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Patrizia Rizzu
Researcher at German Center for Neurodegenerative Diseases
Publications - 101
Citations - 17635
Patrizia Rizzu is an academic researcher from German Center for Neurodegenerative Diseases. The author has contributed to research in topics: Frontotemporal dementia & Gene. The author has an hindex of 44, co-authored 92 publications receiving 15304 citations. Previous affiliations of Patrizia Rizzu include Erasmus University Medical Center & VU University Amsterdam.
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Journal ArticleDOI
Genome-wide association study confirms extant PD risk loci among the Dutch
Javier Simón-Sánchez,Jacobus J. van Hilten,Bart P.C. van de Warrenburg,Bart Post,Henk W. Berendse,Sampath Arepalli,Dena G. Hernandez,Rob M.A. de Bie,Daan C. Velseboer,Hans Scheffer,B.R. Bloem,Karin van Dijk,Fernando Rivadeneira,Fernando Rivadeneira,Albert Hofman,André G. Uitterlinden,André G. Uitterlinden,Patrizia Rizzu,Zoltán Bochdanovits,Andrew B. Singleton,Peter Heutink +20 more
TL;DR: Direct replication of SNPs within SNCA and BST1 confirmed these two genes to be associated with PD in the Netherlands and post-hoc analysis confirmed GAK/DGKQ, HLA and MAPT as PD risk loci among the Dutch.
Journal ArticleDOI
The Netherlands Twin Register biobank: a resource for genetic epidemiological studies.
Gonneke Willemsen,Eco J. C. de Geus,Meike Bartels,C. E. M. Toos van Beijsterveldt,Andrew Brooks,G. Frederique Estourgie-van Burk,Douglas A. Fugman,Chantal Hoekstra,Jouke-Jan Hottenga,Kees Kluft,Piet Meijer,Grant W. Montgomery,Patrizia Rizzu,David Sondervan,August B. Smit,Sabine Spijker,H. Eka D. Suchiman,Jay A. Tischfield,Thomas Lehner,P. Eline Slagboom,Dorret I. Boomsma +20 more
TL;DR: The NTR biobank provides a valuable resource for the study of genetic determinants of individual differences in mental and physical health and offers opportunities for DNA-based and gene expression studies as well as for future metabolomic and proteomic projects.
Journal ArticleDOI
FANTOM5 CAGE profiles of human and mouse samples
Shuhei Noguchi,Takahiro Arakawa,Shiro Fukuda,Masaaki Furuno,Akira Hasegawa,Fumi Hori,Sachi Ishikawa-Kato,Kaoru Kaida,Ai Kaiho,Mutsumi Kanamori-Katayama,Tsugumi Kawashima,Miki Kojima,Atsutaka Kubosaki,Ri Ichiroh Manabe,Mitsuyoshi Murata,Sayaka Nagao-Sato,Kenichi Nakazato,Noriko Ninomiya,Hiromi Nishiyori-Sueki,Shohei Noma,Eri Saijyo,Akiko Saka,Mizuho Sakai,Christophe Simon,Naoko Suzuki,Michihira Tagami,Shoko Watanabe,Shigehiro Yoshida,Peter Arner,Richard A Axton,Magda Babina,J Kenneth Baillie,Timothy C. Barnett,Anthony G Beckhouse,Antje Blumenthal,Beatrice Bodega,Alessandro Bonetti,James Briggs,Frank Brombacher,Frank Brombacher,Ailsa J Carlisle,Hans Clevers,Hans Clevers,Carrie A. Davis,Michael Detmar,Taeko Dohi,B. Albert S. Edge,Matthias Edinger,Anna Ehrlund,Karl Ekwall,Mitsuhiro Endoh,Hideki Enomoto,Afsaneh Eslami,Michela Fagiolini,Lynsey Fairbairn,Mary C. Farach-Carson,Geoffrey J. Faulkner,Carmelo Ferrai,Malcolm E. Fisher,Lesley M. Forrester,Rie Fujita,Jun Ichi Furusawa,Teunis B. H. Geijtenbeek,Thomas R. Gingeras,Dan Goldowitz,Sven Guhl,Reto Guler,Reto Guler,Stefano Gustincich,Stefano Gustincich,Thomas J. Ha,Masahide Hamaguchi,Mitsuko Hara,Yuki Hasegawa,Meenhard Herlyn,Peter Heutink,Kelly J Hitchens,David A. Hume,Tomokatsu Ikawa,Yuri Ishizu,Chieko Kai,Hiroshi Kawamoto,Yuki I. Kawamura,Judith S. Kempfle,Tony J. Kenna,Juha Kere,Juha Kere,Levon M. Khachigian,Toshio Kitamura,Sarah Klein,S. Peter Klinken,Alan J. Knox,Soichi Kojima,Haruhiko Koseki,Shigeo Koyasu,Weon Ju Lee,Andreas Lennartsson,Alan Mackay-Sim,Niklas Mejhert,Yosuke Mizuno,Hiromasa Morikawa,Mitsuru Morimoto,Kazuyo Moro,Kelly J. Morris,Hozumi Motohashi,Christine L. Mummery,Yutaka Nakachi,Yutaka Nakachi,Fumio Nakahara,Toshiyuki Nakamura,Yukio Nakamura,Tadasuke Nozaki,Soichi Ogishima,Naganari Ohkura,Hiroshi Ohno,Mitsuhiro Ohshima,Mariko Okada-Hatakeyama,Yasushi Okazaki,Valerio Orlando,Dmitry A. Ovchinnikov,Robert Passier,Margaret Patrikakis,Ana Pombo,Swati Pradhan-Bhatt,Xian-Yang Qin,Michael Rehli,Patrizia Rizzu,Sugata Roy,Antti Sajantila,Shimon Sakaguchi,Hiroki Sato,Hironori Satoh,Suzana Savvi,Suzana Savvi,Alka Saxena,Christian Schmidl,Claudio Schneider,Gundula Schulze-Tanzil,Anita Schwegmann,Anita Schwegmann,Guojun Sheng,Jay W. Shin,Daisuke Sugiyama,Takaaki Sugiyama,Kim M. Summers,Naoko Takahashi,Jun Takai,Hiroshi Tanaka,Hideki Tatsukawa,Andru Tomoiu,Hiroo Toyoda,Marcvande Wetering,Linda M. van den Berg,Roberto Verardo,Dipti Vijayan,Christine A. Wells,Louise N. Winteringham,Ernst J. Wolvetang,Yoko Yamaguchi,Masayuki Yamamoto,Chiyo Yanagi-Mizuochi,Misako Yoneda,Yohei Yonekura,Peter G. Zhang,Silvia Zucchelli,Imad Abugessaisa,Erik Arner,Jayson Harshbarger,Atsushi Kondo,Timo Lassmann,Marina Lizio,Serkan Sahin,Thierry Sengstag,Jessica Severin,Hisashi Shimoji,Masanori Suzuki,Harukazu Suzuki,Jun Kawai,Naoto Kondo,Masayoshi Itoh,Carsten O. Daub,Takeya Kasukawa,Hideya Kawaji,Piero Carninci,Alistair R. R. Forrest,Yoshihide Hayashizaki +185 more
TL;DR: In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE coupled with single-molecule sequencing to represent the consequence of transcriptional regulation in each analyzed state of mammalian cells.
Journal ArticleDOI
Hereditary frontotemporal dementia is linked to chromosome 17q21—q22: A genetic and clinicopathological study of three dutch families
Peter Heutink,M. Stevens,Patrizia Rizzu,Egbert Bakker,Johan M. Kros,Aad Tibben,Martinus F. Niermeijer,C M van Duijn,Ben A. Oostra,J. C. van Swieten +9 more
TL;DR: Evidence is reported for linkage to chromosome 17q21–q22 with a maximum lod score of 4.70 at Θ = 0.05, suggesting that a group of clinically related neurodegenerative disorders may originate from mutations in the same gene.
Journal ArticleDOI
DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.
Hossein Aleyasin,Maxime W.C. Rousseaux,Paul C. Marcogliese,Sarah Hewitt,Isabella Irrcher,Alvin Joselin,Mohammad Parsanejad,Raymond H. Kim,Patrizia Rizzu,Steve M. Callaghan,Ruth S. Slack,Tak W. Mak,David S. Park +12 more
TL;DR: Evidence is provided that DJ-1 promotes AKT phosphorylation in response to oxidative stress induced by H2O2 in vitro and in vivo following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment, which serves as one explanation for the protective effects ofDJ-1.