrane
TL;DR: In this article, the authors performed dissipative particle dynamics simulations to analyze the evolution of free energy as the ligand-coated nanoparticles pierce through a lipid bilayer and found that the translocation of the striated NP is facilitated by the constraint of its rotational degree of freedom by the anisotropic ligand pattern, which prevented the free energy of the system from sinking to a deeper valley as the NP passes through the hydrophobic core of the bilayer.
References
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