S
Stephen O'Rahilly
Researcher at University of Cambridge
Publications - 537
Citations - 81904
Stephen O'Rahilly is an academic researcher from University of Cambridge. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 138, co-authored 520 publications receiving 75686 citations. Previous affiliations of Stephen O'Rahilly include Dana Corporation & University of Oxford.
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Journal ArticleDOI
Congenital leptin deficiency is associated with severe early-onset obesity in humans
C. T. Montague,I S Farooqi,Jonathan P. Whitehead,Maria A. Soos,Harald Rau,Nicholas J. Wareham,C. P. Sewter,JE Digby,S N Mohammed,J A Hurst,C H Cheetham,A R Earley,Anthony H. Barnett,Johannes B. Prins,Stephen O'Rahilly +14 more
TL;DR: The severe obesity found in two severely obese children who are members of the same highly consanguineous pedigree provides the first genetic evidence that leptin is an important regulator of energy balance in humans.
Journal ArticleDOI
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Elizabeth K. Speliotes,Elizabeth K. Speliotes,Cristen J. Willer,Sonja I. Berndt,Keri L. Monda,Gudmar Thorleifsson,Anne U. Jackson,Hana Lango Allen,Cecilia M. Lindgren,Jian'an Luan,Reedik Maegi,Joshua C. Randall,Sailaja Vedantam,Thomas W. Winkler,Lu Qi,Lu Qi,Tsegaselassie Workalemahu,Iris M. Heid,Valgerdur Steinthorsdottir,Heather M. Stringham,Michael N. Weedon,Eleanor Wheeler,Andrew R. Wood,Teresa Ferreira,Robert J. Weyant,Ayellet V. Segrè,Ayellet V. Segrè,Karol Estrada,Liming Liang,James Nemesh,James Nemesh,Ju-Hyun Park,Stefan Gustafsson,Tuomas O. Kilpelaenen,Jian Yang,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Tõnu Esko,Mary F. Feitosa,Zoltán Kutalik,Massimo Mangino,Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,André Scherag,Albert V. Smith,Ryan P. Welch,Jing Hua Zhao,Katja K.H. Aben,Devin Absher,Najaf Amin,Anna L. Dixon,Eva Fisher,Nicole L. Glazer,Michael E. Goddard,Nancy L. Heard-Costa,Volker Hoesel,Jouke-Jan Hottenga,Åsa Johansson,Åsa Johansson,Toby Johnson,Shamika Ketkar,Claudia Lamina,Shengxu Li,Miriam F. Moffatt,Richard H. Myers,Narisu Narisu,John R. B. Perry,Marjolein Peters,Michael Preuss,Samuli Ripatti,Fernando Rivadeneira,Camilla H. Sandholt,Laura J. Scott,Nicholas J. Timpson,Jonathan Tyrer,Sophie van Wingerden,Richard M. Watanabe,Charles C. White,Fredrik Wiklund,Christina Barlassina,Daniel I. Chasman,Daniel I. Chasman,Mark E. Cooper,John-Olov Jansson,Robert Lawrence,Niina Pellikka,Inga Prokopenko,Jianxin Shi,Elisabeth Thiering,Helene Alavere,Maria Teresa Sciarrone Alibrandi,Peter Almgren,Alice M. Arnold,Thor Aspelund,Larry D. Atwood,Beverley Balkau,Anthony J. Balmforth,Amanda J. Bennett,Yoav Ben-Shlomo,Richard N. Bergman,Sven Bergmann,Heike Biebermann,Alexandra I. F. Blakemore,Tanja Boes,Lori L. Bonnycastle,Stefan R. Bornstein,Morris Brown,Thomas A. Buchanan,Fabio Busonero,Harry Campbell,Francesco P. Cappuccio,Christine Cavalcanti-Proença,Christine Cavalcanti-Proença,Yii-Der Ida Chen,Chih-Mei Chen,Peter S. Chines,Robert Clarke,Lachlan J. M. Coin,John M. C. Connell,Ian N. M. Day,Martin den Heijer,Jubao Duan,Shah Ebrahim,Paul Elliott,Roberto Elosua,Gudny Eiriksdottir,Michael R. Erdos,Johan G. Eriksson,Maurizio F. Facheris,Stephan B. Felix,Pamela Fischer-Posovszky,Aaron R. Folsom,Aaron R. Folsom,Nele Friedrich,Nelson B. Freimer,Mao Fu,Stefan Gaget,Stefan Gaget,Pablo V. Gejman,Eco J. C. de Geus,Christian Gieger,Anette P. Gjesing,Anuj Goel,Philippe Goyette,Harald Grallert,Juergen Graessler,Danielle M. Greenawalt,Christopher J. Groves,Vilmundur Gudnason,Candace Guiducci,Anna-Liisa Hartikainen,Neelam Hassanali,Alistair S. Hall,Aki S. Havulinna,Caroline Hayward,Andrew C. Heath,Christian Hengstenberg,Andrew A. Hicks,Anke Hinney,Albert Hofman,Georg Homuth,Jennie Hui,Wilmar Igl,Carlos Iribarren,Carlos Iribarren,Bo Isomaa,Kevin B. Jacobs,Ivonne Jarick,Elizabeth S. Jewell,Ulrich John,Torben Jørgensen,Pekka Jousilahti,Antti Jula,Marika Kaakinen,Eero Kajantie,Lee M. Kaplan,Sekar Kathiresan,Johannes Kettunen,Leena Kinnunen,Joshua W. Knowles,Ivana Kolcic,Inke R. Koenig,Seppo Koskinen,Peter Kovacs,Johanna Kuusisto,Peter Kraft,Kirsti Kvaløy,Jaana Laitinen,Olivier Lantieri,Chiara Lanzani,Lenore J. Launer,Cécile Lecoeur,Cécile Lecoeur,Terho Lehtimaeki,Guillaume Lettre,Guillaume Lettre,Jianjun Liu,Marja-Liisa Lokki,Mattias Lorentzon,Robert Luben,Barbara Ludwig,Paolo Manunta,Diana Marek,Michel Marre,Nicholas G. Martin,Wendy L. McArdle,Anne McCarthy,Barbara McKnight,Thomas Meitinger,Olle Melander,David Meyre,David Meyre,Kristian Midthjell,Grant W. Montgomery,Mario A. Morken,Andrew P. Morris,Rosanda Mulić,Julius S. Ngwa,Mari Nelis,Mari Nelis,Matt Neville,Dale R. Nyholt,Christopher J. O'Donnell,Stephen O'Rahilly,Ken K. Ong,Ben A. Oostra,Guillaume Paré,Alex N. Parker,Markus Perola,Irene Pichler,Kirsi H. Pietilaeinen,Carl G. P. Platou,Ozren Polasek,Anneli Pouta,Suzanne Rafelt,Olli T. Raitakari,Nigel W. Rayner,Martin Ridderstråle,Winfried Rief,Aimo Ruokonen,Neil Robertson,Peter Rzehak,Veikko Salomaa,Alan R. Sanders,Manjinder S. Sandhu,Manjinder S. Sandhu,Serena Sanna,Jouko Saramies,Markku J. Savolainen,Susann Scherag,Sabine Schipf,Stefan Schreiber,Heribert Schunkert,Kaisa Silander,Juha Sinisalo,David S. Siscovick,Jan Smit,Nicole Soranzo,Nicole Soranzo,Ulla Sovio,Jonathan Stephens,Jonathan Stephens,Ida Surakka,Amy J. Swift,Mari-Liis Tammesoo,Jean-Claude Tardif,Jean-Claude Tardif,Maris Teder-Laving,Tanya M. Teslovich,John R. Thompson,John R. Thompson,Brian Thomson,Anke Toenjes,Tiinamaija Tuomi,Joyce B. J. van Meurs,Gert-Jan B. van Ommen,Vincent Vatin,Vincent Vatin,Jorma S. A. Viikari,Jorma S. A. Viikari,Sophie Visvikis-Siest,Veronique Vitart,Carla I. G. Vogel,Benjamin F. Voight,Lindsay L. Waite,Henri Wallaschofski,G. Bragi Walters,Elisabeth Widen,Susanna Wiegand,Sarah H. Wild,Gonneke Willemsen,Daniel R. Witte,Jacqueline C. M. Witteman,Jianfeng Xu,Qunyuan Zhang,Lina Zgaga,Andreas Ziegler,Paavo Zitting,John Beilby,I. Sadaf Farooqi,Johannes Hebebrand,Heikki V. Huikuri,Alan James,Mika Kaehoenen,Douglas F. Levinson,Fabio Macciardi,Fabio Macciardi,Markku S. Nieminen,Claes Ohlsson,Lyle J. Palmer,Paul M. Ridker,Paul M. Ridker,Michael Stumvoll,Jacques S. Beckmann,Heiner Boeing,Eric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Stephen J. Chanock,Francis S. Collins,L. Adrienne Cupples,George Davey Smith,Jeanette Erdmann,Philippe Froguel,Philippe Froguel,Philippe Froguel,Henrik Greonberg,Ulf Gyllensten,Per Hall,Torben Hansen,Tamara B. Harris,Andrew T. Hattersley,Richard B. Hayes,Joachim Heinrich,Frank B. Hu,Frank B. Hu,Kristian Hveem,Thomas Illig,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Jaakko Kaprio,Fredrik Karpe,Kay-Tee Khaw,Lambertus A. Kiemeney,Heiko Krude,Markku Laakso,Debbie A Lawlor,Andres Metspalu,Patricia B. Munroe,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Oluf Pedersen,Oluf Pedersen,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Annette Peters,Peter P. Pramstaller,Thomas Quertermous,Thomas Reinehr,Aila Rissanen,Igor Rudan,Igor Rudan,Nilesh J. Samani,Peter Schwarz,Alan R. Shuldiner,Tim D. Spector,Jaakko Tuomilehto,Manuela Uda,André G. Uitterlinden,Timo T. Valle,Martin Wabitsch,Gerard Waeber,Nicholas J. Wareham,Hugh Watkins,James F. Wilson,Alan F. Wright,M. Carola Zillikens,Nilanjan Chatterjee,Steven A. McCarroll,Shaun Purcell,Eric E. Schadt,Peter M. Visscher,Themistocles L. Assimes,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Leif Groop,Talin Haritunians,David J. Hunter,David J. Hunter,Robert C. Kaplan,Karen L. Mohlke,Jeffrey R. O'Connell,Leena Peltonen,David Schlessinger,David P. Strachan,Cornelia M. van Duijn,H-Erich Wichmann,Timothy M. Frayling,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Gonçalo R. Abecasis,Inês Barroso,Inês Barroso,Michael Boehnke,Kari Stefansson,Kari Stefansson,Kari E. North,Mark I. McCarthy,Joel N. Hirschhorn,Erik Ingelsson,Ruth J. F. Loos +413 more
TL;DR: Genetic loci associated with body mass index map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor, which may provide new insights into human body weight regulation.
Journal ArticleDOI
The GPR54 gene as a regulator of puberty
Stephanie B. Seminara,Sophie Messager,Emmanouella E. Chatzidaki,Rosemary R. Thresher,James S. Acierno,Jenna K. Shagoury,Yousef Bo-Abbas,Wendy Kuohung,Kristine M. Schwinof,Alan G. Hendrick,Dirk Zahn,John Dixon,Ursula B. Kaiser,Susan A. Slaugenhaupt,James F. Gusella,Stephen O'Rahilly,Mark Carlton,William F. Crowley,Samuel Aparicio,William H. Colledge +19 more
TL;DR: Puberty is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus, and complementary genetic approaches in humans and mice identified genetic factors that determine the onset of puberty.
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Elizabeth K. Speliotes,Cristen J. Willer,Sonja I. Berndt,Keri L. Monda,Gudmar Thorleifsson,Anne U. Jackson,H Lango Allen,Cecilia M. Lindgren,Jian'an Luan,Reedik Mägi,Joshua C. Randall,Sailaja Vedantam,Thomas W. Winkler,Lu Qi,Tsegaselassie Workalemahu,Iris M. Heid,Valgerdur Steinthorsdottir,Heather M. Stringham,Michael N. Weedon,Eleanor Wheeler,Andrew R. Wood,Teresa Ferreira,Robert J. Weyant,Ayellet V. Segrè,K. Estrada,Liming Liang,James Nemesh,Ju-Hyun Park,Stefan Gustafsson,Tuomas O. Kilpeläinen,Jian Yang,Nabila Bouatia-Naji,Tõnu Esko,Mary F. Feitosa,Zoltán Kutalik,Massimo Mangino,Soumya Raychaudhuri,André Scherag,Albert V. Smith,Ryan P. Welch,Jing Hua Zhao,Katja K.H. Aben,Devin Absher,Najaf Amin,Anna L. Dixon,Eva Fisher,Nicole L. Glazer,Michael E. Goddard,Nancy L. Heard-Costa,Volker Hoesel,Jouke-Jan Hottenga,Åsa Johansson,Toby Johnson,Shamika Ketkar,Claudia Lamina,Shengxu Li,MF Moffatt,Richard H. Myers,Narisu Narisu,John R. B. Perry,Maire Peters,Michael Preuss,Samuli Ripatti,Fernando Rivadeneira,Camilla H. Sandholt,Laura J. Scott,Nicholas J. Timpson,Jonathan Tyrer,S. van Wingerden,Richard M. Watanabe,Charles L. White,Fredrik Wiklund,Cristina Barlassina,Daniel I. Chasman,Mark E. Cooper,John-Olov Jansson,Robert W. Lawrence,Niina Pellikka,Inga Prokopenko,Jianxin Shi,Elisabeth Thiering,Helene Alavere,Maria Teresa Sciarrone Alibrandi,Peter Almgren,Andreas Arnold,Thor Aspelund,Larry D. Atwood,Beverley Balkau,Anthony J. Balmforth,Amanda J. Bennett,Yoav Ben-Shlomo,Richard N. Bergman,Sven Bergmann,Heike Biebermann,Alexandra I. F. Blakemore,Tanja Boes,Lori L. Bonnycastle,Stefan R. Bornstein,Michael Brown,Thomas A. Buchanan,Fabio Busonero,Harry Campbell,Francesco P. Cappuccio,Christine Cavalcanti-Proença,Y. D. Chen,C. M. Chen,Peter S. Chines,Robert Clarke,Lachlan J. M. Coin,John M. C. Connell,Ian N.M. Day,M. den Heijer,Jubao Duan,Shah Ebrahim,Paul Elliott,Roberto Elosua,G. Eiriksdottir,Mike Erdos,Johan G. Eriksson,Maurizio Facheris,Stephan B. Felix,Pamela Fischer-Posovszky,Aaron R. Folsom,Nele Friedrich,Nelson B. Freimer,Mao Fu,Stéphane Gaget,Pablo V. Gejman,Eco J. C. de Geus,Christian Gieger,Anette P. Gjesing,Anuj Goel,Philippe Goyette,Harald Grallert,Jürgen Grässler,Danielle M. Greenawalt,C J Groves,Vilmundur Gudnason,Candace Guiducci,A.-L. Hartikainen,N Hassanali,Alistair S. Hall,Aki S. Havulinna,Caroline Hayward,Andrew C. Heath,Christian Hengstenberg,Andrew A. Hicks,Anke Hinney,Albert Hofman,G. Homuth,Jennie Hui,Wilmar Igl,Carlos Iribarren,Bo Isomaa,Kevin B. Jacobs,Ivonne Jarick,Elizabeth S. Jewell,Ulrich John,Torben Jørgensen,P. Jousilahti,A. Jula,Marika Kaakinen,Eero Kajantie,Lee M. Kaplan,Sekar Kathiresan,Johannes Kettunen,Leena Kinnunen,Joshua W. Knowles,Ivana Kolcic,Inke R. König,Seppo Koskinen,Peter Kovacs,Johanna Kuusisto,Peter Kraft,Kirsti Kvaløy,Jaana Laitinen,Olivier Lantieri,Chiara Lanzani,Lenore J. Launer,Cécile Lecoeur,Terho Lehtimäki,Guillaume Lettre,Jianjun Liu,Marja-Liisa Lokki,Mattias Lorentzon,Robert Luben,Barbara Ludwig,Paolo Manunta,Diana Marek,Michel Marre,Nicholas G. Martin,Wendy L. McArdle,Alun D. McCarthy,Barbara McKnight,Thomas Meitinger,Olle Melander,David Meyre,Kristian Midthjell,Grant W. Montgomery,M. A. Morken,Andrew P. Morris,Rosanda Mulić,Julius S. Ngwa,Mari Nelis,Matt Neville,Dale R. Nyholt,Christopher J. O'Donnell,Stephen O'Rahilly,Ken K. Ong,Ben A. Oostra,Guillaume Paré,Alex N. Parker,Markus Perola,Irene Pichler,Kirsi H. Pietiläinen,Carl Platou,Ozren Polasek,A Pouta,Suzanne Rafelt,Olli T. Raitakari,Nigel W. Rayner,Martin Ridderstråle,Winfried Rief,Aimo Ruokonen,Neil R. Robertson,Peter Rzehak,Veikko Salomaa,Alan R. Sanders,Manjinder S. Sandhu,Serena Sanna,Jouko Saramies,Markku J. Savolainen,S. Scherag,Sabine Schipf,Stefan Schreiber,Heribert Schunkert,Kaisa Silander,Juha Sinisalo,David S. Siscovick,J.H. Smit,Nicole Soranzo,Ulla Sovio,J. Stephens,Ida Surakka,Amy J. Swift,M. L. Tammesoo,Jean-Claude Tardif,Maris Teder-Laving,Tanya M. Teslovich,John R. Thompson,Brian Thomson,A Tönjes,Tiinamaija Tuomi,J.B. van Meurs,G.J.B. van Ommen,Vincent Vatin,Jorma Viikari,Sophie Visvikis-Siest,Veronique Vitart,Charlotte Vogel,Benjamin F. Voight,Lindsay L. Waite,Henri Wallaschofski,G B Walters,E. Widen,Susanna Wiegand,Sarah H. Wild,Gonneke Willemsen,Daniel R. Witte,Jacqueline C. M. Witteman,Jianfeng Xu,Qunyuan Zhang,Lina Zgaga,Andreas Ziegler,P. Zitting,John Beilby,I S Farooqi,Johannes Hebebrand,Heikki V. Huikuri,Alan L. James,Mika Kähönen,Douglas F. Levinson,Fabio Macciardi,Markku S. Nieminen,Claes Ohlsson,Lyle J. Palmer,Paul M. Ridker,Michael Stumvoll,Jacques S. Beckmann,H. Boeing,Eric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Stephen J. Chanock,Francis S. Collins,L. A. Cupples,George Davey Smith,Jeanette Erdmann,Philippe Froguel,Henrik Grönberg,Ulf Gyllensten,Per Hall,Torben Hansen,Tamara B. Harris,Andrew T. Hattersley,Richard B. Hayes,Joachim Heinrich,Frank B. Hu,Kristian Hveem,Thomas Illig,Marjo-Riitta Järvelin,Jaakko Kaprio,Fredrik Karpe,Kay-Tee Khaw,Lambertus A. Kiemeney,Heiko Krude,Markku Laakso,Debbie A Lawlor,Andres Metspalu,Patricia B. Munroe,Willem H. Ouwehand,Oluf Pedersen,Brenda W.J.H. Penninx,Annette Peters,Peter P. Pramstaller,Thomas Quertermous,Thomas Reinehr,A. Rissanen,Igor Rudan,Nilesh J. Samani,Peter Schwarz,Alan R. Shuldiner,Tim D. Spector,Jaakko Tuomilehto,Manuela Uda,André G. Uitterlinden,Valle Tt,Martin Wabitsch,G. Waeber,Nicholas J. Wareham,Hugh Watkins,James F. Wilson,Alan F. Wright,M. C. Zillikens,Nilanjan Chatterjee,Steven A. McCarroll,Shaun Purcell,Eric E. Schadt,Peter M. Visscher,Themistocles L. Assimes,Ingrid B. Borecki,Panos Deloukas,Caroline S. Fox,Leif Groop,Talin Haritunians,David J. Hunter,Robert C. Kaplan,Karen L. Mohlke,Jeffrey R. O'Connell,Leena Peltonen,David Schlessinger,David P. Strachan,C M van Duijn,H. E. Wichmann,Timothy M. Frayling,Unnur Thorsteinsdottir,Gonçalo R. Abecasis,Inês Barroso,Michael Boehnke,Kari Stefansson,Kari E. North,Mark I. McCarthy,Joel N. Hirschhorn,Erik Ingelsson,Ruth J. F. Loos +374 more
TL;DR: 18 new loci associated with body mass index are identified, one of which includes a copy number variant near GPRC5B, and genes in other newly associated loci may provide new insights into human body weight regulation.
Journal ArticleDOI
Effects of recombinant leptin therapy in a child with congenital leptin deficiency.
I S Farooqi,Susan A. Jebb,G Langmack,Elizabeth Lawrence,C H Cheetham,Andrew M. Prentice,Ieuan A. Hughes,M A McCamish,Stephen O'Rahilly +8 more
TL;DR: The administration of leptin corrects their obesity by reducing their food intake and increasing their energy expenditure and these mice also have hyperinsulinemia, corticosterone excess, and infertility, which also are reversed by treatment with leptin.