Showing papers by "Linköping University published in 2013"
Katholieke Universiteit Leuven1, Gdańsk Medical University2, University of Valencia3, Zamorano4, Ghent University5, Charles University in Prague6, University of Glasgow7, University of Naples Federico II8, University Medical Center Utrecht9, Linköping University10, University of Birmingham11, University of Oslo12, Lund University13, Complutense University of Madrid14, University of Erlangen-Nuremberg15, John Radcliffe Hospital16, Tallinn University of Technology17, University of Lausanne18
TL;DR: 2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the management of Arterspertension of the European Society ofhypertension (ESH) and of theEuropean Society of Cardiology (ESC).
Abstract: Because of new evidence on several diagnostic and therapeutic aspects of hypertension, the present guidelines differ in many respects from the previous ones. Some of the most important differences are listed below:
1. Epidemiological data on hypertension and BP control in Europe.
2. Strengthening of the prognostic value of home blood pressure monitoring (HBPM) and of its role for diagnosis and management of hypertension, next to ambulatory blood pressure monitoring (ABPM).
3. Update of the prognostic significance of night-time BP, white-coat hypertension and masked hypertension.
4. Re-emphasis on integration of BP, cardiovascular (CV) risk factors, asymptomatic organ damage (OD) and clinical complications for total CV risk assessment.
5. Update of the prognostic significance of asymptomatic OD, including heart, blood vessels, kidney, eye and brain.
6. Reconsideration of the risk of overweight and target body mass index (BMI) in hypertension.
7. Hypertension in young people.
8. Initiation of antihypertensive treatment. More evidence-based criteria and no drug treatment of high normal BP.
9. Target BP for treatment. More evidence-based criteria and unified target systolic blood pressure (SBP) (<140 mmHg) in both higher and lower CV risk patients.
10. Liberal approach to initial monotherapy, without any all-ranking purpose.
11. Revised schema for priorital two-drug combinations.
12. New therapeutic algorithms for achieving target BP.
13. Extended section on therapeutic strategies in special conditions.
14. Revised recommendations on treatment of hypertension in the elderly.
15. Drug treatment of octogenarians.
16. Special attention to resistant hypertension and new treatment approaches.
17. Increased attention to OD-guided therapy.
18. New approaches to chronic management of hypertensive disease
7,018 citations
TL;DR: In this paper, the tradeoff between the energy efficiency and spectral efficiency of a single-antenna system is quantified for a channel model that includes small-scale fading but not large scale fading, and it is shown that the use of moderately large antenna arrays can improve the spectral and energy efficiency with orders of magnitude compared to a single antenna system.
Abstract: A multiplicity of autonomous terminals simultaneously transmits data streams to a compact array of antennas. The array uses imperfect channel-state information derived from transmitted pilots to extract the individual data streams. The power radiated by the terminals can be made inversely proportional to the square-root of the number of base station antennas with no reduction in performance. In contrast if perfect channel-state information were available the power could be made inversely proportional to the number of antennas. Lower capacity bounds for maximum-ratio combining (MRC), zero-forcing (ZF) and minimum mean-square error (MMSE) detection are derived. An MRC receiver normally performs worse than ZF and MMSE. However as power levels are reduced, the cross-talk introduced by the inferior maximum-ratio receiver eventually falls below the noise level and this simple receiver becomes a viable option. The tradeoff between the energy efficiency (as measured in bits/J) and spectral efficiency (as measured in bits/channel use/terminal) is quantified for a channel model that includes small-scale fading but not large-scale fading. It is shown that the use of moderately large antenna arrays can improve the spectral and energy efficiency with orders of magnitude compared to a single-antenna system.
2,770 citations
TL;DR: New two-dimensional niobium and vanadium carbides have been synthesized by selective etching, at room temperature, of Al from Nb2 AlC and V2AlC, demonstrating good capability to handle high charge-discharge rates.
Abstract: New two-dimensional niobium and vanadium carbides have been synthesized by selective etching, at room temperature, of Al from Nb2AlC and V2AlC, respectively. These new matrials are promising electrode materials for Li-ion batteries, demonstrating good capability to handle high charge–discharge rates. Reversible capacities of 170 and 260 mA·h·g–1 at 1 C, and 110 and 125 mA·h·g–1 at 10 C were obtained for Nb2C and V2C-based electrodes, respectively.
1,444 citations
TL;DR: This cellular thermal shift assay (CETSA) is based on the biophysical principle of ligand-induced thermal stabilization of target proteins and validated drug binding for a set of important clinical targets and monitored processes of drug transport and activation, off-target effects and drug resistance in cancer cell lines, as well as drug distribution in tissues.
Abstract: The efficacy of therapeutics is dependent on a drug binding to its cognate target. Optimization of target engagement by drugs in cells is often challenging, because drug binding cannot be monitored inside cells. We have developed a method for evaluating drug binding to target proteins in cells and tissue samples. This cellular thermal shift assay (CETSA) is based on the biophysical principle of ligand-induced thermal stabilization of target proteins. Using this assay, we validated drug binding for a set of important clinical targets and monitored processes of drug transport and activation, off-target effects and drug resistance in cancer cell lines, as well as drug distribution in tissues. CETSA is likely to become a valuable tool for the validation and optimization of drug target engagement.
1,305 citations
Ashley Beecham1, Nikolaos A. Patsopoulos2, Nikolaos A. Patsopoulos3, Dionysia K. Xifara4 +203 more•Institutions (73)
TL;DR: This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.
Abstract: Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 10 × 10(-4)) In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 50 × 10(-8)), 3 of which we found after conditioning on previously identified variants Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals
1,197 citations
TL;DR: A review of the field of biosensors can be found in this article, where the authors discuss the reasons for success, some of the more exciting emerging technologies, and speculates on the importance of sensors as a ubiquitous technology of the future for health and the maintenance of wellbeing.
Abstract: This review is based on the Theophilus Redwood Medal and Award lectures, delivered to Royal Society of Chemistry meetings in the UK and Ireland in 2012, and presents a personal overview of the field of biosensors. The biosensors industry is now worth billions of United States dollars, the topic attracts the attention of national initiatives across the world and tens of thousands of papers have been published in the area. This plethora of information is condensed into a concise account of the key achievements to date. The reasons for success are examined, some of the more exciting emerging technologies are highlighted and the author speculates on the importance of biosensors as a ubiquitous technology of the future for health and the maintenance of wellbeing.
1,160 citations
Katholieke Universiteit Leuven1, Gdańsk Medical University2, University of Valencia3, Ghent University4, Charles University in Prague5, University of Glasgow6, University of Naples Federico II7, Utrecht University8, Linköping University9, University of Münster10, University of Oslo11, Complutense University of Madrid12, University of Erlangen-Nuremberg13, John Radcliffe Hospital14, Tallinn University of Technology15, University of Lausanne16
TL;DR: The 2013 European Society of Hypertension/European Society of Cardiology (ESH/ESC) guidelines continue to adhere to some fundamental principles that inspired the 2003 and 2007 guidelines, namely to base recommendations on properly conducted studies identified from an ext
Abstract: 1. INTRODUCTION1.1 PrinciplesThe 2013 European Society of Hypertension/European Society of Cardiology (ESH/ESC) guidelines continue to adhere to some fundamental principles that inspired the 2003 and 2007 guidelines, namely to base recommendations on properly conducted studies identified from an ext
1,139 citations
TL;DR: The ESC‐HF Pilot survey was aimed to describe clinical epidemiology and 1‐year outcomes of outpatients and inpatients with heart failure and validating structure, performance, and quality of the data set for continuing the survey into a permanent Registry.
Abstract: The ESC-HF Pilot survey was aimed to describe clinical epidemiology and 1-year outcomes of outpatients and inpatients with heart failure (HF). The pilot phase was also specifically aimed at validating structure, performance, and quality of the data set for continuing the survey into a permanent Registry. The ESC-HF Pilot study is a prospective, multicentre, observational survey conducted in 136 Cardiology Centres in 12 European countries selected to represent the different health systems across Europe. All outpatients with HF and patients admitted for acute HF on 1 day per week for eight consecutive months were included. From October 2009 to May 2010, 5118 patients were included: 1892 (37) admitted for acute HF and 3226 (63) patients with chronic HF. The all-cause mortality rate at 1 year was 17.4 in acute HF and 7.2 in chronic stable HF. One-year hospitalization rates were 43.9 and 31.9, respectively, in hospitalized acute and chronic HF patients. Major regional differences in 1-year mortality were observed that could be explained by differences in characteristics and treatment of the patients. The ESC-HF Pilot survey confirmed that acute HF is still associated with a very poor medium-term prognosis, while the widespread adoption of evidence-based treatments in patients with chronic HF seems to have improved their outcome profile. Differences across countries may be due to different local medical practice as well to differences in healthcare systems. This pilot study also offered the opportunity to refine the organizational structure for a long-term extended European network.
676 citations
TL;DR: This paper examines the Ease of Language Understanding model in light of new behavioral and neural findings concerning the role of working memory capacity (WMC) in uni-modal and bimodal language processing.
Abstract: Working memory is important for online language processing during conversation. We use it to maintain relevant information, to inhibit or ignore irrelevant information, and to attend to conversation selectively. Working memory helps us to keep track of and actively participate in conversation, including taking turns and following the gist. This paper examines the Ease of Language Understanding model (i.e., the ELU model, Ronnberg, 2003; Ronnberg et al., 2008) in light of new behavioral and neural findings concerning the role of working memory capacity (WMC) in uni-modal and bimodal language processing. The new ELU model is a meaning prediction system that depends on phonological and semantic interactions in rapid implicit and slower explicit processing mechanisms that both depend on WMC albeit in different ways. It is based on findings that address the relationship between WMC and (a) early attention processes in listening to speech, (b) signal processing in hearing aids and its effects on short-term memory, (c) inhibition of speech maskers and its effect on episodic long-term memory, (d) the effects of hearing impairment on episodic and semantic long-term memory, and finally, (e) listening effort. New predictions and clinical implications are outlined. Comparisons with other WMC and speech perception models are made.
676 citations
TL;DR: This review focuses on lysosomal involvement in digestion of intra- and extracellular material, plasma membrane repair, cholesterol homeostasis, and cell death.
Abstract: Lysosomes are ubiquitous membrane-bound intracellular organelles with an acidic interior. They are central for degradation and recycling of macromolecules delivered by endocytosis, phagocytosis, and autophagy. In contrast to the rather simplified view of lysosomes as waste bags, nowadays lysosomes are recognized as advanced organelles involved in many cellular processes and are considered crucial regulators of cell homeostasis. The function of lysosomes is critically dependent on soluble lysosomal hydrolases (e.g. cathepsins) as well as lysosomal membrane proteins (e.g. lysosome-associated membrane proteins). This review focuses on lysosomal involvement in digestion of intra- and extracellular material, plasma membrane repair, cholesterol homeostasis, and cell death. Regulation of lysosomal biogenesis and function via the transcription factor EB (TFEB) will also be discussed. In addition, lysosomal contribution to diseases, including lysosomal storage disorders, neurodegenerative disorders, cancer, and cardiovascular diseases, is presented.
645 citations
TL;DR: The microbial community of 21 full-scale biogas reactors was examined using 454 pyrosequencing of 16S rRNA gene sequences and revealed that methane formation from acetate takes place mainly via syntrophic acetate oxidation in the CD reactors.
TL;DR: It is concluded that infants, similarly to rodents, have the bona fide iBAT thermogenic organ consisting of classical brown adipocytes that is essential for the survival of small mammals in a cold environment.
Abstract: The previously observed supraclavicular depot of brown adipose tissue (BAT) in adult humans was commonly believed to be the equivalent of the interscapular thermogenic organ of small mammals. This view was recently disputed on the basis of the demonstration that this depot consists of beige (also called brite) brown adipocytes, a newly identified type of brown adipocyte that is distinct from the classical brown adipocytes that make up the interscapular thermogenic organs of other mammals. A combination of high-resolution imaging techniques and histological and biochemical analyses showed evidence for an anatomically distinguishable interscapular BAT (iBAT) depot in human infants that consists of classical brown adipocytes, a cell type that has so far not been shown to exist in humans. On the basis of these findings, we conclude that infants, similarly to rodents, have the bona fide iBAT thermogenic organ consisting of classical brown adipocytes that is essential for the survival of small mammals in a cold environment.
Charité1, Linköping University2, Athens State University3, French Institute of Health and Medical Research4, Medical University of Łódź5, University Clinical Hospital Mostar6, University of Lisbon7, University of Graz8, Alexandria University9, Charles University in Prague10, Lithuanian University of Health Sciences11, Semmelweis University12, University of Brescia13
TL;DR: To evaluate how recommendations of European guidelines regarding pharmacological and non‐pharmacological treatments for heart failure are adopted in clinical practice, a large number of patients with HF are receiving treatment according to these guidelines.
Abstract: AimsTo evaluate how recommendations of European guidelines regarding pharmacological and non-pharmacological treatments for heart failure (HF) are adopted in clinical practice.Methods and resultsThe ESC-HF Long-Term Registry is a prospective, observational study conducted in 211 Cardiology Centres of 21 European and Mediterranean countries, members of the European Society of Cardiology (ESC). From May 2011 to April 2013, a total of 12 440 patients were enrolled, 40.5% with acute HF and 59.5% with chronic HF. Intravenous treatments for acute HF were heterogeneously administered, irrespective of guideline recommendations. In chronic HF, with reduced EF, renin-angiotensin system (RAS) blockers, beta-blockers, and mineralocorticoid antagonists (MRAs) were used in 92.2, 92.7, and 67.0% of patients, respectively. When reasons for non-adherence were considered, the real rate of undertreatment accounted for 3.2, 2.3, and 5.4% of the cases, respectively. About 30% of patients received the target dosage of these drugs, but a documented reason for not achieving the target dosage was reported in almost two-thirds of them. The more relevant reasons for non-implantation of a device, when clinically indicated, were related to doctor uncertainties on the indication, patient refusal, or logistical/cost issues.ConclusionThis pan-European registry shows that, while in patients with acute HF, a large heterogeneity of treatments exists, drug treatment of chronic HF can be considered largely adherent to recommendations of current guidelines, when the reasons for non-adherence are taken into account. Observations regarding the real possibility to adhere fully to current guidelines in daily clinical practice should be seriously considered when clinical practice guidelines have to be written. © 2013 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2013. For permissions please email: journals.permissions@oup.com
TL;DR: Injuries had a significant influence on performance in the league play and in European cups in male professional football, and the findings stress the importance of injury prevention to increase a team's chances of success.
Abstract: Background The influence of injuries on team performance in football has only been scarcely investigated. Aim To study the association between injury rates and team performance in the domestic league play, and in European cups, in male professional football. Methods 24 football teams from nine European countries were followed prospectively for 11 seasons (2001–2012), including 155 team-seasons. Individual training and match exposure and time-loss injuries were registered. To analyse the effect of injury rates on performance, a Generalised Estimating Equation was used to fit a linear regression on team-level data. Each team’s season injury rate and performance were evaluated using its own preceding season data for comparison in the analyses. Results 7792 injuries were reported during 1 026 104 exposure hours. The total injury incidence was 7.7 injuries/ 1000 h, injury burden 130 injury days lost/1000 h and player match availability 86%. Lower injury burden (p=0.011) and higher match availability (p=0.031) were associated with higher final league ranking. Similarly, lower injury incidence (p=0.035), lower injury burden (p<0.001) and higher match availability (p<0.001) were associated with increased points per league match. Finally, lower injury burden (p=0.043) and higher match availability (p=0.048) were associated with an increase in the Union of European Football Association (UEFA) Season Club Coefficient, reflecting success in the UEFAChampions League or Europa League. Conclusions Injuries had a significant influence on performance in the league play and in European cups in male professional football. The findings stress the importance of injury prevention to increase a team’s chances of success.
TL;DR: In this article, the authors identify key microfoundations forming the basis of successful realignment of a firm's dynamic capabilities so as to achieve a better fit with service innovation activities.
TL;DR: It is estimated that the breast cancer lifetime risks for the5% of BRCA1 carriers at lowest risk are 28%–50% compared to 81%–100% for the 5% at highest risk, and the ovarian cancer lifetime risk is 63% or higher, based on the known cancer risk-modifying loci.
Abstract: BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7 x 10(-8), HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4 x 10(-8), HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4 x 10(-8), HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific association. The 17q21.31 locus was also associated with ovarian cancer risk in 8,211 BRCA2 carriers (P = 2 x 10(-4)). These loci may lead to an improved understanding of the etiology of breast and ovarian tumors in BRCA1 carriers. Based on the joint distribution of the known BRCA1 breast cancer risk-modifying loci, we estimated that the breast cancer lifetime risks for the 5% of BRCA1 carriers at lowest risk are 28%-50% compared to 81%-100% for the 5% at highest risk. Similarly, based on the known ovarian cancer risk-modifying loci, the 5% of BRCA1 carriers at lowest risk have an estimated lifetime risk of developing ovarian cancer of 28% or lower, whereas the 5% at highest risk will have a risk of 63% or higher. Such differences in risk may have important implications for risk prediction and clinical management for BRCA1 carriers.
University of Oklahoma1, Oklahoma Medical Research Foundation2, University of Paris-Sud3, University Hospitals Birmingham NHS Foundation Trust4, Queen Elizabeth II Hospital5, Linköping University6, Uppsala University7, University of Bergen8, Stavanger University Hospital9, Veterans Health Administration10, Cincinnati Children's Hospital Medical Center11, Karolinska Institutet12, Örebro University13, King's College London14, University of Colorado Denver15, University of Minnesota16, Carolinas Medical Center17, Harvard University18, Washington University in St. Louis19, National Institutes of Health20, Hannover Medical School21, University of Adelaide22, Newcastle University23, Del Rosario University24
TL;DR: The results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others.
Abstract: Sjogren's syndrome is a common autoimmune disease (affecting ∼0.7% of European Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report results of a large-scale association study of Sjogren's syndrome. In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (Pmeta = 7.65 × 10(-114)), we establish associations with IRF5-TNPO3 (Pmeta = 2.73 × 10(-19)), STAT4 (Pmeta = 6.80 × 10(-15)), IL12A (Pmeta = 1.17 × 10(-10)), FAM167A-BLK (Pmeta = 4.97 × 10(-10)), DDX6-CXCR5 (Pmeta = 1.10 × 10(-8)) and TNIP1 (Pmeta = 3.30 × 10(-8)). We also observed suggestive associations (Pmeta < 5 × 10(-5)) with variants in 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others. These results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjogren's syndrome.
TL;DR: LSCI is used primarily to map flow systems, especially blood flow, and its limitations and problems are investigated.
Abstract: When laser light illuminates a diffuse object, it produces a random interference effect known as a speckle pattern. If there is movement in the object, the speckles fluctuate in intensity. These fluctuations can provide infor- mation about the movement. A simple way of accessing this information is to image the speckle pattern with an exposure time longer than the shortest speckle fluctuation time scale—the fluctuations cause a blurring of the speckle, leading to a reduction in the local speckle contrast. Thus, velocity distributions are coded as speckle con- trast variations. The same information can be obtained by using the Doppler effect, but producing a two-dimen- sional Doppler map requires either scanning of the laser beam or imaging with a high-speed camera: laser speckle contrast imaging (LSCI) avoids the need to scan and can be performed with a normal CCD- or CMOS-camera. LSCI is used primarily to map flow systems, especially blood flow. The development of LSCI is reviewed and its lim- itations and problems are investigated. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
TL;DR: A case is made for clinicians to consider measurement error (ME) indices Coefficient of Repeatability (CR) or the Smallest Real Difference (SRD) over relative reliability coefficients like the Pearson’s (r) and the Intraclass Correlation Coefficient (ICC) while selecting tools to measure change and inferring change as true.
Abstract: The use of standardised tools is an essential component of evidence-based practice. Reliance on standardised tools places demands on clinicians to understand their properties, strengths, and weaknesses, in order to interpret results and make clinical decisions. This paper makes a case for clinicians to consider measurement error (ME) indices Coefficient of Repeatability (CR) or the Smallest Real Difference (SRD) over relative reliability coefficients like the Pearson’s (r) and the Intraclass Correlation Coefficient (ICC), while selecting tools to measure change and inferring change as true. The authors present statistical methods that are part of the current approach to evaluate test–retest reliability of assessment tools and outcome measurements. Selected examples from a previous test–retest study are used to elucidate the added advantages of knowledge of the ME of an assessment tool in clinical decision making. The CR is computed in the same units as the assessment tool and sets the boundary of the minimal detectable true change that can be measured by the tool.
TL;DR: Analytical and numerical results show that, under certain mild conditions on the channel gains, for a fixed M, an array gain is achievable even under the stringent per-antenna CE constraint, and the proposed CE precoding scheme performs close to the sum-capacity achieving scheme for an average-only total transmit power constrained channel.
Abstract: We consider the multi-user MIMO broadcast channel with M single-antenna users and N transmit antennas under the constraint that each antenna emits signals having constant envelope (CE). The motivation for this is that CE signals facilitate the use of power-efficient RF power amplifiers. Analytical and numerical results show that, under certain mild conditions on the channel gains, for a fixed M, an array gain is achievable even under the stringent per-antenna CE constraint. Essentially, for a fixed M, at sufficiently large N the total transmitted power can be reduced with increasing N while maintaining a fixed information rate to each user. Simulations for the i.i.d. Rayleigh fading channel show that the total transmit power can be reduced linearly with increasing N (i.e., an O(N) array gain). We also propose a precoding scheme which finds near-optimal CE signals to be transmitted, and has O(MN) complexity. Also, in terms of the total transmit power required to achieve a fixed desired information sum-rate, despite the stringent per-antenna CE constraint, the proposed CE precoding scheme performs close to the sum-capacity achieving scheme for an average-only total transmit power constrained channel.
TL;DR: In this article, the influence of the energy input parameters (80-900°C preheating temperature and 0.08-0.28m/s laser scanning speed) on microstructure and geometry of single tracks fabricated of stainless steel grade 316L powder was analyzed.
TL;DR: For a given BNP level, the prognosis in patients with HFPEF is as poor as in those with reduced LVEF, and if similar levels of BNP were compared across the whole spectrum of LVEf, and for different cutoff levels of LveF, the associated risk of adverse outcome was similar in HFP EF patients as inThose with reducedLVEF.
TL;DR: This review presents the past and present work on GPU accelerated medical image processing, and is meant to serve as an overview and introduction to existing GPU implementations.
TL;DR: In this article, the authors developed a thorough and accurate method of determining anharmonic free energies based on ab initio molecular dynamics and map a model Hamiltonian to the fully anharmoric free energy.
Abstract: We have developed a thorough and accurate method of determining anharmonic free energies. The technique is based in ab initio molecular dynamics and map a model Hamiltonian to the fully anharmonic ...
TL;DR: This work considers multicell multiuser MIMO systems with a very large number of antennas at the base station (BS) and shows that when the number of BS antennas goes to infinity, the system performance under a finite-dimensional channel model with P angular bins is the same as the performance under an uncorrelated channel models with P antennas.
Abstract: We consider multicell multiuser MIMO systems with a very large number of antennas at the base station (BS). We assume that the channel is estimated by using uplink training. We further consider a physical channel model where the angular domain is separated into a finite number of distinct directions. We analyze the so-called pilot contamination effect discovered in previous work, and show that this effect persists under the finite-dimensional channel model that we consider. In particular, we consider a uniform array at the BS. For this scenario, we show that when the number of BS antennas goes to infinity, the system performance under a finite-dimensional channel model with P angular bins is the same as the performance under an uncorrelated channel model with P antennas. We further derive a lower bound on the achievable rate of uplink data transmission with a linear detector at the BS. We then specialize this lower bound to the cases of maximum-ratio combining (MRC) and zero-forcing (ZF) receivers, for a finite and an infinite number of BS antennas. Numerical results corroborate our analysis and show a comparison between the performances of MRC and ZF in terms of sum-rate.
TL;DR: Intrinsic factors found to increase muscle injury rates in professional soccer were previous injury, older age, and kicking leg.
Abstract: Background:Muscle injury is the most common injury type in professional soccer players. Despite this, risk factors for common lower extremity injuries remain elusive.Purpose:To evaluate the effects of various player- and match-related risk factors on the occurrence of lower extremity muscle injury in male professional soccer.Study Design:Cohort study; Level of evidence, 2.Methods:Between 2001 and 2010, 26 soccer clubs (1401 players) from 10 European countries participated in the study. Individual player exposure and time loss muscle injuries in the lower extremity were registered prospectively by the club medical staffs during 9 consecutive seasons. Hazard ratios (HRs) were calculated for player-related factors from simple and multiple Cox regression, and odds ratios (ORs) were calculated for match-related variables from simple and multiple logistic regression, presented with 95% confidence intervals (CIs).Results:There were 2123 muscle injuries documented in the major lower extremity muscle groups: adduc...
TL;DR: In this paper, the authors explored the effects of national cultural practices on entrepreneurial behaviors by individuals, and used appropriate multi-level research designs to consider the effect of culture on different entrepreneurial behaviors such as entry and post-entry growth aspirations.
Abstract: Although national culture is an important regulator of entrepreneurship, there is a dearth of studies that (i) explore the effects of national cultural practices on entrepreneurial behaviors by individuals; (ii) use appropriate multi-level research designs; (iii) consider the effects of culture on different entrepreneurial behaviors such as entry and post-entry growth aspirations. We combined Global Entrepreneurship Monitor (GEM) and Global Leadership and Organizational Behavior Effectiveness (GLOBE) data from 42 countries for 2005-2008 to address these gaps using a multi-level design. We found societal institutional collectivism practices negatively associated with entrepreneurial entry but positively associated with entrepreneurial growth aspirations. Uncertainty avoidance practices were negatively associated with entry but not with growth aspirations, while performance orientation practices were positively associated with entry. Our analysis highlights the differential effects of cultural practices on entrepreneurial entry and growth aspirations and demonstrates the value of multi-level techniques in analyzing the effect of culture on entrepreneurship.
TL;DR: A confirmatory factor analysis was conducted on reported functions of NSSI, with the aim of validating Nock and Prinstein’s four-factor model on a Swedish community sample, resulting in a close to acceptable fit.
Abstract: Previous prevalence rates of non-suicidal self-injury (NSSI) in adolescents have varied considerably. In the present cross-sectional study, prevalence rates, characteristics and functions of NSSI were assessed in a large randomized community sample consisting of 3,060 (50.5 % female) Swedish adolescents aged 15–17 years. The suggested criteria for NSSI disorder in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition, (DSM-5) were used to assess prevalence rates with the aim of arriving at a more precise estimate. Out of the whole sample, 1,088 (35.6 %) adolescents (56.2 % female) reported at least one episode of NSSI during the last year, of which 205 (6.7 %) met suggested DSM-5 criteria for a potential NSSI disorder diagnosis. The NSSI disorder diagnosis was significantly more common in girls (11.1 % vs. 2.3 %, χ2 (1, N = 3046) = 94.08, p < 0.001, cOR = 5.43, 95 % CI [3.73, 7.90]). The NSSI disorder group consisted of significantly more smokers and drug users compared to adolescents with NSSI that did not meet DSM-5 criteria for NSSI disorder, and also differed concerning demographic variables. A confirmatory factor analysis (CFA) was conducted on reported functions of NSSI, with the aim of validating Nock and Prinstein’s (Journal of Consulting and Clinical Psychology 72:885–890, 2004, Journal of Abnormal Psychology 114:140–146, 2005) four-factor model on a Swedish community sample, resulting in a close to acceptable fit. A two-factor model (social and automatic reinforcement) resulted in a slightly better fit. The most frequently reported factors were positive and negative automatic reinforcement. A majority of functions were significantly more often reported by girls than boys. The implications of the suggested DSM-5 criteria and reported functions are discussed.
TL;DR: In this article, stress constraints are used together with an objective function that minimizes mass or maximizes stiffness, and in addition, the traditional stiffness based formulation is discussed for comparison.
Abstract: This paper develops and evaluates a method for handling stress constraints in topology optimization. The stress constraints are used together with an objective function that minimizes mass or maximizes stiffness, and in addition, the traditional stiffness based formulation is discussed for comparison. We use a clustering technique, where stresses for several stress evaluation points are clustered into groups using a modified P-norm to decrease the number of stress constraints and thus the computational cost. We give a detailed description of the formulations and the sensitivity analysis. This is done in a general manner, so that different element types and 2D as well as 3D structures can be treated. However, we restrict the numerical examples to 2D structures with bilinear quadrilateral elements. The three formulations and different approaches to stress constraints are compared using two well known test examples in topology optimization: the L-shaped beam and the MBB-beam. In contrast to some other papers on stress constrained topology optimization, we find that our formulation gives topologies that are significantly different from traditionally optimized designs, in that it actually manage to avoid stress concentrations. It can therefore be used to generate conceptual designs for industrial applications.
TL;DR: Investigation of pathways that linked students' basicmoral sensitivity, moral disengagement, and defender self-efficacy to different bystander behaviors in bullying situations indicated that compared with boys, girls expressed higher basic moral sensitivity in bullying, lower defender self -efficacy and moral diseng engagement in bullying.