S
Sebastian Weis
Researcher at University of Jena
Publications - 87
Citations - 2455
Sebastian Weis is an academic researcher from University of Jena. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 17, co-authored 68 publications receiving 1480 citations. Previous affiliations of Sebastian Weis include Instituto Gulbenkian de Ciência & Stanford University.
Papers
More filters
Journal ArticleDOI
Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress.
Qing Lin,Sebastian Weis,Guang Yang,Yi-Hao Weng,Rachel Helston,Kimberly Rish,Ann Smith,Jessica Bordner,Tobias Polte,Frank Gaunitz,Phyllis A. Dennery,Phyllis A. Dennery +11 more
TL;DR: It is speculated that nuclear localization of HO-1 protein may serve to up-regulate genes that promote cytoprotection against oxidative stress after exposure to hypoxia and heme or heme/hemopexin.
Journal ArticleDOI
The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity.
Marcin F. Osuchowski,Martin Sebastian Winkler,Tomasz Skirecki,Sara Cajander,Manu Shankar-Hari,Manu Shankar-Hari,Gunnar Lachmann,Guillaume Monneret,Fabienne Venet,Michael Bauer,Frank M. Brunkhorst,Sebastian Weis,Alberto García-Salido,Matthijs Kox,Jean-Marc Cavaillon,Florian Uhle,Markus A. Weigand,Stefanie B. Flohé,W. Joost Wiersinga,Raquel Almansa,Amanda de la Fuente,Ignacio Martin-Loeches,Christian Meisel,Thibaud Spinetti,Joerg C. Schefold,Catia Cilloniz,Antoni Torres,Antoni Torres,Evangelos J. Giamarellos-Bourboulis,Ricard Ferrer,Ricard Ferrer,Massimo Girardis,Andrea Cossarizza,Mihai G. Netea,Mihai G. Netea,Mihai G. Netea,Tom van der Poll,Jesus F. Bermejo-Martin,Ignacio Rubio +38 more
TL;DR: The authors reviewed the intricacies of COVID-19 pathophysiology, its various phenotypes, and the anti-SARS-CoV-2 host response at the humoral and cellular levels.
Journal ArticleDOI
Trained immunity, tolerance, priming and differentiation: distinct immunological processes.
Maziar Divangahi,Peter Aaby,Shabaana A. Khader,Luis B. Barreiro,Siroon Bekkering,Triantafyllos Chavakis,Reinout van Crevel,Nigel Curtis,Andrew R. DiNardo,Jorge Domínguez-Andrés,Raphael Duivenwoorden,Raphael Duivenwoorden,Stephanie Fanucchi,Zahi A. Fayad,Elaine Fuchs,Melanie Hamon,Kate L. Jeffrey,Nargis Khan,Leo A. B. Joosten,Eva Kaufmann,Eicke Latz,Giuseppe Matarese,Jos W. M. van der Meer,Musa M. Mhlanga,Simone J.C.F.M. Moorlag,Simone J.C.F.M. Moorlag,Willem J. M. Mulder,Willem J. M. Mulder,Shruti Naik,Boris Novakovic,Luke A. J. O'Neill,Jordi Ochando,Keiko Ozato,Niels P. Riksen,Robert W. Sauerwein,Edward R. Sherwood,Andreas Schlitzer,Andreas Schlitzer,Joachim L. Schultze,Michael H. Sieweke,Michael H. Sieweke,Christine Stabell Benn,Henk Stunnenberg,Joseph C. Sun,Joseph C. Sun,Frank L. van de Veerdonk,Sebastian Weis,David L. Williams,Ramnik J. Xavier,Ramnik J. Xavier,Ramnik J. Xavier,Mihai G. Netea,Mihai G. Netea +52 more
TL;DR: A common framework is established that describes the experimental standards for defining trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects.
Journal ArticleDOI
Metabolic Adaptation Establishes Disease Tolerance to Sepsis
Sebastian Weis,Ana Rita Carlos,Maria Raquel Moita,Sumnima Singh,Birte Blankenhaus,Silvia Cardoso,Rasmus Larsen,Sofia Rebelo,Sascha Schäuble,Laura del Barrio,Gilles Mithieux,Fabienne Rajas,Sandro Lindig,Michael Bauer,Miguel P. Soares +14 more
TL;DR: It is demonstrated that induction of the iron-sequestering ferritin H chain in response to polymicrobial infections is critical to establish disease tolerance to sepsis and a crosstalk between adaptive responses controlling iron and glucose metabolism is required to maintain blood glucose within a physiologic range compatible with host survival.
Journal ArticleDOI
Tissue damage control in disease tolerance.
TL;DR: It is proposed here that tissue damage control underlies many of the protective effects of disease tolerance, and the mechanisms of cellular adaptation that underlie tissueDamage control in response to infection as well as sterile inflammation are explored.