Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
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A Safe-by-Design Strategy towards Safer Nanomaterials in Nanomedicines.
TL;DR: The most important categories of nanomaterials with clinical potential and their toxicological mechanisms are summarized and may serve as a starting point to guide the development of more effective safe‐by‐design strategies and to help identify the major knowledge and skill gaps.
Journal ArticleDOI
Toxicogenomic Responses of the Model Organism Caenorhabditis elegans to Gold Nanoparticles
Olga V. Tsyusko,Jason M. Unrine,David J. Spurgeon,Eric M. Blalock,Daniel L. Starnes,Michael T. Tseng,Greg Joice,Paul M. Bertsch +7 more
TL;DR: It is demonstrated that Au-NPs are bioavailable and cause adverse effects to C. elegans by activating both general and specific biological pathways.
Journal ArticleDOI
Graphene oxide/poly-l-lysine assembled layer for adhesion and electrochemical impedance detection of leukemia K562 cancercells
TL;DR: The work demonstrates that a highly biocompatible film of PLL/GO assembled is also expected to be an appropriate matrix for the electrochemical investigation of adhesion, proliferation, apoptosis of other relevant mammalian cells which is not limited to adherent cells, and the study of cell-based biosensors.
Journal ArticleDOI
Experimental Aspects of Colloidal Interactions in Mixed Systems of Liposome and Inorganic Nanoparticle and Their Applications
TL;DR: Recent progress made on the investigations of the interactions in liposome/nanoparticle systems is reviewed focusing on the particularly interesting structures that are formed in these hybrid systems as well as their potential applications.
Journal ArticleDOI
Interactions between engineered nanomaterials and agricultural crops: implications for food safety
TL;DR: More research is urgently needed in the area of ENMs-crop interactions to accurately assess exposure, risk, and overall implications for food safety and also enable guidance development for the sustainable implementation of nanotechnology in agriculture and food production/manufacturing.
References
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Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
TL;DR: This work has shown that addition of PEG and PEG-containing copolymers to the surface of nanoparticles results in an increase in the blood circulation half-life of the particles by several orders of magnitude, and creates a hydrophilic protective layer around the nanoparticles that is able to repel the absorption of opsonin proteins via steric repulsion forces.