Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
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Surface-charge-dependent cell localization and cytotoxicity of cerium oxide nanoparticles.
TL;DR: The results indicate that the differential surface-charge-dependent localization of nanoceria in normal and cancer cells plays a critical role in the nanoparticles' toxicity profile.
Journal ArticleDOI
Biocompatibility of engineered nanoparticles for drug delivery.
Sheva Naahidi,Mousa Jafari,Faramarz Edalat,Faramarz Edalat,Kevin Raymond,Ali Khademhosseini,Ali Khademhosseini,Ali Khademhosseini,Pu Chen +8 more
TL;DR: The data existing in the literature regarding biocompatibility of nanoparticles for drug delivery applications is discussed, and the various types of nanoparticle used in drug delivery systems are reviewed while addressing new challenges and research directions.
Journal ArticleDOI
Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications
TL;DR: A State-of-the-art use of PEG in therapeutic applications, its clinical status and commercial use is summarized, and toxicities related to different PEG grades and related impurities are discussed in this review.
Journal ArticleDOI
Cellular toxicity of inorganic nanoparticles: Common aspects and guidelines for improved nanotoxicity evaluation
Stefaan J. Soenen,Pilar Rivera-Gil,Jose-Maria Montenegro,Wolfgang J. Parak,Stefaan C. De Smedt,Kevin Braeckmans +5 more
TL;DR: An overview of the cytotoxic effects of commonly used inorganic NPs: quantum dots, gold and iron oxide nanoparticles is presented and suggestions are made on how to optimize NP design in view of minimal cytotoxicity.
Journal ArticleDOI
Mesoporous silica nanoparticles in medicine--recent advances.
TL;DR: This review covers recent advances related to the therapeutic use of mesoporous silica nanoparticles administered intravenously, intraperitoneally or locally and critically discusses burning questions especially related to experimental design of in vivo studies to enable a fast transition to clinical trials of this promising drug delivery platform.
References
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Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
TL;DR: This work has shown that addition of PEG and PEG-containing copolymers to the surface of nanoparticles results in an increase in the blood circulation half-life of the particles by several orders of magnitude, and creates a hydrophilic protective layer around the nanoparticles that is able to repel the absorption of opsonin proteins via steric repulsion forces.