Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
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Cell “vision”: complementary factor of protein corona in nanotoxicology
Morteza Mahmoudi,Morteza Mahmoudi,Seyyed Nasirodin Saeedi-Eslami,Mohammad Ali Shokrgozar,Kayhan Azadmanesh,Maryam Hassanlou,Hamid Reza Kalhor,Carmen Burtea,Barbara Rothen-Rutishauser,Sophie Laurent,Sara Sheibani,Hojatollah Vali +11 more
TL;DR: In addition to protein adsorption, the concept of cell "vision" is introduced, which would be recognized as another crucial factor that should be considered for the safe design of any type of nanoparticles that will be used in specific biomedical applications.
Journal ArticleDOI
Mussel-inspired degradable antibacterial polydopamine/silica nanoparticle for rapid hemostasis.
TL;DR: Amorphous nanoscale PDA/SiNP provided a new avenue for design of silica hemostats and nonmetallic ion antimicrobial and blood loss was remarkably reduced in the femoral artery and vein injury, liver injury models.
Journal ArticleDOI
Improved Biocompatibility of Black Phosphorus Nanosheets by Chemical Modification
Guangbo Qu,Wei Liu,Yuetao Zhao,Jie Gao,Tian Xia,Jianbo Shi,Ligang Hu,Wenhua Zhou,Jiejun Gao,Huaiyu Wang,Qian Luo,Qunfang Zhou,Sijin Liu,Xue-Feng Yu,Guibin Jiang +14 more
TL;DR: Compared to bare BPs, BPs with TiL4 modification can efficiently escape from macrophages uptake, and reduce cytotoxicity and proinflammation, and an efficient strategy to further improve the biocompatibility of BPs is proposed.
Journal ArticleDOI
Mesoporous silica nanoparticles loading doxorubicin reverse multidrug resistance: performance and mechanism
TL;DR: The in vivo biodistribution showed that DMNs induced a higher accumulation of DOX in drug resistant tumors than free DOX, suggesting that MSNs could be an effective delivery system to overcome multidrug resistance.
Journal ArticleDOI
Inhalation Exposure to Carbon Nanotubes (CNT) and Carbon Nanofibers (CNF): Methodology and Dosimetry
TL;DR: The current literature on pulmonary exposure to CNT/CNF and associated effects is summarized; recommendations and conclusions are provided that address test guideline modifications for rodent inhalation studies that will improve dosimetric extrapolation modeling for hazard and risk characterization based on the analysis of exposure-dose-response relationships.
References
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Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
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