C
Clemens Schafmayer
Researcher at University of Rostock
Publications - 26
Citations - 351
Clemens Schafmayer is an academic researcher from University of Rostock. The author has contributed to research in topics: Liver disease & Steatosis. The author has an hindex of 6, co-authored 26 publications receiving 111 citations. Previous affiliations of Clemens Schafmayer include German Cancer Research Center & University of Virginia.
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Journal ArticleDOI
Loss of hepatic Mboat7 leads to liver fibrosis
Veera Raghavan Thangapandi,Oskar Knittelfelder,Mario Brosch,Eleonora Patsenker,Olga Vvedenskaya,Stephan Buch,Sebastian Hinz,Alexander Hendricks,Marina Nati,A Herrmann,Devavrat Ravindra Rekhade,Thomas Berg,Madlen Matz-Soja,Klaus Huse,Edda Klipp,Josch K. Pauling,Judith A. H. Wodke,Jacobo Miranda Ackerman,Malte von Bonin,Elmar Aigner,Christian Datz,Witigo von Schönfels,S Nehring,Sebastian Zeissig,Christoph Röcken,Andreas Dahl,Triantafyllos Chavakis,Felix Stickel,Andrej Shevchenko,Clemens Schafmayer,Jochen Hampe,Pallavi Subramanian +31 more
TL;DR: Mboat7 deficiency in mice and human points to an inflammation-independent pathway of liver fibrosis that may be mediated by lipid signalling and a potentially targetable treatment option in NAFLD.
Journal ArticleDOI
Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study
Caroline J. Bull,Joshua A. Bell,Neil Murphy,Eleanor Sanderson,George Davey Smith,Nicholas J. Timpson,Barbara L. Banbury,Demetrius Albanes,Sonja I. Berndt,Stéphane Bézieau,D. Timothy Bishop,Hermann Brenner,Daniel D. Buchanan,Daniel D. Buchanan,Andrea N. Burnett-Hartman,Graham Casey,Sergi Castellví-Bel,Andrew T. Chan,Jenny Chang-Claude,Jenny Chang-Claude,Amanda J. Cross,Albert de la Chapelle,Jane C. Figueiredo,Jane C. Figueiredo,Steven Gallinger,Susan M. Gapstur,Graham G. Giles,Graham G. Giles,Graham G. Giles,Stephen B. Gruber,Andrea Gsur,Jochen Hampe,Heather Hampel,Tabitha A. Harrison,Michael Hoffmeister,Li Hsu,Li Hsu,Wen-Yi Huang,Jeroen R. Huyghe,Mark A. Jenkins,Corinne E. Joshu,Temitope O. Keku,Tilman Kühn,Sun-Seog Kweon,Loic Le Marchand,Christopher I. Li,Li Li,Annika Lindblom,Annika Lindblom,Vicente Martín,Anne M. May,Roger L. Milne,Roger L. Milne,Roger L. Milne,Victor Moreno,Polly A. Newcomb,Polly A. Newcomb,Kenneth Offit,Kenneth Offit,Shuji Ogino,Amanda I. Phipps,Amanda I. Phipps,Elizabeth A. Platz,John D. Potter,Conghui Qu,J. Ramón Quirós,Gad Rennert,Elio Riboli,Lori C. Sakoda,Lori C. Sakoda,Clemens Schafmayer,Robert E. Schoen,Martha L. Slattery,Catherine M. Tangen,Kostas Tsilidis,Kostas Tsilidis,Cornelia M. Ulrich,Fränzel J.B. van Duijnhoven,Bethany Van Guelpen,Kala Visvanathan,Pavel Vodicka,Pavel Vodicka,Pavel Vodicka,Ludmila Vodickova,Ludmila Vodickova,Ludmila Vodickova,Hansong Wang,Emily White,Emily White,Alicja Wolk,Michael O. Woods,Anna H. Wu,Peter T. Campbell,Wei Zheng,Ulrike Peters,Emma E. Vincent,Marc J. Gunter +96 more
TL;DR: Adiposity was associated with numerous metabolic alterations, but none of these explained associations between adiposity and CRC, and it is suggested that higher BMI more greatly raises CRC risk among men, whereas higher WHR more greatly rises CRCrisk among women.
Journal ArticleDOI
A global assessment of recent trends in gastrointestinal cancer and lifestyle-associated risk factors
TL;DR: In this article, the authors analyzed the global incidence, mortality, prevalence, and contributing risk factors of the 6 major GI cancer entities [esophageal cancer (EC), gastric cancer (GC), liver cancer (LC), pancreatic cancer (PC), colon cancer, and rectal cancer].
Journal ArticleDOI
Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer.
Stephanie A. Bien,Stephanie A. Bien,Yu Ru Su,Yu Ru Su,David V. Conti,David V. Conti,Tabitha A. Harrison,Tabitha A. Harrison,Conghui Qu,Conghui Qu,Xingyi Guo,Xingyi Guo,Yingchang Lu,Yingchang Lu,Demetrius Albanes,Paul L. Auer,Paul L. Auer,Barbara L. Banbury,Barbara L. Banbury,Sonja I. Berndt,Stéphane Bezieau,Hermann Brenner,Daniel D. Buchanan,Bette J. Caan,Bette J. Caan,Peter T. Campbell,Peter T. Campbell,Christopher S. Carlson,Christopher S. Carlson,Andrew T. Chan,Andrew T. Chan,Andrew T. Chan,Jenny Chang-Claude,Jenny Chang-Claude,Jenny Chang-Claude,Sai Chen,Sai Chen,Charles M. Connolly,Charles M. Connolly,Douglas F. Easton,Douglas F. Easton,Edith J.M. Feskens,Edith J.M. Feskens,Steven Gallinger,Steven Gallinger,Graham G. Giles,Graham G. Giles,Graham G. Giles,Marc J. Gunter,Marc J. Gunter,Jochen Hampe,Jochen Hampe,Jeroen R. Huyghe,Jeroen R. Huyghe,Michael Hoffmeister,Michael Hoffmeister,Thomas J. Hudson,Thomas J. Hudson,Thomas J. Hudson,Eric J. Jacobs,Eric J. Jacobs,Mark A. Jenkins,Mark A. Jenkins,Ellen Kampman,Ellen Kampman,Hyun Min Kang,Hyun Min Kang,Tilman Kühn,Tilman Kühn,Sébastien Küry,Flavio Lejbkowicz,Flavio Lejbkowicz,Loic Le Marchand,Loic Le Marchand,RL Milne,RL Milne,RL Milne,Li Li,Li Li,Christopher I. Li,Christopher I. Li,Annika Lindblom,Annika Lindblom,Annika Lindblom,Noralane M. Lindor,Noralane M. Lindor,Vicente Martín,Vicente Martín,Caroline McNeil,Caroline McNeil,Marilena Melas,Marilena Melas,Victor Moreno,Polly A. Newcomb,Polly A. Newcomb,Kenneth Offit,Kenneth Offit,Paul D.P. Pharaoh,Paul D.P. Pharaoh,John D. Potter,John D. Potter,Chenxu Qu,Chenxu Qu,Elio Riboli,Elio Riboli,Gad Rennert,Gad Rennert,Núria Sala,Clemens Schafmayer,Peter C. Scacheri,Peter C. Scacheri,Stephanie L. Schmit,Gianluca Severi,Gianluca Severi,Martha L. Slattery,Martha L. Slattery,Joshua D. Smith,Joshua D. Smith,Antonia Trichopoulou,Antonia Trichopoulou,Rosario Tumino,Cornelia M. Ulrich,Cornelia M. Ulrich,Fränzel J. B. van Duijnhoven,Fränzel J. B. van Duijnhoven,Bethany Van Guelpen,Bethany Van Guelpen,Stephanie J. Weinstein,Emily White,Emily White,Alicja Wolk,Alicja Wolk,Alicja Wolk,Michael O. Woods,Michael O. Woods,Anna H. Wu,Anna H. Wu,Gonçalo R. Abecasis,Gonçalo R. Abecasis,Graham Casey,Graham Casey,Deborah A. Nickerson,Deborah A. Nickerson,Stephen B. Gruber,Stephen B. Gruber,Li Hsu,Li Hsu,Wei Zheng,Wei Zheng,Ulrike Peters,Ulrike Peters +150 more
TL;DR: PendiXcan as mentioned in this paper uses cis-regulatory variant predictors to impute expression and perform gene-level association tests in GWAS without directly measured transcriptomes, finding statistically significant associations using colon transcriptome models with TRIM4 and PYGL.
Journal ArticleDOI
Nonalcoholic fatty liver disease stratification by liver lipidomics.
Olga Vvedenskaya,Tim Daniel Rose,Oskar Knittelfelder,Alessandra Palladini,Judith Andrea Heidrun Wodke,Kai Schuhmann,Jacobo Miranda Ackerman,Yuting Wang,Canan Has,Mario Brosch,Veera Raghavan Thangapandi,Stephan Buch,Thomas Züllig,Jürgen Hartler,Harald Köfeler,Christoph Röcken,Ünal Coskun,Edda Klipp,Witigo von Schoenfels,Justus Gross,Clemens Schafmayer,Jochen Hampe,Josch Konstantin Pauling,Andrej Shevchenko +23 more
TL;DR: Using high-resolution shotgun mass spectrometry, Wang et al. as mentioned in this paper quantified the molar abundance of 316 species from 22 major lipid classes in liver biopsies of 365 patients, including nonsteatotic patients with normal or excessive weight, patients diagnosed with NAFL (nonalcoholic fatty liver) or NASH (nonaltic steatohepatitis), and patients bearing common mutations of NAFLD-related protein factors.