Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
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Cellular uptake, cytotoxicity, and innate immune response of silica-titania hollow nanoparticles based on size and surface functionality.
Wan-Kyu Oh,Sojin Kim,Moonjung Choi,Chanhoi Kim,Yoon Seon Jeong,Bo-Ram Cho,Ji-Sook Hahn,Jyongsik Jang +7 more
TL;DR: This work systematically investigated cellular internalization, toxicity, and innate immune response of HNPs in human breast cancer and mouse alveolar macrophage cells and found size- and surface functionality-dependent nanotoxicity and uptake of HnPs, and lead to HNPS for bioapplications such as drug delivery and imaging probe.
Journal ArticleDOI
Polymer particles that switch shape in response to a stimulus
Jin-Wook Yoo,Samir Mitragotri +1 more
TL;DR: Polymeric particles that are able to switch their shape in real time in a stimulus-responsive manner are reported on, demonstrating the ability of shape-switchable particles in modulating interaction with cells.
Journal ArticleDOI
Size-Dependent Protein-Nanoparticle Interactions in Citrate-Stabilized Gold Nanoparticles: The Emergence of the Protein Corona.
TL;DR: Surface modifications of highly monodisperse citrate-stabilized gold nanoparticles studied and characterized by the combined use of UV-vis spectroscopy, dynamic light scattering, and zeta potential measurements, revealing the significant role that size plays in the kinetics of this process.
Journal ArticleDOI
Secreted Biomolecules Alter the Biological Identity and Cellular Interactions of Nanoparticles
TL;DR: It is shown that cell conditioning induces gold nanoparticle aggregation and changes the protein corona composition in a manner that depends on nanoparticle diameter, surface chemistry, and cell phenotype, showing that dynamic extracellular environments can alter nanoparticle-cell interactions by modulating the biological identity.
Journal ArticleDOI
Carbon dots prepared from ginger exhibiting efficient inhibition of human hepatocellular carcinoma cells
Chi Lin Li,Chung Mao Ou,Chih-Ching Huang,Chih-Ching Huang,Wei Cheng Wu,Wei Cheng Wu,Yi Ping Chen,Tzu-En Lin,Lin-Chen Ho,Chia-Wei Wang,Chung Chien Shih,Hang Cheng Zhou,Ying Chu Lee,Woan Fang Tzeng,Tzeon Jye Chiou,Tzeon Jye Chiou,Sin Tak Chu,Sin Tak Chu,Jinshun Cang,Huan-Tsung Chang +19 more
TL;DR: Fluorescent carbon nanodots from fresh tender ginger juice provide high suppression of the growth of human hepatocellular carcinoma cells (HepG2), with low toxicity to normal mammary epithelial cells (MCF-10A) and normal liver cells (FL83B).
References
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Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
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