Understanding Dopaminergic Cell Death Pathways in Parkinson Disease.
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TLDR
A synthetic overview of cell-autonomous mechanisms that are likely to participate in DA cell death in both sporadic and inherited forms of the disease is presented and it is shown how these mechanisms may mutually cooperate to promote neuronal death.About:
This article is published in Neuron.The article was published on 2016-05-18 and is currently open access. It has received 418 citations till now. The article focuses on the topics: Substantia nigra & Dopaminergic Cell.read more
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Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
Fiona M. Menzies,Angeleen Fleming,Andrea Caricasole,Carla F. Bento,Stephen P. Andrews,Avraham Ashkenazi,Jens Füllgrabe,Anne Jackson,Maria Jimenez Sanchez,Cansu Karabiyik,Floriana Licitra,Ana Lopez Ramirez,Mariana Pavel,Claudia Puri,Maurizio Renna,Thomas Ricketts,Lars Schlotawa,Mariella Vicinanza,Hyeran Won,Ye Zhu,John Skidmore,David C. Rubinsztein +21 more
TL;DR: How autophagy upregulation may be a therapeutic strategy in a wide range of neurodegenerative conditions is described and possible pathways and druggable targets that may be suitable for this objective are considered.
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The SH-SY5Y cell line in Parkinson's disease research: a systematic review
TL;DR: An overview of the cell source, culture conditions, differentiation protocols, methods/approaches used to mimic PD and the preclinical validation of the SH-SY5Y findings by employing alternative cellular and animal models is described.
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Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy
Jose A. Obeso,Maria Stamelou,Maria Stamelou,Christopher G. Goetz,W. Poewe,Anthony E. Lang,Anthony E. Lang,Daniel Weintraub,David J. Burn,Glenda M. Halliday,Glenda M. Halliday,Erwan Bezard,Erwan Bezard,Serge Przedborski,Stéphane Lehéricy,David J. Brooks,David J. Brooks,John C. Rothwell,Mark Hallett,Mahlon R. DeLong,Connie Marras,Caroline M. Tanner,Caroline M. Tanner,G. W. Ross,J. W. Langston,Christine Klein,V. Bonifati,Joseph Jankovic,Andres M. Lozano,Günther Deuschl,Hagai Bergman,Eduard Tolosa,Mayela Rodríguez-Violante,Stanley Fahn,Ronald B. Postuma,Daniela Berg,Kenneth Marek,David G. Standaert,Dalton James Surmeier,C. W. Olanow,Jeffrey H. Kordower,Paolo Calabresi,Anthony H.V. Schapira,A. J. Stoessl,A. J. Stoessl +44 more
TL;DR: This multiple‐author article provides a historical state‐of‐the‐art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.
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Mitochondrial Dysfunction in Parkinson's Disease: New Mechanistic Insights and Therapeutic Perspectives.
TL;DR: Increasing evidence supports the critical role for mitochondrial dysfunction in the development of sporadic PD, while the involvement of familial PD-related genes in the regulation of mitochondrial biology has been expanded by the discovery of new mitochondria-associated disease loci and the identification of their novel functions.
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Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments
TL;DR: A comprehensive overview of the current understanding of the molecular signaling pathways involved in Parkinson’s disease, particularly within the context of how genetic and environmental factors contribute to the initiation and progression of this disease is provided.
References
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Mutation in the α-synuclein gene identified in families with Parkinson's disease
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Maria Grazia Spillantini,Marie L. Schmidt,Virginia M.-Y. Lee,John Q. Trojanowski,Ross Jakes,Michel Goedert +5 more
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α-Synuclein Locus Triplication Causes Parkinson's Disease
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