University College Cork

About: University College Cork is a education organization based out in Cork, Ireland. It is known for research contribution in the topics: Population & Context (language use). The organization has 12056 authors who have published 28452 publications receiving 958414 citations. The organization is also known as: Coláiste na hOllscoile Corcaigh & National University of Ireland, Cork.

Bacteriocin Production: a Probiotic Trait?

Abstract: Bacteriocins are an abundant and diverse group of ribosomally synthesized antimicrobial peptides produced by bacteria and archaea. Traditionally, bacteriocin production has been considered an important trait in the selection of probiotic strains, but until recently, few studies have definitively demonstrated the impact of bacteriocin production on the ability of a strain to compete within complex microbial communities and/or positively influence the health of the host. Although research in this area is still in its infancy, there is intriguing evidence to suggest that bacteriocins may function in a number of ways within the gastrointestinal tract. Bacteriocins may facilitate the introduction of a producer into an established niche, directly inhibit the invasion of competing strains or pathogens, or modulate the composition of the microbiota and influence the host immune system. Here we review the role of bacteriocin production in complex microbial communities and their potential to enhance human health.

Techno-economic review of existing and new pumped hydro energy storage plant

Abstract: There has been a renewed commercial and technical interest in pumped hydro energy storage (PHES) recently with the advent of increased variable renewable energy generation and the development of liberalized electricity markets. During the next 8 years over 7 GW of PHES capacity will be added to the European network while projects are also planned in the USA and Japan. This paper provides a review of existing and proposed PHES plant and discusses the technical and economic drivers for these developments. Current trends for new PHES development generally show that developers operating in liberalized markets are tending to repower, enhance projects or build ‘pump-back’ PHES rather than traditional ‘pure pumped storage’. Capital costs per kW for proposed PHES in the review region range between €470/kW and €2170/kW, however these costs are highly site and project specific. An emergence has also been observed in recent PHES developments of the use of variable speed technology. This technology, while incurring slightly higher capital costs, offers a greater range of operational flexibility and efficiency over conventional PHES. This paper has primarily been prompted by a lack of detailed information on PHES facilities worldwide and reviews current developments in the context of market and generation mix changes. The most recent large scale review of PHES faculties was undertaken by the American Society of Civil Engineers Hydro Power Task Committee on Pumped Storage in 1996. In the absence of data in the literature on new PHES plant development, this review draws primarily on publicly available information from utilities, government bodies and electricity regulators. In the same context this study is limited to a review region of the European Union, Japan and the United States as information on developments outside these areas is difficult to procure. This paper also gives a review of locations and proposed timelines for new PHES development and provides a thorough up-to-date overview of the development trends of this technology.

Hydrogen peroxide: a Jekyll and Hyde signalling molecule

Abstract: Reactive oxygen species (ROS) are a group of molecules produced in the cell through metabolism of oxygen. Endogenous ROS such as hydrogen peroxide (H₂O₂) have long been recognised as destructive molecules. The well-established roles they have in the phagosome and genomic instability has led to the characterisation of these molecules as non-specific agents of destruction. Interestingly, there is a growing body of literature suggesting a less sinister role for this Jekyll and Hyde molecule. It is now evident that at lower physiological levels, H₂O₂ can act as a classical intracellular signalling molecule regulating kinase-driven pathways. The newly discovered biological functions attributed to ROS include proliferation, migration, anoikis, survival and autophagy. Furthermore, recent advances in detection and quantification of ROS-family members have revealed that the diverse functions of ROS can be determined by the subcellular source, location and duration of these molecules within the cell. In light of this confounding paradox, we will examine the factors and circumstances that determine whether H₂O₂ acts in a pro-survival or deleterious manner.