Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
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Improved EIS Performance of an Electrochemical Cytosensor Using Three-Dimensional Architecture Au@BSA as Sensing Layer
TL;DR: This proposed cytosensing strategy revealed high specificity to CEA-positive cells, acceptable intra-assay precision, excellent fabrication reproducibility with the RSD of 3.5%, and good stability owing to the outside BSA biocompatible layer, developing a promising technique for early monitoring of tumor cells at a lower level.
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Subcellular Performance of Nanoparticles in Cancer Therapy
TL;DR: The intracellular pathways of nanoparticles are summarized, highlighting the principles and state of their destructive effects in the subcellular structures as well as the current limitations of conventional therapeutic approaches to address the contemporary challenges in their clinical applicability.
Journal ArticleDOI
Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation.
TL;DR: This review covers the advances in vaccine nanotechnology with a perspective on the advantages of virus mimicry towards immune potentiation with an overview to the different types of nanomaterials utilized for nanoparticle vaccine development, including functionalization strategies that bestow nanoparticles with virus-like features.
Journal ArticleDOI
Less is more: long-term in vitro exposure to low levels of silver nanoparticles provides new insights for nanomaterial evaluation.
TL;DR: It is demonstrated that through implementation of a chronic dosimetry paradigm, which more closely resembles realistic NM exposure scenarios, it is possible to illuminate long-term cellular consequences, which greatly differ from previously obtained acute assessments.
Journal ArticleDOI
Nanoparticles Inhibit DNA Replication by Binding to DNA: Modeling and Experimental Validation
TL;DR: This work determined the interaction energy between 12 types of NPs and DNA based on the Derjaguin-Landau-Verwey-Overbeek (DLVO) model and predicted the affinity and experimentally determined the binding affinity of those NPs for DNA.
References
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