Institution
Linköping University
Education•Linköping, Sweden•
About: Linköping University is a education organization based out in Linköping, Sweden. It is known for research contribution in the topics: Population & Health care. The organization has 15671 authors who have published 50013 publications receiving 1542189 citations.
Papers published on a yearly basis
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TL;DR: In this paper, a critical analysis of the literature of solutions offerings is presented, and a new conceptual framework is provided, incorporating dimensions that can distinguish be different from different solutions offerings.
Abstract: Purpose – The purpose of this paper is to offer a critical analysis of the literature of solutions offerings; to provide a new conceptual framework, incorporating dimensions that can distinguish be ...
262 citations
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TL;DR: In this article, five different recursive identification methods are compared, namely recursive versions of the least square method, the instrumental variable method, generalized least squares method, extended least squares, and the maximum likelihood method.
262 citations
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TL;DR: It is found that one-fourth of the world's population is infected with latent tuberculosis, and enhanced efforts are needed targeting the large pool of latently infected individuals, as this constitutes an enormous source of potential active tuberculosis.
Abstract: In 1999, the World Health Organization (WHO) estimated that one-third of the world9s population had latent tuberculosis infection (LTBI), which was recently updated to one-fourth. However, this is still based on controversial assumptions in combination with tuberculin skin test (TST) surveys. Interferon-γ release assays (IGRAs) with a higher specificity than TST have since been widely implemented, but never used to estimate the global LTBI prevalence. We conducted a systematic review and meta-analysis of LTBI estimates based on both IGRA and TST results published between 2005 and 2018. Regional and global estimates of LTBI prevalence were calculated. Stratification was performed for low, intermediate and high TB incidence countries and a pooled estimate for each area was calculated using a random effects model. Among 3280 studies screened, we included 88 studies from 36 countries with 41 IGRA (n=67 167) and 67 TST estimates (n=284 644). The global prevalence of LTBI was 24.8% (95% CI 19.7–30.0%) and 21.2% (95% CI 17.9–24.4%), based on IGRA and a 10-mm TST cut-off, respectively. The prevalence estimates correlated well to WHO incidence rates (Rs=0.70, p In the first study of the global prevalence of LTBI derived from both IGRA and TST surveys, we found that one-fourth of the world9s population is infected. This is of relevance, as both tests, although imperfect, are used to identify individuals eligible for preventive therapy. Enhanced efforts are needed targeting the large pool of latently infected individuals, as this constitutes an enormous source of potential active tuberculosis.
262 citations
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TL;DR: In this article, the authors develop and extend the notion of "creative accumulation" as a way of conceptualizing the innovating capacity of the incumbents that appear to master such turbulence, arguing that firms to handle a triple challenge of simultaneously fine-tuning and evolving existing technologies at a rapid pace, acquiring and developing new technologies and resources and integrating novel and existing knowledge into superior products and solutions.
262 citations
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VU University Medical Center1, Maastricht University2, United States Department of Veterans Affairs3, University of Gothenburg4, UCL Institute of Neurology5, Lund University6, Karolinska University Hospital7, Linköping University8, Aristotle University of Thessaloniki9, University of Perugia10, University of Eastern Finland11, Pierre-and-Marie-Curie University12, New York University13, Heidelberg University14, Stavanger University Hospital15
TL;DR: In this paper, the most useful definition of the "cerebrospinal fluid Alzheimer profile," based on amyloid-s 1-42 (Aβ 42 ), total tau, and phosphorylated tau (p-tau), for diagnosis and prognosis of Alzheimer's disease (AD) was identified.
Abstract: Background We aimed to identify the most useful definition of the "cerebrospinal fluid Alzheimer profile," based on amyloid-s 1-42 (Aβ 42 ), total tau, and phosphorylated tau (p-tau), for diagnosis and prognosis of Alzheimer's disease (AD). Methods We constructed eight Alzheimer profiles with previously published combinations, including regression formulas and simple ratios. We compared their diagnostic accuracy and ability to predict dementia due to AD in 1385 patients from the Amsterdam Dementia Cohort. Results were validated in an independent cohort (n = 1442). Results Combinations outperformed individual biomarkers. Based on the sensitivity of the best performing regression formulas, cutoffs were chosen at 0.52 for the tau/Aβ 42 ratio and 0.08 for the p-tau/Aβ 42 ratio. Ratios performed similar to formulas (sensitivity, 91%–93%; specificity, 81%–84%). The same combinations best predicted cognitive decline in mild cognitive impairment patients. Validation confirmed these results, especially regarding the tau/Aβ 42 ratio. Conclusions A tau/Aβ 42 ratio of >0.52 constitutes a robust cerebrospinal fluid Alzheimer profile. We recommend using this ratio to combine biomarkers.
262 citations
Authors
Showing all 15844 results
Name | H-index | Papers | Citations |
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Rui Zhang | 151 | 2625 | 107917 |
Jun Lu | 135 | 1526 | 99767 |
Jean-Luc Brédas | 134 | 1026 | 85803 |
Lars Wallentin | 124 | 767 | 61020 |
S. Shankar Sastry | 122 | 858 | 86155 |
Gerhard Andersson | 118 | 902 | 49159 |
Olle Inganäs | 113 | 627 | 50562 |
Antonio Facchetti | 111 | 602 | 51885 |
Ray H. Baughman | 110 | 616 | 60009 |
Michel W. Barsoum | 106 | 543 | 60539 |
Louis J. Ignarro | 106 | 335 | 46008 |
Per Björntorp | 105 | 386 | 40321 |
Jan Lubinski | 103 | 689 | 52120 |
Magnus Johannesson | 102 | 342 | 40776 |
Barbara Riegel | 101 | 507 | 77674 |