Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
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Predicting the environmental impact of nanosilver
TL;DR: The AgNP production, environmental release and fate, predicted environmental concentrations in surface water, sediment, and sludge-activated soil, as well as reported toxicity and proposed toxic mechanisms are discussed, focusing primarily on fish.
Journal ArticleDOI
Toxicological Profiling of Metal Oxide Nanoparticles in Liver Context Reveals Pyroptosis in Kupffer Cells and Macrophages versus Apoptosis in Hepatocytes.
Vahid Mirshafiee,Bingbing Sun,Bingbing Sun,Chong Hyun Chang,Yu-Pei Liao,Wen Jiang,Jinhong Jiang,Xiangsheng Liu,Xiang Wang,Tian Xia,Andre E. Nel +10 more
TL;DR: Important mechanistic considerations that can be used for safety evaluation of metal oxides, including commercial products that are developed from these materials are demonstrated.
Journal ArticleDOI
Significance of surface charge and shell material of superparamagnetic iron oxide nanoparticle (SPION) based core/shell nanoparticles on the composition of the protein corona
Usawadee Sakulkhu,Morteza Mahmoudi,Morteza Mahmoudi,Lionel Maurizi,Géraldine Coullerez,Margarethe Hofmann-Amtenbrink,Marcel P. de Vries,M. M. Motazacker,Farhad Rezaee,Heinrich Hofmann +9 more
TL;DR: The surface charge has a great impact on protein adsorption, especially on PVA and silica where proteins preferred binding to the neutral and positively charged surfaces, as well as preferential binding on TiO2 and gold coated SPION, even negatively charged.
Journal ArticleDOI
Magnetic iron oxide nanoparticles: Recent trends in design and synthesis of magnetoresponsive nanosystems.
TL;DR: This review focuses on the structural and magnetic characterization of the cores, the synthesis of single- and multicore iron oxide NPs, especially the design of the latter, as well as their protection, stabilization and functionalization by desired coating in order to protect against the corrosion of core, to prevent non-specific protein adsorption and particle aggregation in biological media, and to provide binding sites for targeting and therapeutic agents.
Journal ArticleDOI
Biosensing Using Magnetic Particle Detection Techniques
TL;DR: This review focuses on magnetic sensing applications that utilize several types of magnetic detection techniques: spintronic sensors, nuclear magnetic resonance sensors, superconducting quantum interference devices (SQUIDs), sensors based on the atomic magnetometer (AM), and others.
References
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Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
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