University College Cork

About: University College Cork is a education organization based out in Cork, Ireland. It is known for research contribution in the topics: Population & Context (language use). The organization has 12056 authors who have published 28452 publications receiving 958414 citations. The organization is also known as: Coláiste na hOllscoile Corcaigh & National University of Ireland, Cork.

Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment.

Abstract: Several protein families control intracellular transport processes in eukaryotic cells. Here, we show that the Rab11 GTPase effector protein Rab11-FIP3 (henceforth, FIP3) directly interacts with the dynein light intermediate chain 1 (DLIC-1, gene symbol DYNC1LI1) subunit of the cytoplasmic dynein 1 motor protein complex. We show that Rab11a, FIP3 and DLIC-1 form a ternary complex and that DLIC-1 colocalises with endogenous FIP3 and Rab11a in A431 cells. We demonstrate that association between FIP3 and DLIC-1 at the cell periphery precedes minus-end-directed microtubule-based transport, that FIP3 recruits DLIC-1 onto membranes, and that knockdown of DLIC-1 inhibits pericentrosomal accumulation of key endosomal-recycling compartment (ERC) proteins. In addition, we demonstrate that expression of a DLIC-1-binding truncation mutant of FIP3 disrupts the ability of ERC proteins to accumulate pericentrosomally. On the basis of these and other data, we propose that FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport of material from peripheral sorting endosomes to the centrally located ERC.

The effect of moderate gestational alcohol consumption during pregnancy on speech and language outcomes in children: a systematic review

Abstract: Background Consensus has not been reached on safe alcohol consumption recommendations during pregnancy. The National Institutes for Care and Health Excellence (NICE) in the UK suggest that one to two drinks not more than twice per week is safe. However, the speech and language effects of even low levels of alcohol use among offspring are unknown. The aim of this study was to review systematically the evidence on studies of the effect of low to moderate levels of alcohol consumption during pregnancy (up to 70 grams of alcohol per week) compared to abstinence on speech and language outcomes in children.

Microbiota-Gut-Brain Axis: New Therapeutic Opportunities

Abstract: The traditional fields of pharmacology and toxicology are beginning to consider the substantial impact our gut microbiota has on host physiology. The microbiota-gut-brain axis is emerging as a particular area of interest and a potential new therapeutic target for effective treatment of central nervous system disorders, in addition to being a potential cause of drug side effects. Microbiota-gut-brain axis signaling can occur via several pathways, including via the immune system, recruitment of host neurochemical signaling, direct enteric nervous system routes and the vagus nerve, and the production of bacterial metabolites. Altered gut microbial profiles have been described in several psychiatric and neurological disorders. Psychobiotics, live biotherapeutics or substances whose beneficial effects on the brain are bacterially mediated, are currently being investigated as direct and/or adjunctive therapies for psychiatric and neurodevelopmental disorders and possibly for neurodegenerative disease, and they may emerge as new therapeutic options in the clinical management of brain disorders.

Integrating short term variations of the power system into integrated energy system models: A methodological review

Abstract: It is anticipated that the decarbonisation of the entire energy system will require the introduction of large shares of variable renewable electricity generation into the power system. Long term integrated energy systems models are useful in improving our understanding of decarbonisation but they struggle to take account of short term variations in the power system associated with increased variable renewable energy penetration. This can oversimplify the ability of power systems to accommodate variable renewables and result in mistaken signals regarding the levels of flexibility required in power systems. Capturing power system impacts of variability within integrated energy system models is challenging due to temporal and technical simplifying assumptions needed to make such models computationally manageable. This paper addresses a gap in the literature by reviewing prominent methodologies that have been applied to address this challenge and the advantages & limitations of each. The methods include soft linking between integrated energy systems models and power systems models and improving the temporal and technical representation of power systems within integrated energy systems models. Each methodology covered approaches the integration of short term variations and assesses the flexibility of the system differently. The strengths, limitations, and applicability of these different methodologies are analysed. This review allows users of integrated energy systems models to select a methodology (or combination of methodologies) to suit their needs. In addition, the analysis identifies remaining gaps and shortcomings.