Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
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Principles of nanoparticle design for overcoming biological barriers to drug delivery
TL;DR: By successively addressing each of the biological barriers that a particle encounters upon intravenous administration, innovative design features can be rationally incorporated that will create a new generation of nanotherapeutics, realizing a paradigmatic shift in nanoparticle-based drug delivery.
Journal ArticleDOI
Cancer nanomedicine: progress, challenges and opportunities.
TL;DR: Novel engineering approaches are discussed that capitalize on the growing understanding of tumour biology and nano–bio interactions to develop more effective nanotherapeutics for cancer patients.
Journal ArticleDOI
Analysis of nanoparticle delivery to tumours
Stefan Wilhelm,Anthony J. Tavares,Qin Dai,Seiichi Ohta,Seiichi Ohta,Julie Audet,Harold F. Dvorak,Warren C. W. Chan +7 more
TL;DR: This Perspective explores and explains the fundamental dogma of nanoparticle delivery to tumours and answers two central questions: ‘ how many nanoparticles accumulate in a tumour?’ and ‘how does this number affect the clinical translation of nanomedicines?'
Journal ArticleDOI
The golden age: gold nanoparticles for biomedicine
TL;DR: It is argued that gold nanotechnology-enabled biomedicine is not simply an act of 'gilding the (nanomedicinal) lily', but that a new 'Golden Age' of biomedical nanotechnology is truly upon us.
Journal ArticleDOI
A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment
TL;DR: A review of the antibacterial effects of silver nanomaterials, including proposed antibacterial mechanisms and possible toxicity to higher organisms, is presented in this paper, where the authors suggest that further research is warranted given the already widespread and rapidly growing use of silver nanoparticles.
References
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Comparison of the Abilities of Ambient and Manufactured Nanoparticles To Induce Cellular Toxicity According to an Oxidative Stress Paradigm
Tian Xia,Michael Kovochich,Jonathan A. Brant,Matt Hotze,Joan M. Sempf,Terry Oberley,Constantinos Sioutas,Joanne I. Yeh,Mark R. Wiesner,Andre E. Nel +9 more
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Journal ArticleDOI
Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles.
Christian Kirchner,Tim Liedl,Stefan Kudera,Teresa Pellegrino,Almudena Muñoz Javier,Hermann E. Gaub,Sonja Stölzle,Niels Fertig,Wolfgang J. Parak +8 more
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