Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
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The Role of Surface Functionality on Acute Cytotoxicity, ROS Generation and DNA Damage by Cationic Gold Nanoparticles
Apiwat Chompoosor,Krishnendu Saha,Partha S. Ghosh,Dylan J. Macarthy,Oscar R. Miranda,Zheng-Jiang Zhu,Kathleen F. Arcaro,Vincent M. Rotello +7 more
TL;DR: To date, issues such as ligand hydrophobicity have not been systematically explored and several studies on the short-term cytotoxicity of AuNPs and quantum dots have focused on size, shape, and charge.
Journal ArticleDOI
Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity.
TL;DR: The most recent developments in NP-based protein coronas through the modification of NP surface properties are reviewed and the associated immune responses are discussed.
Journal ArticleDOI
The controversial antibacterial activity of graphene-based materials
Hanaa M. Hegab,Ahmed ElMekawy,Ahmed ElMekawy,Linda Zou,Linda Zou,Dennis Mulcahy,Christopher P. Saint,Milena Ginic-Markovic +7 more
TL;DR: Graphene (Gr)-based materials are a promising nanomaterial for the development of antibacterial surfaces owing to their biocidal activity as mentioned in this paper, however, the effect of the physicochemical features of these materials on their antibacterial activity has yet to be clarified.
Journal ArticleDOI
Nanoparticle Size and Coating Chemistry Control Foliar Uptake Pathways, Translocation, and Leaf-to-Rhizosphere Transport in Wheat
Astrid Avellan,Jie Yun,Yilin Zhang,Eleanor Spielman-Sun,Jason M. Unrine,Juergen Thieme,Jieran Li,Enzo Lombi,Garret D. Bland,Gregory V. Lowry +9 more
TL;DR: This study used a combination of Au quantification and spatial analysis to investigate how size and coating chemistry of gold nanoparticles influence their interactions with plant leaves, uptake, translocation through the mesophyll to the vasculature, and transport to the rest of the plant.
Journal ArticleDOI
Personalized protein coronas: a “key” factor at the nanobiointerface
Mohammad Javad Hajipour,Sophie Laurent,Afsaneh Aghaie,Farhad Rezaee,Farhad Rezaee,Morteza Mahmoudi,Morteza Mahmoudi +6 more
TL;DR: This study incubated two different hydrophobic/hydrophilic types of NPs with plasma from human subjects with different diseases and medical conditions and demonstrated that the type of disease has a crucial role in the protein composition of the NP corona.
References
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Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
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