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Alexandra Zhernakova
Researcher at University Medical Center Groningen
Publications - 242
Citations - 36684
Alexandra Zhernakova is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Microbiome & Population. The author has an hindex of 71, co-authored 209 publications receiving 26730 citations. Previous affiliations of Alexandra Zhernakova include Northwestern University & Boston Children's Hospital.
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Journal ArticleDOI
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
Simone Wahl,Alexander W. Drong,Benjamin Lehne,Marie Loh,Marie Loh,Marie Loh,William R. Scott,William R. Scott,Sonja Kunze,Pei-Chien Tsai,Janina S. Ried,Weihua Zhang,Weihua Zhang,Youwen Yang,Sili Tan,Giovanni Fiorito,Lude Franke,Simonetta Guarrera,Silva Kasela,Jennifer Kriebel,Rebecca C Richmond,Marco Adamo,Uzma Afzal,Uzma Afzal,Mika Ala-Korpela,Mika Ala-Korpela,Mika Ala-Korpela,Benedetta Albetti,Ole Ammerpohl,Jane F. Apperley,Marian Beekman,Pier Alberto Bertazzi,S. Lucas Black,Christine Blancher,Marc Jan Bonder,Mario Brosch,Maren Carstensen-Kirberg,Anton J. M. de Craen,Simon de Lusignan,Abbas Dehghan,Mohamed Elkalaawy,Krista Fischer,Oscar H. Franco,Tom R. Gaunt,Jochen Hampe,Majid Hashemi,Aaron Isaacs,Andrew Jenkinson,Sujeet Jha,Norihiro Kato,Vittorio Krogh,Michael Laffan,Christa Meisinger,Thomas Meitinger,Zuan Yu Mok,Valeria Motta,Hong Kiat Ng,Zacharoula Nikolakopoulou,Georgios Nteliopoulos,Salvatore Panico,Natalia Pervjakova,Holger Prokisch,Wolfgang Rathmann,Michael Roden,Federica Rota,Michelle Ann Rozario,Johanna K. Sandling,Johanna K. Sandling,Clemens Schafmayer,Katharina Schramm,Reiner Siebert,Reiner Siebert,P. Eline Slagboom,Pasi Soininen,Pasi Soininen,Lisette Stolk,Konstantin Strauch,E-Shyong Tai,Letizia Tarantini,Barbara Thorand,Ettje F. Tigchelaar,Rosario Tumino,André G. Uitterlinden,Cornelia M. van Duijn,Joyce B. J. van Meurs,Paolo Vineis,Ananda R. Wickremasinghe,Cisca Wijmenga,Tsun-Po Yang,Wei Yuan,Wei Yuan,Alexandra Zhernakova,Rachel L. Batterham,George Davey Smith,Panos Deloukas,Panos Deloukas,Panos Deloukas,Bastiaan T. Heijmans,Christian Herder,Albert Hofman,Cecilia M. Lindgren,Cecilia M. Lindgren,Lili Milani,Pim van der Harst,Annette Peters,Thomas Illig,Caroline L Relton,Melanie Waldenberger,Marjo-Riitta Järvelin,Valentina Bollati,Richie Soong,Tim D. Spector,James Scott,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Paul Elliott,Paul Elliott,Jordana T. Bell,Giuseppe Matullo,Christian Gieger,Jaspal S. Kooner,Harald Grallert,John C. Chambers +123 more
TL;DR: In this article, the authors used epigenome-wide association to show that body mass index (BMI), a key measure of adiposity, is associated with widespread changes in DNA methylation.
Journal ArticleDOI
Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases.
Serena Sanna,Natalie R. van Zuydam,Natalie R. van Zuydam,Anubha Mahajan,Alexander Kurilshikov,Arnau Vich Vila,Urmo Võsa,Zlatan Mujagic,Ad A.M. Masclee,Daisy Jonkers,Marije Oosting,Leo A. B. Joosten,Mihai G. Netea,Lude Franke,Alexandra Zhernakova,Jingyuan Fu,Cisca Wijmenga,Mark I. McCarthy,Mark I. McCarthy +18 more
TL;DR: Evidence of a causal effect of the gut microbiome on metabolic traits is shown and the use of MR is supported as a means to elucidate causal relationships from microbiome-wide association findings.
Journal ArticleDOI
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
Steve Eyre,John Bowes,John Bowes,Dorothée Diogo,Dorothée Diogo,Annette Lee,Anne Barton,Anne Barton,Paul Martin,Paul Martin,Alexandra Zhernakova,Alexandra Zhernakova,Eli A. Stahl,Eli A. Stahl,Sebastien Viatte,Sebastien Viatte,Kate McAllister,Kate McAllister,Christopher I. Amos,Leonid Padyukov,René E. M. Toes,Tom W J Huizinga,Cisca Wijmenga,Gosia Trynka,Lude Franke,Harm-Jan Westra,Lars Alfredsson,Xinli Hu,Cynthia Sandor,Cynthia Sandor,Paul I.W. de Bakker,Sonia Davila,Chiea Chuen Khor,Khai Koon Heng,Robert Andrews,Sarah Edkins,Sarah E. Hunt,Cordelia Langford,Deborah P M Symmons,Deborah P M Symmons,Genomics Study Syndicate,Patrick Concannon,Suna Onengut-Gumuscu,Stephen S. Rich,Panos Deloukas,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Lisbeth Ärlsetig,Javier Martin,Solbritt Rantapää-Dahlqvist,Robert M. Plenge,Robert M. Plenge,Soumya Raychaudhuri,Lars Klareskog,Peter K. Gregersen,Jane Worthington,Jane Worthington +56 more
TL;DR: This study illustrates the advantages of dense SNP mapping analysis to inform subsequent functional investigations and refined the peak of association to a single gene for 19 loci, identified secondary independent effects at 6 loci and identified association to low-frequency variants at 4 loci.
Journal ArticleDOI
The effect of host genetics on the gut microbiome
Marc Jan Bonder,Alexander Kurilshikov,Alexander Kurilshikov,Ettje F. Tigchelaar,Zlatan Mujagic,Floris Imhann,Arnau Vich Vila,Patrick Deelen,Tommi Vatanen,Tommi Vatanen,Melanie Schirmer,Melanie Schirmer,Sanne P. Smeekens,Daria V. Zhernakova,Soesma A Jankipersadsing,Martin Jaeger,Marije Oosting,María Carmen Cenit,Ad A.M. Masclee,Morris A. Swertz,Yang Li,Vinod Kumar,Leo A. B. Joosten,Hermie J. M. Harmsen,Rinse K. Weersma,Lude Franke,Marten H. Hofker,Ramnik J. Xavier,Daisy Jonkers,Mihai G. Netea,Cisca Wijmenga,Jingyuan Fu,Alexandra Zhernakova +32 more
TL;DR: The results demonstrate the importance of understanding host–microbe interactions to gain better insight into human health and demonstrate the influence of host genetics on microbial species, pathways and gene ontology categories on the basis of metagenomic sequencing in 1,514 subjects.
Journal ArticleDOI
Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease
Floris Imhann,Arnau Vich Vila,Marc Jan Bonder,Jingyuan Fu,Dirk Gevers,Marijn C. Visschedijk,Lieke M. Spekhorst,Rudi Alberts,Lude Franke,Hendrik M. van Dullemen,Rinze W. F. ter Steege,Curtis Huttenhower,Curtis Huttenhower,Gerard Dijkstra,Ramnik J. Xavier,Ramnik J. Xavier,Eleonora A. M. Festen,Cisca Wijmenga,Alexandra Zhernakova,Rinse K. Weersma +19 more
TL;DR: It is shown for the first time that genetic risk variants associated with IBD influence the gut microbiota in healthy individuals.