Institution
Oregon State University
Education•Corvallis, Oregon, United States•
About: Oregon State University is a education organization based out in Corvallis, Oregon, United States. It is known for research contribution in the topics: Population & Gene. The organization has 28192 authors who have published 64044 publications receiving 2634108 citations. The organization is also known as: Oregon Agricultural College & OSU.
Topics: Population, Gene, Context (language use), Climate change, Soil water
Papers published on a yearly basis
Papers
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Karolinska University Hospital1, Karolinska Institutet2, Hospital of the University of Pennsylvania3, Great Ormond Street Hospital4, Brigham and Women's Hospital5, University of Kansas6, University of Alabama7, Mayo Clinic8, University of Pittsburgh9, Central Manchester University Hospitals NHS Foundation Trust10, University of Liverpool11, University of Debrecen12, University of Toronto13, University of Guadalajara14, University of Cambridge15, University of Tsukuba16, United States Department of Health and Human Services17, Tokyo Medical and Dental University18, Oregon State University19, Dalhousie University20, Peking University21, Duke University22, Oslo University Hospital23, New Generation University College24, Charles University in Prague25, National Institutes of Health26
TL;DR: New classification criteria for IIM have been endorsed by international rheumatology, dermatology, neurology and paediatric groups, and have been partially validated and generally perform better than existing criteria.
Abstract: Objective To develop and validate new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) and their major subgroups. Methods Candidate variables were assembled from published criteria and expert opinion using consensus methodology. Data were collected from 47 rheumatology, dermatology, neurology and paediatric clinics worldwide. Several statistical methods were used to derive the classification criteria. Results Based on data from 976 IIM patients (74% adults; 26% children) and 624 non-IIM patients with mimicking conditions (82% adults; 18% children), new criteria were derived. Each item is assigned a weighted score. The total score corresponds to a probability of having IIM. Subclassification is performed using a classification tree. A probability cut-off of 55%, corresponding to a score of 5.5 (6.7 with muscle biopsy) ‘probable IIM’, had best sensitivity/specificity (87%/82% without biopsies, 93%/88% with biopsies) and is recommended as a minimum to classify a patient as having IIM. A probability of ≥90%, corresponding to a score of ≥7.5 (≥8.7 with muscle biopsy), corresponds to ‘definite IIM’. A probability of Conclusions The European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for IIM have been endorsed by international rheumatology, dermatology, neurology and paediatric groups. They employ easily accessible and operationally defined elements, and have been partially validated. They allow classification of ‘definite’, ‘probable’ and ‘possible’ IIM, in addition to the major subgroups of IIM, including juvenile IIM. They generally perform better than existing criteria.
754 citations
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TL;DR: Divalent calcium ions greatly enhance natural organic matter fouling by complexation and subsequent formation of intermolecular bridges among organic foulant molecules and a remarkable correlation was obtained between the measured adhesion forces and the fouling and cleaning behavior of the membrane under various solution chemistries.
Abstract: Fouling and subsequent chemical cleaning of nanofiltration (NF) membranes used in water quality control applications are often inevitable. To unravel the mechanisms of organic fouling and chemical cleaning, it is critical to understand the foulant-membrane, foulant-foulant, and foulant-cleaning agent interactions at the molecular level. In this study, the adhesion forces between the foulant and the membrane surface and between the bulk foulant and the fouling layer were determined by atomic force microscopy (AFM). A carboxylate modified AFM colloid probe was used as a surrogate for humic acid, the major organic foulant in natural waters. The interfacial force data were combined with the NF membrane water flux measurements to elucidate the mechanisms of organic fouling and chemical cleaning. A remarkable correlation was obtained between the measured adhesion forces and the fouling and cleaning behavior of the membrane under various solution chemistries. The AFM measurements further confirmed that divalent calcium ions greatly enhance natural organic matter fouling by complexation and subsequent formation of intermolecular bridges among organic foulant molecules. Efficient chemical cleaning was achieved only when the calcium ion bridging was eliminated as a result of the interaction between the chemical cleaning agent and the fouling layer. The cleaning efficiency was highly dependent on solution pH and the concentration of the chemical cleaning agent.
750 citations
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TL;DR: Mechanism-based effects of vitamin C and E supplementation on biomarkers and on clinical outcomes from randomized, placebo-controlled trials are emphasized in this review.
748 citations
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TL;DR: The results suggest that even a few generations of domestication may have negative effects on natural reproduction in the wild and that the repeated use of captive-reared parents to supplement wild populations should be carefully reconsidered.
Abstract: :plications for our ability to sample and identify all the ecologically relevant members of microbial communities in other high-diversity habitats, such as soils (22), microbial mats (23), and communities where low-abundance taxa may play crucial roles, such as the human microbiome. It provides a comparative population structure analysis with statistically significant descriptions of diversity and relative abundance of microbial populations. These large estimates of phylogenetic diversity at every taxonomic level present a challenge to large-scale microbial community genomic surveys. Metagenomic studies seek to inventory the full range of metabolic capabilities that define ecosystem function or to determine their context within assembled genomic scaffolds. Our results suggest that even the largest of published metagenomic investigations inadequately represent the full extent of microbial diversity, as they survey only the most highly abundant taxa (11).
746 citations
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University of Idaho1, University of British Columbia2, Harvard University3, University of California, Santa Barbara4, University of California, Berkeley5, University of Georgia6, Humboldt State University7, University of Minnesota8, Dartmouth College9, Clarkson University10, Yale University11, Imperial College London12, University of Missouri–St. Louis13, Swiss Federal Institute of Aquatic Science and Technology14, University of Bern15, National Evolutionary Synthesis Center16, Oregon State University17, Pontificia Universidad Católica del Ecuador18, Simon Fraser University19
TL;DR: It is suggested that the classical model of adaptive radiation, where morphological evolution is initially rapid and slows through time, may be rare in comparative data.
Abstract: George Gaylord Simpson famously postulated that much of life's diversity originated as adaptive radiations-more or less simultaneous divergences of numerous lines from a single ancestral adaptive type. However, identifying adaptive radiations has proven difficult due to a lack of broad-scale comparative datasets. Here, we use phylogenetic comparative data on body size and shape in a diversity of animal clades to test a key model of adaptive radiation, in which initially rapid morphological evolution is followed by relative stasis. We compared the fit of this model to both single selective peak and random walk models. We found little support for the early-burst model of adaptive radiation, whereas both other models, particularly that of selective peaks, were commonly supported. In addition, we found that the net rate of morphological evolution varied inversely with clade age. The youngest clades appear to evolve most rapidly because long-term change typically does not attain the amount of divergence predicted from rates measured over short time scales. Across our entire analysis, the dominant pattern was one of constraints shaping evolution continually through time rather than rapid evolution followed by stasis. We suggest that the classical model of adaptive radiation, where morphological evolution is initially rapid and slows through time, may be rare in comparative data.
744 citations
Authors
Showing all 28447 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert Stone | 160 | 1756 | 167901 |
Menachem Elimelech | 157 | 547 | 95285 |
Thomas J. Smith | 140 | 1775 | 113919 |
Harold A. Mooney | 135 | 450 | 100404 |
Jerry M. Melillo | 134 | 383 | 68894 |
John F. Thompson | 132 | 1420 | 95894 |
Thomas N. Williams | 132 | 1145 | 95109 |
Peter M. Vitousek | 127 | 352 | 96184 |
Steven W. Running | 126 | 355 | 76265 |
Vincenzo Di Marzo | 126 | 659 | 60240 |
J. D. Hansen | 122 | 975 | 76198 |
Peter Molnar | 118 | 446 | 53480 |
Michael R. Hoffmann | 109 | 500 | 63474 |
David Pollard | 108 | 438 | 39550 |
David J. Hill | 107 | 1364 | 57746 |