Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
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Clear and present danger? Engineered nanoparticles and the immune system.
TL;DR: The innate immune system is the first line of defense against microbial invasion and involves the recognition of pathogen-associated molecular patterns by pattern recognition receptors on the surface of phagocytic cells.
Journal ArticleDOI
Uptake of Gold Nanoparticles by Intestinal Epithelial Cells: Impact of Particle Size on Their Absorption, Accumulation, and Toxicity.
TL;DR: The influence of particle size and concentration of gold nanoparticles (AuNPs) on their absorption, accumulation, and cytotoxicity in model intestinal epithelial cells is determined.
Journal ArticleDOI
Proteomics analysis of the mode of antibacterial action of nanoparticles and their interactions with proteins
TL;DR: This review deals with the interaction of NPs with proteins, live cells and organelles, and considers the proteomics analysis by which these interactions affect cytotoxicity, and offers an overview of the cytot toxicity of different NPs using proteomicsAnalysis.
Journal ArticleDOI
Reducing ZnO nanoparticle cytotoxicity by surface modification
Ming-Deng Luo,Cenchao Shen,Bryce Feltis,Bryce Feltis,Lisandra L. Martin,Anthony E. Hughes,Paul F.A. Wright,Terence W. Turney +7 more
TL;DR: It is concluded that the key role of the surface properties of ZnO NPs in controlling cytotoxicity is to regulate cellular nanoparticle uptake rather than altering either intracellular or extracellular Zn dissolution.
Journal ArticleDOI
Bioinspired Soft Microrobots with Precise Magneto-Collective Control for Microvascular Thrombolysis.
Meihua Xie,Wei Zhang,Chengying Fan,Chu Wu,Qishuai Feng,Jiaojiao Wu,Yingze Li,Rui Gao,Li Zhenguang,Qigang Wang,Yu Cheng,Bin He +11 more
TL;DR: The locomotion analyses of BMMs demonstrate the frequency-dependent synchronization under 8 Hz and asynchronization at higher frequencies due to the increased drag torque, which is promising for ultra-minimal invasive thrombolysis.
References
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