Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TLDR
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.Abstract:
Rapid growth in nanotechnology is increasing the likelihood of engineered nanomaterials coming into contact with humans and the environment. Nanoparticles interacting with proteins, membranes, cells, DNA and organelles establish a series of nanoparticle/biological interfaces that depend on colloidal forces as well as dynamic biophysicochemical interactions. These interactions lead to the formation of protein coronas, particle wrapping, intracellular uptake and biocatalytic processes that could have biocompatible or bioadverse outcomes. For their part, the biomolecules may induce phase transformations, free energy releases, restructuring and dissolution at the nanomaterial surface. Probing these various interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings. This knowledge is important from the perspective of safe use of nanomaterials.read more
Citations
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Effect of Nanoparticles on the Biochemical and Behavioral Aging Phenotype of the Nematode Caenorhabditis elegans
TL;DR: Screening of different nanomaterials for their effects on protein solubility shows that polystyrene or silver NPs do not induce accumulation of ubiquitinated proteins suggesting that alteration of protein homeostasis is a unique property of silica NPs.
Journal ArticleDOI
Physicochemical characterization of nanoparticles and their behavior in the biological environment.
Lennart Treuel,Lennart Treuel,K. A. Eslahian,Dominic Docter,Thomas Lang,Reinhard Zellner,Karin Nienhaus,Gerd Ulrich Nienhaus,Gerd Ulrich Nienhaus,Roland H. Stauber,Michael Maskos +10 more
TL;DR: The present article discusses some of the challenges with characterization and behavior of nanoparticles that are associated with their presence in chemically complex biological environments and focuses on the stability of colloids as well as on the formation and characteristics of protein coronae that have recently been shown to significantly modify the properties of pristine particles.
Journal ArticleDOI
Effects of copper nanoparticle exposure on host defense in a murine pulmonary infection model
Jong Sung Kim,Andrea Adamcakova-Dodd,Patrick T. O'Shaughnessy,Vicki H. Grassian,Peter S. Thorne +4 more
TL;DR: Exposure to copper (Cu) NPs impaired host defense against bacterial lung infections and induced a dose-dependent decrease in bacterial clearance in which even the lowest dose demonstrated significantly lower clearance than observed in sham-exposed mice.
Journal ArticleDOI
Learning from nature: binary cooperative complementary nanomaterials.
TL;DR: In this Review, nature-inspired binary cooperative complementary nanomaterials (BCCNMs), consisting of two components with entirely opposite physiochemical properties at the nanoscale, are presented as a novel concept for the building of promising materials.
Journal ArticleDOI
Nanotoxicology and Nanosafety: Safety-by-Design and Testing at a Glance
Aleksandra Zielińska,Aleksandra Zielińska,Beatriz Costa,Maria V. Ferreira,Diogo Miguéis,Jéssica M. S. Louros,Alessandra Durazzo,Massimo Lucarini,Piotr Eder,Marco Vinícius Chaud,Margreet Morsink,Margreet Morsink,Niels Willemen,Niels Willemen,Patrícia Severino,Antonello Santini,Eliana B. Souto,Eliana B. Souto +17 more
TL;DR: A detailed introduction on nanomaterials and their most frequently uses, followed by the critical risk aspects related to regulatory uses and commercialization, is provided and the significance of nano-security for both risk assessment and environmental nanosafety is described.
References
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Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
TL;DR: This work has shown that addition of PEG and PEG-containing copolymers to the surface of nanoparticles results in an increase in the blood circulation half-life of the particles by several orders of magnitude, and creates a hydrophilic protective layer around the nanoparticles that is able to repel the absorption of opsonin proteins via steric repulsion forces.