Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
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Adsorption of a Protein Monolayer via Hydrophobic Interactions Prevents Nanoparticle Aggregation under Harsh Environmental Conditions
TL;DR: The formation of the BSA corona presented here provides a low-cost bio-compatible strategy for nanoparticle stabilization and transport in highly ionic environments.
Journal ArticleDOI
Stem Cell Aligned Growth Induced by CeO2 Nanoparticles in PLGA Scaffolds with Improved Bioactivity for Regenerative Medicine
Corrado Mandoli,Francesca Pagliari,Stefania Pagliari,Giancarlo Forte,Paolo Di Nardo,Silvia Licoccia,Enrico Traversa,Enrico Traversa +7 more
TL;DR: In this paper, a hybrid 2D polymeric-ceramic biosupports are fabricated by mixing a nanostructured CeO2 powder with 85:15 poly(D,L-lactic-co-glycolic acid) (PLGA)/dichloromethane solutions at specific concentrations, followed by solvent casting onto pre-patterned molds.
Journal ArticleDOI
Mycosynthesis of silver and gold nanoparticles: Optimization, characterization and antimicrobial activity against human pathogens
M. D. Balakumaran,R. Ramachandran,P. Balashanmugam,D.J. Mukeshkumar,Pudupalayam Thangavelu Kalaichelvan +4 more
TL;DR: The obtained results clearly reveal that these antimicrobial nanoparticles could be explored as promising candidates for a variety of biomedical and pharmaceutical applications.
Journal ArticleDOI
Ecotoxicological assessment of silica and polystyrene nanoparticles assessed by a multitrophic test battery
TL;DR: The cytotoxicity studies were found not to be a reliable ecotoxicity test model as agglomeration and sedimentation of the nanoparticles was observed at these concentrations, but the effects observed were dependent in some cases on the NP size, a higher effect being observed for the larger NPs.
Journal ArticleDOI
Imparting Functionality to MOF Nanoparticles by External Surface Selective Covalent Attachment of Polymers
Andreas Zimpel,Tobias Preiß,Ruth Röder,Hanna Engelke,Michael Ingrisch,Michael Peller,Joachim O. Rädler,Ernst Wagner,Thomas Bein,Ulrich Lächelt,Stefan Wuttke +10 more
TL;DR: This work proves covalent nanoparticles-polymer bond formation by liquid NMR after dissolution of the functionalized MOF under mild conditions and estimates the amount of covalently attached polymer by UV–vis spectroscopy.
References
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