Clemens Schafmayer

TL;DR: Mboat7 deficiency in mice and human points to an inflammation-independent pathway of liver fibrosis that may be mediated by lipid signalling and a potentially targetable treatment option in NAFLD.

TL;DR: Adiposity was associated with numerous metabolic alterations, but none of these explained associations between adiposity and CRC, and it is suggested that higher BMI more greatly raises CRC risk among men, whereas higher WHR more greatly rises CRCrisk among women.

TL;DR: In this article, the authors analyzed the global incidence, mortality, prevalence, and contributing risk factors of the 6 major GI cancer entities [esophageal cancer (EC), gastric cancer (GC), liver cancer (LC), pancreatic cancer (PC), colon cancer, and rectal cancer].

TL;DR: PendiXcan as mentioned in this paper uses cis-regulatory variant predictors to impute expression and perform gene-level association tests in GWAS without directly measured transcriptomes, finding statistically significant associations using colon transcriptome models with TRIM4 and PYGL.

TL;DR: Using high-resolution shotgun mass spectrometry, Wang et al. as mentioned in this paper quantified the molar abundance of 316 species from 22 major lipid classes in liver biopsies of 365 patients, including nonsteatotic patients with normal or excessive weight, patients diagnosed with NAFL (nonalcoholic fatty liver) or NASH (nonaltic steatohepatitis), and patients bearing common mutations of NAFLD-related protein factors.