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Showing papers by "DSM published in 2013"


Journal ArticleDOI
TL;DR: In this paper, the authors presented a large-scale spatial resolution map of the CO-to-H$2}$ conversion factor and dust-togas ratio (DGR) in 26 nearby, star-forming galaxies.
Abstract: We present ~{}kiloparsec spatial resolution maps of the CO-to-H$_{2}$ conversion factor ({$α$}$_{CO}$) and dust-to-gas ratio (DGR) in 26 nearby, star-forming galaxies. We have simultaneously solved for {$α$}$_{CO}$ and the DGR by assuming that the DGR is approximately constant on kiloparsec scales. With this assumption, we can combine maps of dust mass surface density, CO-integrated intensity, and H I column density to solve for both {$α$}$_{CO}$ and the DGR with no assumptions about their value or dependence on metallicity or other parameters. Such a study has just become possible with the availability of high-resolution far-IR maps from the Herschel key program KINGFISH, $^{12}$CO J = (2-1) maps from the IRAM 30 m large program HERACLES, and H I 21 cm line maps from THINGS. We use a fixed ratio between the (2-1) and (1-0) lines to present our {$α$}$_{CO}$ results on the more typically used $^{12}$CO J = (1-0) scale and show using literature measurements that variations in the line ratio do not affect our results. In total, we derive 782 individual solutions for {$α$}$_{CO}$ and the DGR. On average, {$α$}$_{CO}$ = 3.1 M $_{☉}$ pc$^{–2}$ (K km s$^{–1}$)$^{–1}$ for our sample with a standard deviation of 0.3 dex. Within galaxies, we observe a generally flat profile of {$α$}$_{CO}$ as a function of galactocentric radius. However, most galaxies exhibit a lower {$α$}$_{CO}$ value in the central kiloparsec{mdash}a factor of ~{}2 below the galaxy mean, on average. In some cases, the central {$α$}$_{CO}$ value can be factors of 5-10 below the standard Milky Way (MW) value of {$α$}$_{CO, MW}$ = 4.4 M $_{☉}$ pc$^{–2}$ (K km s$^{–1}$)$^{–1}$. While for {$α$}$_{CO}$ we find only weak correlations with metallicity, the DGR is well-correlated with metallicity, with an approximately linear slope. Finally, we present several recommendations for choosing an appropriate {$α$}$_{CO}$ for studies of nearby galaxies.

533 citations


Journal ArticleDOI
TL;DR: A better understanding of OSA's hydrophobic and steric contribution and starch's peculiar highly branched macromolecular structure has the potential to lead to products with targeted macromolescular structures and optimized properties for specific applications.

482 citations


Journal ArticleDOI
TL;DR: In this article, it was shown that it is possible to form a prominent dark matter core within the well-controlled framework of an isolated, initially cuspy, 10 billion solar masses dark matter halo.
Abstract: The presence of a dark matter core in the central kiloparsec of many dwarf galaxies has been a long standing problem in galaxy formation theories based on the standard cold dark matter paradigm. Recent simulations, based on Smooth Particle Hydrodynamics and rather strong feedback recipes have shown that it was indeed possible to form extended dark matter cores using baryonic processes related to a more realistic treatment of the interstellar medium. Using adaptive mesh renement, together with a new, stronger supernovae feedback scheme that we have recently implemented in the RAMSES code, we show that it is also possible to form a prominent dark matter core within the well-controlled framework of an isolated, initially cuspy, 10 billion solar masses dark matter halo. Although our numerical experiment is idealized, it allows a clean and unambiguous identication of the dark matter core formation process. Our dark matter inner prole is well tted by a pseudo-isothermal prole with a core radius of 800 pc. The core formation mechanism is consistent with the one proposed recently by Pontzen & Governato. We highlight two key observational predictions of all simulations that nd cusp-core transformations: (i) a bursty star formation history (SFH) with peak to trough ratio of 5 to 10 and a duty cycle comparable to the local dynamical time; and (ii) a stellar distribution that is hot with v= 1. We compare the observational properties of our model galaxy with recent measurements of the isolated dwarf WLM. We show that the spatial and kinematical distribution of stars and HI gas are in striking agreement with observations, supporting the fundamental role played by stellar feedback in shaping both the stellar and dark matter distribution.

423 citations


Journal ArticleDOI
12 Jun 2013-PLOS ONE
TL;DR: The current indices and maps provide crucial data to optimize the prioritization of program assistance addressing global multiple micronutrient deficiencies, and serve as a useful advocacy tool in the call for increased commitments to scale up effective nutrition interventions.
Abstract: The unified global efforts to mitigate the high burden of vitamin and mineral deficiency, known as hidden hunger, in populations around the world are crucial to the achievement of most of the Millennium Development Goals (MDGs). We developed indices and maps of global hidden hunger to help prioritize program assistance, and to serve as an evidence-based global advocacy tool. Two types of hidden hunger indices and maps were created based on i) national prevalence data on stunting, anemia due to iron deficiency, and low serum retinol levels among preschool-aged children in 149 countries; and ii) estimates of Disability Adjusted Life Years (DALYs) attributed to micronutrient deficiencies in 136 countries. A number of countries in sub-Saharan Africa, as well as India and Afghanistan, had an alarmingly high level of hidden hunger, with stunting, iron deficiency anemia, and vitamin A deficiency all being highly prevalent. The total DALY rates per 100,000 population, attributed to micronutrient deficiencies, were generally the highest in sub-Saharan African countries. In 36 countries, home to 90% of the world’s stunted children, deficiencies of micronutrients were responsible for 1.5-12% of the total DALYs. The pattern and magnitude of iodine deficiency did not conform to that of other micronutrients. The greatest proportions of children with iodine deficiency were in the Eastern Mediterranean (46.6%), European (44.2%), and African (40.4%) regions. The current indices and maps provide crucial data to optimize the prioritization of program assistance addressing global multiple micronutrient deficiencies. Moreover, the indices and maps serve as a useful advocacy tool in the call for increased commitments to scale up effective nutrition interventions.

370 citations


Journal ArticleDOI
Peter A. R. Ade1, Nabila Aghanim2, M. I. R. Alves2, C. Armitage-Caplan3  +467 moreInstitutions (88)
TL;DR: The ESA's Planck satellite was launched 14 May 2009 and has been scanning the microwave and sub-millimetre sky continuously since 12 August 2009 as discussed by the authors, where it has measured gravitational lensing of CMB anisotropies at greater than 25 sigma.
Abstract: The ESA's Planck satellite, dedicated to studying the early Universe and its subsequent evolution, was launched 14 May 2009 and has been scanning the microwave and submillimetre sky continuously since 12 August 2009. This paper gives an overview of the mission and its performance, the processing, analysis, and characteristics of the data, the scientific results, and the science data products and papers in the release. The science products include maps of the CMB and diffuse extragalactic foregrounds, a catalogue of compact Galactic and extragalactic sources, and a list of sources detected through the SZ effect. The likelihood code used to assess cosmological models against the Planck data and a lensing likelihood are described. Scientific results include robust support for the standard six-parameter LCDM model of cosmology and improved measurements of its parameters, including a highly significant deviation from scale invariance of the primordial power spectrum. The Planck values for these parameters and others derived from them are significantly different from those previously determined. Several large-scale anomalies in the temperature distribution of the CMB, first detected by WMAP, are confirmed with higher confidence. Planck sets new limits on the number and mass of neutrinos, and has measured gravitational lensing of CMB anisotropies at greater than 25 sigma. Planck finds no evidence for non-Gaussianity in the CMB. Planck's results agree well with results from the measurements of baryon acoustic oscillations. Planck finds a lower Hubble constant than found in some more local measures. Some tension is also present between the amplitude of matter fluctuations derived from CMB data and that derived from SZ data. The Planck and WMAP power spectra are offset from each other by an average level of about 2% around the first acoustic peak.

367 citations


Journal ArticleDOI
A. Abramowski1, Fabio Acero2, Felix Aharonian3, Felix Aharonian4  +207 moreInstitutions (28)
TL;DR: In this article, the authors measured the imprint of the EBL opacity to gamma-rays on the spectra of the brightest extragalactic sources detected with the High Energy Stereoscopic System (H.E.S.).
Abstract: The extragalactic background light (EBL) is the diffuse radiation with the second highest energy density in the Universe after the cosmic microwave background. The aim of this study is the measurement of the imprint of the EBL opacity to gamma-rays on the spectra of the brightest extragalactic sources detected with the High Energy Stereoscopic System (H.E.S.S.). The originality of the method lies in the joint fit of the EBL optical depth and of the intrinsic spectra of the sources, assuming intrinsic smoothness. Analysis of a total of ~10^5 gamma-ray events enables the detection of an EBL signature at the 8.8 std dev level and constitutes the first measurement of the EBL optical depth using very-high energy (E>100 GeV) gamma-rays. The EBL flux density is constrained over almost two decades of wavelengths (0.30-17 microns) and the peak value at 1.4 micron is derived as 15 +/- 2 (stat) +/- 3 (sys) nW / m^2 sr.

252 citations


Journal ArticleDOI
TL;DR: In this article, Monte Carlo simulations are used to optimize the Cherenkov Telescopes Array (CTA) design and layout for very high-energy (VHE) gamma-ray astronomy.

243 citations


Journal ArticleDOI
09 May 2013-Nature
TL;DR: ElectricOctupole transition strengths are determined (a direct measure of octupole correlations) for short-lived isotopes of radon and radium to constrain suitable candidates for experimental studies of atomic electric-dipole moments that might reveal extensions to the standard model.
Abstract: There is strong circumstantial evidence that certain heavy, unstable atomic nuclei are ‘octupole deformed’, that is, distorted into a pear shape. This contrasts with the more prevalent rugby-ball shape of nuclei with reflection-symmetric, quadrupole deformations. The elusive octupole deformed nuclei are of importance for nuclear structure theory, and also in searches for physics beyond the standard model; any measurable electric-dipole moment (a signature of the latter) is expected to be amplified in such nuclei. Here we determine electric octupole transition strengths (a direct measure of octupole correlations) for short-lived isotopes of radon and radium. Coulomb excitation experiments were performed using accelerated beams of heavy, radioactive ions. Our data on 220Rn and 224Ra show clear evidence for stronger octupole deformation in the latter. The results enable discrimination between differing theoretical approaches to octupole correlations, and help to constrain suitable candidates for experimental studies of atomic electric-dipole moments that might reveal extensions to the standard model. An experimental study of certain short-lived isotopes of radon and radium has found clear octupole deformation in the nuclei of the latter — that is, these nuclei are pear-shaped; the results enable discrimination between differing theoretical approaches to octupole correlations. The atomic nucleus is a many-body quantum system with a shape determined by the number of nucleons that it contains and the interactions between them. Most of the several thousand known stable and radioactive atomic nuclei, with differing numbers of protons and neutrons, are spherical or rugby-ball shaped. But there is circumstantial evidence that some heavy, unstable nuclides are distorted into a pear shape through the phenomenon of octupole deformation. Samples of these rare atomic species can be accelerated to 8% of the speed of light in the REX-ISOLDE facility at CERN, and now Coulomb excitation experiments on beams of the short-lived isotopes radium-224 and radon-220 have demonstrated clear octupole deformation in the former. The results make it possible to discriminate between the various theoretical models of octupole-deformed nuclei, and are also relevant to the pursuit of physics beyond the Standard Model.

239 citations


Journal ArticleDOI
TL;DR: It is concluded that further investigations are needed to establish how differences among the vitamin K forms may influence tissue specificities and their role in human health, and there is merit for considering both menaquinones and phylloquinone when developing future recommendations for vitamin K intake.
Abstract: Recent reports have attributed the potential health benefits of vitamin K beyond its function to activate hepatic coagulation factors. Moreover, several studies have suggested that menaquinones, also known as vitamin K2, may be more effective in activating extra-hepatic vitamin K-dependent proteins than phylloquinone, also known as vitamin K1. Nevertheless, present dietary reference values (DRV) for vitamin K are exclusively based on phylloquinone, and its function in coagulation. The present review describes the current knowledge on menaquinones based on the following criteria for setting DRV: optimal dietary intake; nutrient amount required to prevent deficiency, maintain optimal body stores and/or prevent chronic disease; factors influencing requirements such as absorption, metabolism, age and sex. Dietary intake of menaquinones accounts for up to 25% of total vitamin K intake and contributes to the biological functions of vitamin K. However, menaquinones are different from phylloquinone with respect to their chemical structure and pharmacokinetics, which affects bioavailability, metabolism and perhaps impact on health outcomes. There are significant gaps in the current knowledge on menaquinones based on the criteria for setting DRV. Therefore, we conclude that further investigations are needed to establish how differences among the vitamin K forms may influence tissue specificities and their role in human health. However, there is merit for considering both menaquinones and phylloquinone when developing future recommendations for vitamin K intake.

232 citations


Journal ArticleDOI
TL;DR: The Planck Sky Model (PSM) as mentioned in this paper is a parametric model for the generation of all-sky, few arcminute resolution maps of sky emission at submillimetre to centimetre wavelengths, in both intensity and polarisation.
Abstract: We present the Planck Sky Model (PSM), a parametric model for the generation of all-sky, few arcminute resolution maps of sky emission at submillimetre to centimetre wavelengths, in both intensity and polarisation. Several options are implemented to model the cosmic microwave background, Galactic diffuse emission (synchrotron, free-free, thermal and spinning dust, CO lines), Galactic H-II regions, extragalactic radio sources, dusty galaxies, and thermal and kinetic Sunyaev-Zeldovich signals from clusters of galaxies. Each component is simulated by means of educated interpolations/extrapolations of data sets available at the time of the launch of the Planck mission, complemented by state-of-the-art models of the emission. Distinctive features of the simulations are: spatially varying spectral properties of synchrotron and dust; different spectral parameters for each point source; modeling of the clustering properties of extragalactic sources and of the power spectrum of fluctuations in the cosmic infrared background. The PSM enables the production of random realizations of the sky emission, constrained to match observational data within their uncertainties, and is implemented in a software package that is regularly updated with incoming information from observations. The model is expected to serve as a useful tool for optimizing planned microwave and sub-millimetre surveys and to test data processing and analysis pipelines. It is, in particular, used for the development and validation of data analysis pipelines within the planck collaboration. A version of the software that can be used for simulating the observations for a variety of experiments is made available on a dedicated website.

231 citations


Journal ArticleDOI
TL;DR: Serum lutein, zeaxanthin, and β-carotene concentrations were most consistently related to better cognition in the whole population and in the centenarians, and the status of certain carotenoids in the old may reflect their cognitive function.
Abstract: Oxidative stress is involved in age-related cognitive decline. The dietary antioxidants, carotenoids, tocopherols, and vitamin A may play a role in the prevention or delay in cognitive decline. In this study, sera were obtained from 78 octogenarians and 220 centenarians from the Georgia Centenarian Study. Brain tissues were obtained from 47 centenarian decedents. Samples were analyzed for carotenoids, α-tocopherol, and retinol using HPLC. Analyte concentrations were compared with cognitive tests designed to evaluate global cognition, dementia, depression and cognitive domains (memory, processing speed, attention, and executive functioning). Serum lutein, zeaxanthin, and β-carotene concentrations were most consistently related to better cognition (P < 0.05) in the whole population and in the centenarians. Only serum lutein was significantly related to better cognition in the octogenarians. In brain, lutein and β-carotene were related to cognition with lutein being consistently associated with a range of measures. There were fewer significant relationships for α-tocopherol and a negative relationship between brain retinol concentrations and delayed recognition. These findings suggest that the status of certain carotenoids in the old may reflect their cognitive function. The protective effect may not be related to an antioxidant effect given that α-tocopherol was less related to cognition than these carotenoids.

Journal ArticleDOI
Halina Abramowicz1, I. Abt2, Leszek Adamczyk3, M. Adamus  +486 moreInstitutions (62)
TL;DR: In this article, the effect of different heavy flavour schemes on the parton distribution functions was investigated. And the running mass of the charm quark was determined using the fixed flavour number scheme.
Abstract: Measurements of open charm production cross sections in deep-inelastic ep scattering at HERA from the H1 and ZEUS Collaborations are combined. Reduced cross sections \(\sigma_{\rm red}^{c\bar{c}}\) for charm production are obtained in the kinematic range of photon virtuality 2.5≤Q2≤2000 GeV2 and Bjorken scaling variable 3⋅10−5≤x≤5⋅10−2. The combination method accounts for the correlations of the systematic uncertainties among the different data sets. The combined charm data together with the combined inclusive deep-inelastic scattering cross sections from HERA are used as input for a detailed NLO QCD analysis to study the influence of different heavy flavour schemes on the parton distribution functions. The optimal values of the charm mass as a parameter in these different schemes are obtained. The implications on the NLO predictions for W± and Z production cross sections at the LHC are investigated. Using the fixed flavour number scheme, the running mass of the charm quark is determined.

Journal ArticleDOI
TL;DR: In this article, the authors report on their observations of the 79 and 119µm doublet transitions of OH for 24 local ULIRGs observed with Herschel-PACS as part of the Herschel ULIRG Survey (HERUS).
Abstract: We report on our observations of the 79 and 119µm doublet transitions of OH for 24 local (z<0.262) ULIRGs observed with Herschel-PACS as part of the Herschel ULIRG Survey (HERUS). Some OH119 profiles display a clear P-Cygni shape and therefore imply outflowing OH gas, other profiles are predominantly in absorption or are completely in emission. We find that the relative strength of the OH emission component decreases as the silicate absorption increases. This locates the OH outflows inside the obscured nuclei. The maximum outflow velocities for our sources range from less than 100 to �2000km s −1 , with 15/24 (10/24) sources showing OH absorption at velocities exceeding 700km s −1 (1000km s −1 ). Three sources show maximum OH outflow velocities exceeding that of Mrk231. Since outflow velocities above 500–700km s −1 are thought to require an active galactic nucleus (AGN) to drive them, about 2/3 of our ULIRG sample may host AGN-driven molecular outflows. This finding is supported by the correlation we find between the maximum OH outflow velocity and the IR-derived bolometric AGN luminosity. No such correlation is found with the IR-derived star formation rate. The highest outflow velocities are found among sources which are still deeply embedded. We speculate that the molecular outflows in these sources may be in an early phase of disrupting the nuclear dust veil before these sources evolve into less obscured AGN. Four of our sources show high-velocity wings in their [C II] fine-structure line profiles implying neutral gas outflow masses of at least 2–4.5×10 8 M⊙. Subject headings: infrared: galaxies – galaxies: ISM – quasars: absorption lines – galaxies: evolution – ISM: jets and outflows

Journal ArticleDOI
TL;DR: In this article, Herschel observations of 6 fine-structure lines in 25 ultraluminous infrared galaxies at z < 0.27 were used to derive relations between far-IR line luminosities and both the IR luminosity and star formation rate.
Abstract: We present Herschel observations of 6 fine-structure lines in 25 ultraluminous infrared galaxies at z < 0.27. The lines, [O III]52 μm, [N III]57 μm, [O I]63 μm, [N II]122 μm, [O I]145 μm, and [C II]158 μm, are mostly single Gaussians with widths <600 km s^(–1) and luminosities of 10^7-10^9 L_☉. There are deficits in the [O I]63/L_(IR), [N II]/L_(IR), [O I]145/L_(IR), and [C II]/L_(IR) ratios compared to lower luminosity systems. The majority of the line deficits are consistent with dustier H II regions, but part of the [C II] deficit may arise from an additional mechanism, plausibly charged dust grains. This is consistent with some of the [C II] originating from photodissociation regions or the interstellar medium (ISM). We derive relations between far-IR line luminosities and both the IR luminosity and star formation rate. We find that [N II] and both [O I] lines are good tracers of the IR luminosity and star formation rate. In contrast, [C II] is a poor tracer of the IR luminosity and star formation rate, and does not improve as a tracer of either quantity if the [C II] deficit is accounted for. The continuum luminosity densities also correlate with the IR luminosity and star formation rate. We derive ranges for the gas density and ultraviolet radiation intensity of 10^1 < n < 10^(2.5) and 10^(2.2) < G_0 < 10^(3.6), respectively. These ranges depend on optical type, the importance of star formation, and merger stage. We do not find relationships between far-IR line properties and several other parameters: active galactic nucleus (AGN) activity, merger stage, mid-IR excitation, and SMBH mass. We conclude that these far-IR lines arise from gas heated by starlight, and that they are not strongly influenced by AGN activity.

Journal ArticleDOI
Peter A. R. Ade1, Nabila Aghanim2, Monique Arnaud3, M. Ashdown4  +249 moreInstitutions (61)
TL;DR: In this article, the scaling relation between Sunyaev-Zeldovich (SZ) signal and stellar mass for almost 260,000 locally brightest galaxies (LBGs) selected from the Sloan Digital Sky Survey (SDSS) was presented.
Abstract: We present the scaling relation between Sunyaev-Zeldovich (SZ) signal and stellar mass for almost 260,000 locally brightest galaxies (LBGs) selected from the Sloan Digital Sky Survey (SDSS). These are predominantly the central galaxies of their dark matter halos. We calibrate the stellar-to-halo mass conversion using realistic mock catalogues based on the Millennium Simulation. Applying a multi-frequency matched filter to the Planck data for each LBG, and averaging the results in bins of stellar mass, we measure the mean SZ signal down to M-* similar to 2 x 10(11) M-circle dot, with a clear indication of signal at even lower stellar mass. We derive the scaling relation between SZ signal and halo mass by assigning halo properties from our mock catalogues to the real LBGs and simulating the Planck observation process. This relation shows no evidence for deviation from a power law over a halo mass range extending from rich clusters down to M-500 similar to 2 x 10(13) M-circle dot, and there is a clear indication of signal down to M-500 similar to 4 x 10(12) M-circle dot. Planck's SZ detections in such low-mass halos imply that about a quarter of all baryons have now been seen in the form of hot halo gas, and that this gas must be less concentrated than the dark matter in such halos in order to remain consistent with X-ray observations. At the high-mass end, the measured SZ signal is 20 % lower than found from observations of X-ray clusters, a difference consistent with the magnitude of Malmquist bias effects that were previously estimated for the X-ray sample.

Journal ArticleDOI
S. Chatrchyan1, Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1  +2192 moreInstitutions (139)
TL;DR: In this paper, a measurement of the inelastic proton-proton cross section at a center-of-mass energy of 7 TeV was presented using the CMS detector at the LHC.

Journal ArticleDOI
S. Chatrchyan1, Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1  +3864 moreInstitutions (145)
TL;DR: Normalised differential top-quark pair production cross sections are measured in pp collisions at a centre-of-mass energy of 7 TeV at the LHC with the CMS detector using data recorded in 2011 corresponding to an integrated luminosity of 5.0 inverse femtobarns as discussed by the authors.
Abstract: Normalised differential top-quark pair production cross sections are measured in pp collisions at a centre-of-mass energy of 7 TeV at the LHC with the CMS detector using data recorded in 2011 corresponding to an integrated luminosity of 5.0 inverse femtobarns. The measurements are performed in the lepton+jets decay channels (e+jets and mu+jets) and the dilepton decay channels (oppositely charged ee, mu mu, and e mu). The t t-bar differential cross section is measured as a function of kinematic properties of the final-state charged leptons and jets associated to b quarks, as well as those of the top quarks and the t t-bar system. The data are compared with several predictions from perturbative QCD calculations up to approximate next-to-next-to-leading-order precision. No significant deviations from the standard model are observed.

Journal ArticleDOI
TL;DR: Martizzi et al. as discussed by the authors used cosmological simulations to show that active galactic nuclei feedback on the gas distribution in clusters of galaxies can be important in determining the spatial distribution of stars and dark matter in the central regions of the systems.
Abstract: In a recent study (Martizzi et al 2012), we used cosmological simulations to show thatactive galactic nuclei (AGN) feedback on the gas distribution in clusters of galaxies canbe important in determining the spatial distribution of stars and dark matter in thecentralregionsofthese systemsThe hierarchicalassemblyof darkmatter, baryonsandblack holes obscures the physical mechanism behind the restructuring process Herewe use idealized simulations to follow the response of a massive dark matter halo aswe feed the central black hole with a controlled supply of cold gas This removes mostof the complexity taking place in the cosmological simulations that may have biasedour previous study We confirm our previous results: gas heated and expelled from thecentral regions of the halo by AGN feedback can return after cooling; repeated cyclesgenerate gravitational potential fluctuations responsible for irreversible modificationsof the dark matter mass profile The main result is the expulsion of large amountsof baryons and dark matter from the central regions of the halo According to thework presented here, outflow induced fluctuations represent the only mechanism ableto efficiently create dark matter cores in clusters of galaxiesKeywords: black hole physics – cosmology:theory – cosmology:large-scalestructureof Universe – galaxies: formation – galaxies: clusters: general – methods: numerical

Journal ArticleDOI
TL;DR: Understanding of recent observational, interventional, and experimental studies is presented, with the aim of providing some answers to the following question: Can n-3 FA intake modulate cognitive function during aging?

Journal ArticleDOI
TL;DR: Daily resveratrol consumption was well tolerated and has the potential to maintain healthy circulatory function in obese adults.
Abstract: Background: We have previously demonstrated acute dose-dependent increases of flow-mediated dilatation (FMD) in the brachial artery after resveratrol consumption in mildly hypertensive, overweight/obese adults. Resveratrol supplementation has also been shown to increase cerebral blood flow acutely, without affecting cognition. Objectives: To evaluate the effects of chronic resveratrol supplementation on both FMD and cognitive performance. Method: Twenty-eight obese but otherwise healthy adults (BMI: 33.3±0.6kg/m 2) were randomized to take a single 75 mg capsule of trans-resveratrol (Resvida) or placebo daily for 6 weeks each in a double-blind crossover supplementation trial. Blood pressure, arterial compliance, FMD, and performance on the Stroop Color-Word Test were assessed at the end of each 6-week intervention period while fasted and at least 18 h after taking the last daily capsule. An additional capsule of the same supplement was then taken. FMD assessment was repeated 1 h later. Results: Chronic resveratrol supplementation for 6 weeks was well tolerated and resulted in a 23% increase in FMD compared with placebo (P = 0.021, paired t-test). The extent of increase correlated negatively with baseline FMD (r= -0.47, P=0.01). A single dose of resveratrol (75 mg) following chronic resveratrol supplementation resulted in a 35% greater acute FMD response than the equivalent placebo supplementation. These FMD improvements remained significant after adjusting for baseline FMD. Blood pressure, arterial compliance, and all components of the Stroop Color-Word Test were unaffected by chronic resveratrol supplementation. Conclusion: Daily resveratrol consumption was well tolerated and has the potential to maintain healthy circulatory function in obese adults.

Book ChapterDOI
Cord C. Uphoff1, Hans G. Drexler
TL;DR: The described assay can be performed in less than 3 hours, including sample preparation, DNA extraction, PCR run, and analysis of the PCR products, and special emphasis is given to steps taken to avoid false-negative results due to the presence of inhibitors of the Taq polymerase in the crude samples.
Abstract: Mycoplasma contamination of cell lines is one of the major problems in cell culture technology. The -specific, sensitive, and reliable detection of mycoplasma contamination is an important part of mycoplasma control and should be an established method in every cell culture laboratory. New cell lines as well as cell lines in continuous culture must be tested in regular intervals. The polymerase chain reaction (PCR) methodology offers a fast and sensitive technique to monitor all cultures in a laboratory and can also be used to determine the contaminating species.The described assay can be performed in less than 3 hours, including sample preparation, DNA extraction, PCR run, and analysis of the PCR products. Special emphasis is given to steps taken to avoid false-negative results due to the presence of inhibitors of the Taq polymerase in the crude samples and the interpretation of the results. The technique can also be adapted to the requirements of the pharmacopoeia.

Journal ArticleDOI
TL;DR: An integrated measure of total macular pigment optical density, which can be measured non-invasively, has the potential to be used as a biomarker to assess brain lutein and zeaxanthin status.
Abstract: ObjectivesXanthophyll pigments lutein and zeaxanthin cross the blood–retina barrier to preferentially accumulate in the macular region of the neural retina. There they form macular pigment, protecting the retina from blue light damage and oxidative stress. Lutein and zeaxanthin also accumulate in brain tissue. The objective of the study was to evaluate the relationship between retinal and brain levels of these xanthophylls in non-human primates.MethodsStudy animals included rhesus monkeys reared on diets devoid of xanthophylls that were subsequently fed pure lutein or pure zeaxanthin (both at 3.9 µmol/kg per day, n = 6/group) and normal rhesus monkeys fed a stock diet (0.26 µmol/kg per day lutein and 0.24 µmol/kg per day zeaxanthin, n = 5). Retina (4 mm macular punch, 4–8 mm annulus, and periphery) and brain tissue (cerebellum, frontal cortex, occipital cortex, and pons) from the same animals were analyzed by reverse-phase high-performance liquid chromatography.ResultsLutein in the macula and annu...

Journal ArticleDOI
TL;DR: In this paper, the value of continuous processing in green chemistry has been discussed, and the magnitude and timing of effects and the relation to the principles of green chemistry were investigated. But, the authors focused on the importance of the green chemistry principles to the success of continuous processes.

Journal ArticleDOI
TL;DR: A systematic review of total amino acid (TAA) and free amino Acid (FAA) profiles, in term and preterm HM derived from 13 and 19 countries, shows some significant differences were observed, based on gestational age and region.
Abstract: Amino acid profile is a key aspect of human milk (HM) protein quality We report a systematic review of total amino acid (TAA) and free amino acid (FAA) profiles, in term and preterm HM derived from 13 and 19 countries, respectively Of the 83 studies that were critically reviewed, 26 studies with 3774 subjects were summarized for TAA profiles, while 22 studies with 4747 subjects were reviewed for FAA Effects of gestational age, lactation stage, and geographical region were analyzed by Analysis of Variance Data on total nitrogen (TN) and TAA composition revealed general inter-study consistency, whereas FAA concentrations varied among studies TN and all TAA declined in the first two months of lactation and then remained relatively unchanged In contrast, the FAA glutamic acid and glutamine increased, peaked around three to six months, and then declined Some significant differences were observed for TAA and FAA, based on gestational age and region Most regional TAA and FAA data were derived from Asia and Europe, while information from Africa was scant This systematic review represents a useful evaluation of the amino acid composition of human milk, which is valuable for the assessment of protein quality of breast milk substitutes

Journal ArticleDOI
Peter A. R. Ade1, Nabila Aghanim2, Monique Arnaud3, M. Ashdown4  +227 moreInstitutions (61)
TL;DR: Using precise full-sky observations from Planck, and applying several methods of component separation, the authors of as discussed by the authors identify and characterise the emission from the Galactic haze at microwave wavelengths.
Abstract: Using precise full-sky observations from Planck, and applying several methods of component separation, we identify and characterise the emission from the Galactic “haze” at microwave wavelengths The haze is a distinct component of diffuse Galactic emission, roughly centered on the Galactic centre, and extends to | b | ~ 35−50° in Galactic latitude and | l | ~ 15−20° in longitude By combining the Planck data with observations from the Wilkinson Microwave Anisotropy Probe, we were able to determine the spectrum of this emission to high accuracy, unhindered by the strong systematic biases present in previous analyses The derived spectrum is consistent with power-law emission with a spectral index of −256 ± 005, thus excluding free-free emission as the source and instead favouring hard-spectrum synchrotron radiation from an electron population with a spectrum (number density per energy) dN/dE ∝ E-21 At Galactic latitudes | b | < 30°, the microwave haze morphology is consistent with that of the Fermi gamma-ray “haze” or “bubbles”, while at b ~ −50° we have identified an edge in the microwave haze that is spatially coincident with the edge in the gamma-ray bubbles Taken together, this indicates that we have a multi-wavelength view of a distinct component of our Galaxy Given both the very hard spectrum and the extended nature of the emission, it is highly unlikely that the haze electrons result from supernova shocks in the Galactic disk Instead, a new astrophysical mechanism for cosmic-ray acceleration in the inner Galaxy is implied

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TL;DR: In this article, the authors analyzed the temporal characteristics in the X-rays, near-UV, and gamma rays and studied the broad-band spectral energy distribution from radio to gamma rays.
Abstract: Context. XSS J1227.0-4859 is a peculiar, hard X-ray source recently positionally associated to the Fermi-LAT source 1FGL J1227.9-4852/2FGL J1227.7-4853. Multi-wavelength observations have added information on this source, indicating a low-luminosity low-mass X-ray binary (LMXB), but its nature is still unclear.Aims. To progress in our understanding, we present new X-ray data from a monitoring campaign performed in 2011 with the XMM-Newton, RXTE, and Swift satellites and combine them with new gamma-ray data from the Fermi and AGILE satellites. We complement the study with simultaneous near-UV photometry from XMM-Newton and with previous UV/optical and near-IR data.Methods. We analysed the temporal characteristics in the X-rays, near-UV, and gamma rays and studied the broad-band spectral energy distribution from radio to gamma rays.Results. The X-ray history of XSS J1227 over 7 yr shows a persistent and rather stable low-luminosity (6 × 1033 d1 kpc2 erg s-1) source, with flares and dips being peculiar and permanent characteristics. The associated Fermi-LAT source 2FGL J1227.7-4853 is also stable over an overlapping period of 4.7 yr. Searches for X-ray fast pulsations down to msec give upper limits to pulse fractional amplitudes of 15−25% that do not rule out a fast spinning pulsar. The combined UV/optical/near-IR spectrum reveals a hot component at ~13 kK and a cool one at ~4.6 kK. The latter would suggest a late-type K2−K5 companion star, a distance range of 1.4−3.6 kpc, and an orbital period of 7–9 h. A near-UV variability (≳6 h) also suggests a longer orbital period than previously estimated. Conclusions. The analysis shows that the X-ray and UV/optical/near-IR emissions are more compatible with an accretion-powered compact object than with a rotational powered pulsar. The X-ray to UV bolometric luminosity ratio could be consistent with a binary hosting a neutron star, but the uncertainties in the radio data may also allow an LMXB black hole with a compact jet. In this case, it would be the first associated with a high-energy gamma-ray source.

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TL;DR: In this paper, spectra and light curves of SNLS 06D4eu and SNLS 07D2bv, two hydrogen-free superluminous supernovae (SNe) discovered by the Supernova Legacy Survey, were presented.
Abstract: We present spectra and light curves of SNLS 06D4eu and SNLS 07D2bv, two hydrogen-free superluminous supernovae (SNe) discovered by the Supernova Legacy Survey. At z = 1.588, SNLS 06D4eu is the highest redshift superluminous SN with a spectrum, at MU = –22.7 it is one of the most luminous SNe ever observed, and it gives a rare glimpse into the rest-frame ultraviolet where these SNe put out their peak energy. SNLS 07D2bv does not have a host galaxy redshift, but on the basis of the SN spectrum, we estimate it to be at z ~ 1.5. Both SNe have similar observer-frame griz light curves, which map to rest-frame light curves in the U band and UV, rising in ~20 rest-frame days or longer and declining over a similar timescale. The light curves peak in the shortest wavelengths first, consistent with an expanding blackbody starting near 15,000 K and steadily declining in temperature. We compare the spectra with theoretical models, and we identify lines of C II, C III, Fe III, and Mg II in the spectra of SNLS 06D4eu and SCP 06F6 and find that they are consistent with an expanding explosion of only a few solar masses of carbon, oxygen, and other trace metals. Thus, the progenitors appear to be related to those suspected for SNe Ic. A high kinetic energy, 1052 erg, is also favored. Normal mechanisms of powering core-collapse or thermonuclear SNe do not seem to work for these SNe. We consider models powered by 56Ni decay and interaction with circumstellar material, but we find that the creation and spin-down of a magnetar with a period of 2 ms, a magnetic field of 2 × 1014 G, and a 3 M ☉ progenitor provides the best fit to the data.

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Peter A. R. Ade1, Nabila Aghanim2, Monique Arnaud3, M. Ashdown  +208 moreInstitutions (54)
TL;DR: In this paper, the authors present an analysis of Planck satellite data on the Coma cluster observed via the Sunyaev-Zeldovich effect, which is able to detect SZ emission up to r ≈ 3 × R500.
Abstract: We present an analysis of Planck satellite data on the Coma cluster observed via the Sunyaev-Zeldovich effect. Thanks to its great sensitivity, Planck is able, for the first time, to detect SZ emission up to r ≈ 3 × R500. We test previously proposed spherically symmetric models for the pressure distribution in clusters against the azimuthally averaged data. In particular, we find that the Arnaud et al. (2010, AA by r = 2 × R500 it underestimates the observed y profile by a factor of ≃2. This may indicate that at these larger radii either: i) the cluster SZ emission is contaminated by unresolved SZ sources along the line of sight; or ii) the pressure profile of Coma is higher at r > R500 than the mean pressure profile predicted by the simulations used to constrain the models. The Planck image shows significant local steepening of the y profile in two regions about half a degree to the west and to the south-east of the cluster centre. These features are consistent with the presence of shock fronts at these radii, and indeed the western feature was previously noticed in the ROSAT PSPC mosaic as well as in the radio. Using Plancky profiles extracted from corresponding sectors we find pressure jumps of 4.9-0.2+0.4 and 5.0-0.1+1.3 in the west and south-east, respectively. Assuming Rankine-Hugoniot pressure jump conditions, we deduce that the shock waves should propagate with Mach number Mw = 2.03-0.04+0.09 and Mse = 2.05-0.02+0.25 in the west and south-east, respectively. Finally, we find that the y and radio-synchrotron signals are quasi-linearly correlated on Mpc scales, with small intrinsic scatter. This implies either that the energy density of cosmic-ray electrons is relatively constant throughout the cluster, or that the magnetic fields fall off much more slowly with radius than previously thought.

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TL;DR: In this article, the authors characterize the incidence of active galactic nuclei (AGNs) in 0.3 < z < 1 star-forming galaxies by applying multi-wavelength AGN diagnostics (X-ray, optical, mid-infrared, radio) to a sample of galaxies selected at 70 μm from the Far-Infrared Deep Extragalactic Legacy survey (FIDEL).
Abstract: We characterize the incidence of active galactic nuclei (AGNs) in 0.3 < z < 1 star-forming galaxies by applying multi-wavelength AGN diagnostics (X-ray, optical, mid-infrared, radio) to a sample of galaxies selected at 70 μm from the Far-Infrared Deep Extragalactic Legacy survey (FIDEL). Given the depth of FIDEL, we detect "normal" galaxies on the specific star formation rate (sSFR) sequence as well as starbursting systems with elevated sSFR. We find an overall high occurrence of AGN of 37% ± 3%, more than twice as high as in previous studies of galaxies with comparable infrared luminosities and redshifts but in good agreement with the AGN fraction of nearby (0.05 < z < 0.1) galaxies of similar infrared luminosities. The more complete census of AGNs comes from using the recently developed Mass-Excitation (MEx) diagnostic diagram. This optical diagnostic is also sensitive to X-ray weak AGNs and X-ray absorbed AGNs, and reveals that absorbed active nuclei reside almost exclusively in infrared-luminous hosts. The fraction of galaxies hosting an AGN appears to be independent of sSFR and remains elevated both on the sSFR sequence and above. In contrast, the fraction of AGNs that are X-ray absorbed increases substantially with increasing sSFR, possibly due to an increased gas fraction and/or gas density in the host galaxies.

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TL;DR: In this article, the authors evaluate the impact of active galactic nuclei (AGN) on galaxy mass content, BH self-regulation, and gas distribution inside this massive halo.
Abstract: Supermassive black holes (BH) are powerful sources of energy that are already in place at very early epochs of the Universe (by z=6). Using hydrodynamical simulations of the formation of a massive M_vir=5 10^11 M_sun halo by z=6 (the most massive progenitor of a cluster of M_vir=2 10^15 M_sun at z=0), we evaluate the impact of Active Galactic Nuclei (AGN) on galaxy mass content, BH self-regulation, and gas distribution inside this massive halo. We find that SN feedback has a marginal influence on the stellar structure, and no influence on the mass distribution on large scales. In contrast, AGN feedback alone is able to significantly alter the stellar-bulge mass content by quenching star formation when the BH is self-regulating, and by depleting the cold gas reservoir in the centre of the galaxy. The growth of the BH proceeds first by a rapid Eddington-limited period fed by direct cold filamentary infall. When the energy delivered by the AGN is sufficiently large to unbind the cold gas of the bulge, the accretion of gas onto the BH is maintained both by smooth gas inflow and clump migration through the galactic disc triggered by merger-induced torques. The feedback from the AGN has also a severe consequence on the baryon mass content within the halo, producing large-scale hot superwinds, able to blow away some of the cold filamentary material from the centre and reduce the baryon fraction by more than 30 per cent within the halo's virial radius. Thus in the very young universe, AGN feedback is likely to be a key process, shaping the properties of the most massive galaxies.