Institution
Linköping University
Education•Linköping, Sweden•
About: Linköping University is a education organization based out in Linköping, Sweden. It is known for research contribution in the topics: Population & Health care. The organization has 15671 authors who have published 50013 publications receiving 1542189 citations.
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TL;DR: Subcellular events during tumor necrosis factor-induced necroptosis, H2O2-induced necrosis and anti-Fas-induced secondary necrosis were studied using high-resolution time-lapse microscopy to characterize the cellular disintegration phase of the three types of necrosis.
Abstract: Necroptosis, necrosis and secondary necrosis following apoptosis represent different modes of cell death that eventually result in similar cellular morphology including rounding of the cell, cytoplasmic swelling, rupture of the plasma membrane and spilling of the intracellular content. Subcellular events during tumor necrosis factor (TNF)-induced necroptosis, H2O2-induced necrosis and anti-Fas-induced secondary necrosis were studied using high-resolution time-lapse microscopy. The cellular disintegration phase of the three types of necrosis is characterized by an identical sequence of subcellular events, including oxidative burst, mitochondrial membrane hyperpolarization, lysosomal membrane permeabilization and plasma membrane permeabilization, although with different kinetics. H2O2-induced necrosis starts immediately by lysosomal permeabilization. In contrast, during TNF-mediated necroptosis and anti-Fas-induced secondary necrosis, this is a late event preceded by a defined signaling phase. TNF-induced necroptosis depends on receptor-interacting protein-1 kinase, mitochondrial complex I and cytosolic phospholipase A(2) activities, whereas H2O2-induced necrosis requires iron-dependent Fenton reactions.
512 citations
TL;DR: The COVID-19 pandemic : The 'black swan' for mental health care and a turning point for e-health.
507 citations
TL;DR: In this paper, the authors present arguments for using extant literature in the substantive field within a constructivist grounded theory, and suggest data sensitizing principles in using literature, which are: theoretical agnosticism, theoretical pluralism, theoretical sampling of literature, staying grounded, theoretical playfulness, memoing extant knowledge associations, and constant reflexivity.
Abstract: There is a widespread idea that in grounded theory (GT) research, the researcher has to delay the literature review until the end of the analysis to avoid contamination – a dictum that might turn educational researchers away from GT. Nevertheless, in this article the author (a) problematizes the dictum of delaying a literature review in classic grounded theory, (b) presents arguments for using extant literature in the substantive field within a constructivist grounded theory, and (c) suggests data sensitizing principles in using literature, which are: theoretical agnosticism, theoretical pluralism, theoretical sampling of literature, staying grounded, theoretical playfulness, memoing extant knowledge associations, and constant reflexivity.
507 citations
TL;DR: X-ray photoelectron spectroscopy (XPS) has been used to characterize poly(3,4-ethylene dioxythiophene)-poly(styrene sulfonate) (PEDT/PSS) as discussed by the authors.
Abstract: X-ray photoelectron spectroscopy (XPS) has been used to characterize poly(3,4-ethylene dioxythiophene)-poly(styrene sulfonate) (PEDT/PSS), one of the most common electrically conducting organic pol ...
502 citations
Haramaya University1, Université de Montréal2, Université de Moncton3, National Heart Foundation of Australia4, University of Ibadan5, University of La Frontera6, University of Cuenca7, University of Waterloo8, University of the Republic9, Ghent University10, National Taiwan University11, Karolinska Institutet12, University of Ottawa13, Technische Universität München14, University of Cape Town15, University of the Witwatersrand16, Swansea University17, Lithuanian Sports University18, Emory University19, University of Los Andes20, Central University of Venezuela21, Hong Kong Baptist University22, Qatar Airways23, University of Tartu24, University of Regina25, Mahidol University26, The Chinese University of Hong Kong27, Pennington Biomedical Research Center28, University of Queensland29, Seoul National University30, Queen's University31, Linköping University32, University of Medicine and Health Sciences33, University of Guadalajara34, Shanghai University of Sport35, National University of Science and Technology36, University of Primorska37, University of Porto38, University of Ghana39, University of Strathclyde40, Carlos III Health Institute41, University of Girona42, Universidade Federal de Santa Catarina43, Katholieke Universiteit Leuven44, University of South Australia45, University of Southern Denmark46, University of Auckland47, Bath Spa University48, University of Ljubljana49, Tribhuvan University50, Utrecht University51, J. F. Oberlin University52, University of Botswana53, Stamford University Bangladesh54, National Chung Hsing University55, University of Warsaw56
TL;DR: The present study provides rich new evidence showing that the situation regarding the physical activity of children and youth is a concern worldwide and strategic public investments to implement effective interventions to increase physical activity opportunities are needed.
Abstract: Background: Accumulating sufficient moderate to vigorous physical activity is recognized as a key determinant of physical, physiological, developmental, mental, cognitive, and social health among children and youth (aged 5–17 y). The Global Matrix 3.0ofReportCardgradesonphysicalactivitywasdevelopedtoachieveabetterunderstandingoftheglobalvariationinchildand youth physical activity and associated supports. Methods: Work groups from 49 countries followed harmonized procedures to develop their Report Cards by grading 10 common indicators using the best available data. The participating countries were divided into 3 categories using the United Nations’ human development index (HDI) classification (low or medium, high, and very high HDI). Results: A total of 490 grades, including 369 letter grades and 121 incomplete grades, were assigned by the 49 work groups. Overall, an average grade of “C−,”“D+,” and “C−” was obtained for the low and medium HDI countries, high HDI countries, and very high HDI countries, respectively. Conclusions: The present study provides rich new evidence showing that the situation regarding the physical activity of children and youth is a concern worldwide. Strategic public investments to implement effective interventions to increase physical activity opportunities are needed.
502 citations
Authors
Showing all 15844 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Rui Zhang | 151 | 2625 | 107917 |
| Jun Lu | 135 | 1526 | 99767 |
| Jean-Luc Brédas | 134 | 1026 | 85803 |
| Lars Wallentin | 124 | 767 | 61020 |
| S. Shankar Sastry | 122 | 858 | 86155 |
| Gerhard Andersson | 118 | 902 | 49159 |
| Olle Inganäs | 113 | 627 | 50562 |
| Antonio Facchetti | 111 | 602 | 51885 |
| Ray H. Baughman | 110 | 616 | 60009 |
| Michel W. Barsoum | 106 | 543 | 60539 |
| Louis J. Ignarro | 106 | 335 | 46008 |
| Per Björntorp | 105 | 386 | 40321 |
| Jan Lubinski | 103 | 689 | 52120 |
| Magnus Johannesson | 102 | 342 | 40776 |
| Barbara Riegel | 101 | 507 | 77674 |