Unraveling the complexities of the HDL lipidome
TLDR
The HDL lipidome has been used to identify clinically relevant HDL subpopulations and to identify beneficial subspecies within the circulating HDL pool using this approach as mentioned in this paper, which can also contribute to the identification of biomarkers of normal and deficient HDL functionality.About:
This article is published in Journal of Lipid Research.The article was published on 2013-11-01 and is currently open access. It has received 290 citations till now. The article focuses on the topics: Lipidome & Lipidomics.read more
Citations
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Journal ArticleDOI
Lipidomics: Techniques, Applications, and Outcomes Related to Biomedical Sciences
Kui Yang,Xianlin Han,Xianlin Han +2 more
TL;DR: This review provides a timely update on very recent applications of lipidomics in health and disease and compares mass spectrometry-based techniques for analysis of lipids.
Journal ArticleDOI
HDL-targeted therapies: progress, failures and future
TL;DR: The HDL hypothesis is examined in molecular and mechanistic terms, focusing on features that have been addressed, those that remain to be tested, and potential new targets for future pharmacological interventions.
Journal ArticleDOI
From Lipids to Inflammation New Approaches to Reducing Atherosclerotic Risk
Michael D. Shapiro,Sergio Fazio +1 more
TL;DR: The demonstration of clinical benefits from the addition of ezetimibe to statin therapy in subjects with acute coronary syndromes has renewed the enthusiasm for the cholesterol hypothesis and the hope that additional agents that lower low-density lipoprotein will decrease risk of atherosclerotic cardiovascular disease.
Journal ArticleDOI
High-Density Lipoproteins : Multifunctional but Vulnerable Protections from Atherosclerosis
TL;DR: The answer to this question is a prerequisite to exploit HDL for the development of anti-atherogenic drugs as well as of diagnostic biomarkers for the identification, personalized treatment stratification, and monitoring of patients at increased cardiovascular risk.
The Role of Lipids and Lipoproteins in Atherosclerosis
MacRae F. Linton,Patricia G. Yancey,Sean S. Davies,W. Gray Jerome,Edward F Linton,Wen-Liang Song,Amanda C. Doran,Kasey C. Vickers +7 more
TL;DR: Lowering LDL-cholesterol with statins reduces risk for cardiovascular events, providing ultimate proof of the cholesterol hypothesis and the current landscape of HDL metabolism.
References
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Role of Oxidative Modifications in Atherosclerosis
Roland Stocker,John F. Keaney +1 more
TL;DR: An "oxidative response to inflammation" model is proposed as a means of reconciling the response-to-injury and oxidative modification hypotheses of atherosclerosis.
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Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host.
Weerapan Khovidhunkit,Min Sun Kim,Riaz A. Memon,Judy K. Shigenaga,Arthur H. Moser,Kenneth R. Feingold,Carl Grunfeld +6 more
TL;DR: APR-induced alterations initially protect the host from the harmful effects of bacteria, viruses, and parasites, however, if prolonged, these changes in the structure and function of lipoproteins will contribute to atherogenesis.
Journal ArticleDOI
Lipidomics reveals a remarkable diversity of lipids in human plasma
Oswald Quehenberger,Aaron M. Armando,Alex Brown,Stephen B. Milne,David S. Myers,Alfred H. Merrill,Sibali Bandyopadhyay,Kristin N. Jones,Samuel Kelly,Rebecca L. Shaner,Cameron Sullards,Elaine Wang,Robert C. Murphy,Robert M. Barkley,Thomas J. Leiker,Christian R. H. Raetz,Ziqiang Guan,Gregory M. Laird,David A. Six,David W. Russell,Jeffrey G. McDonald,Shankar Subramaniam,Eoin Fahy,Edward A. Dennis +23 more
TL;DR: The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids and to quantitatively assessed the levels of over 500 distinct molecular species distributed among the main lipid categories.
Journal ArticleDOI
Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
Rajita Pappu,Susan R. Schwab,Ivo Cornelissen,João Pereira,Jean B. Regard,Ying Xu,Eric Camerer,Yaowu Zheng,Yong Huang,Jason G. Cyster,Shaun R. Coughlin +10 more
TL;DR: Separate sources provide S1P to plasma and lymph to help lymphocytes exit the low-S1P environment of lymphoid organs, and disruption of compartmentalized S 1P signaling is a plausible mechanism by which S1p-receptor-1 agonists function as immunosuppressives.
Journal ArticleDOI
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
Jerzy Roch Nofer,Markus van der Giet,Markus Tölle,Iza Wolinska,Karin von Wnuck Lipinski,Hideo A. Baba,Uwe J. F. Tietge,Axel Gödecke,Isao Ishii,Burkhard Kleuser,Michael Schäfers,Manfred Fobker,Walter Zidek,Gerd Assmann,Jerold Chun,Bodo Levkau,Bodo Levkau +16 more
TL;DR: HDL is identified as a carrier of bioactive lysophospholipids that regulate vascular tone via S1P3-mediated NO release and induces vasodilation in isolated aortae via intracellular Ca2+ mobilization and Akt-mediated eNOS phosphorylation.
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