Sebastian Weis

TL;DR: It is speculated that nuclear localization of HO-1 protein may serve to up-regulate genes that promote cytoprotection against oxidative stress after exposure to hypoxia and heme or heme/hemopexin.

TL;DR: The authors reviewed the intricacies of COVID-19 pathophysiology, its various phenotypes, and the anti-SARS-CoV-2 host response at the humoral and cellular levels.

TL;DR: A common framework is established that describes the experimental standards for defining trained immunity in both in vitro and in vivo settings, as well as in experimental models and human subjects.

TL;DR: It is demonstrated that induction of the iron-sequestering ferritin H chain in response to polymicrobial infections is critical to establish disease tolerance to sepsis and a crosstalk between adaptive responses controlling iron and glucose metabolism is required to maintain blood glucose within a physiologic range compatible with host survival.

TL;DR: It is proposed here that tissue damage control underlies many of the protective effects of disease tolerance, and the mechanisms of cellular adaptation that underlie tissueDamage control in response to infection as well as sterile inflammation are explored.