Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
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Modeling receptor-mediated endocytosis of polymer-functionalized iron oxide nanoparticles by human macrophages
Oleg Lunov,Vitalii Zablotskii,Tatiana Syrovets,Carlheinz Röcker,Kyrylo Tron,G. Ulrich Nienhaus,G. Ulrich Nienhaus,Thomas Simmet +7 more
TL;DR: A mathematical model of the uptake process of diagnostically used carboxydextran-coated superparamagnetic iron oxide nanoparticles of 60 nm (SPIO) and 20 nm (USPIO) by human macrophages is developed and a new physical parameter 'a' governing the collective uptake process is introduced, a reflecting minimal linear spacing between simultaneously acting neighboring endocytotic pits.
Journal ArticleDOI
Multifunctional nanogels for siRNA delivery.
Michael H. Smith,L. Andrew Lyon +1 more
TL;DR: A subset of the experiences in the design and application of nanogels in the context of drug delivery is summarized, summarizing the relevant characteristics for these materials as delivery vehicles for siRNA.
Journal ArticleDOI
Reprotoxicity of gold, silver, and gold–silver alloy nanoparticles on mammalian gametes
Daniela Tiedemann,Ulrike Taylor,Christoph Rehbock,Jurij Jakobi,Sabine Klein,Wilfried A. Kues,Stephan Barcikowski,Detlef Rath +7 more
TL;DR: M mammalian oocytes were sensitive to silver containing nanoparticles, likely, the delicate process of completing meiosis in maternal gametes features high vulnerability towards nanomaterial derived toxicity.
Journal ArticleDOI
Role of nanoparticle surface functionality in the disruption of model cell membranes.
TL;DR: The results suggest that particles permanently adsorb to bilayers and that only one positively charged particle is required to disrupt a liposome and trigger the leakage of its entire contents in contrast to mellitin molecules, the most widely studied membrane lytic peptide, which requires hundred of molecules to generate leakage.
Journal ArticleDOI
Green synthesis of gold and silver nanoparticles from Cannabis sativa (industrial hemp) and their capacity for biofilm inhibition.
Priyanka Singh,Santosh Pandit,Jørgen Garnæs,Sanja Tunjic,Venkata Raghavendra Subrahmanya Sar Mokkapati,Abida Sultan,Anders Thygesen,Aiga Mackevica,Ramona Valentina Mateiu,Anders Egede Daugaard,Anders Baun,Ivan Mijakovic +11 more
TL;DR: The plant is explored for green and efficient synthesis of gold nanoparticles (AuNPs) and silver nanoparticle (AgNPs), and the stable nature of synthesized nanoparticles has been shown by thermogravimetric analysis and ICP-MS.
References
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Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
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Sophie Laurent,Delphine Forge,Marc Port,Alain Roch,Caroline Robic,Luce Vander Elst,Robert N. Muller +6 more
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Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
TL;DR: This work has shown that addition of PEG and PEG-containing copolymers to the surface of nanoparticles results in an increase in the blood circulation half-life of the particles by several orders of magnitude, and creates a hydrophilic protective layer around the nanoparticles that is able to repel the absorption of opsonin proteins via steric repulsion forces.