Institution
University of Duisburg-Essen
Education•Essen, Nordrhein-Westfalen, Germany•
About: University of Duisburg-Essen is a education organization based out in Essen, Nordrhein-Westfalen, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 16072 authors who have published 39972 publications receiving 1109199 citations.
Papers published on a yearly basis
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Albany Medical College1, University of Duisburg-Essen2, Maastricht University3, University of Colorado Denver4, University of California, San Francisco5, Cleveland Clinic6, University of Paris7, University of Illinois at Chicago8, Ohio State University9, Icahn School of Medicine at Mount Sinai10, University of Cincinnati11, Nippon Medical School12, University of Pennsylvania13, Tongji University14, University of Freiburg15
TL;DR: An instrument was developed by expert opinion that may be useful for the clinician and researcher in establishing criteria for sarcoidosis organ involvement.
Abstract: Introduction: A Case Control Etiology of Sarcoidosis Study (ACCESS) sarcoidosis organ assessment instrument has been used for more than a decade to establish uniform standards for the probability of sarcoidosis organ involvement. The ACCESS instrument has become increasingly outdated as new technologies have been developed. Furthermore, the ACCESS instrument failed to address all possible organs involved with sarcoidosis. For these reasons, the World Association of Sarcoidosis and Other Granulomatous Diseases (WASOG) developed a new sarcoidosis organ assessment instrument. Methods: Clinical sarcoidosis experts assessed various clinical manifestations for the probability of sarcoidosis organ involvement. Two criteria were required to apply this assessment: 1) histologic evidence of granulomatous inflammation of unknown cause in an organ that was not being assessed; 2) the clinical manifestation being addressed required that alternative causes other than sarcoidosis had been reasonably excluded. Clinical manifestations were assessed as either: a) highly probable: likelihood of sarcoidosis causing this manifestation of at least 90%.; b) probable: likelihood of sarcoidosis causing this manifestation of between 50 and 90%; c) possible: likelihood of sarcoidosis causing this manifestation of less than 50%. The sarcoidosis experts voted on the likelihood of sarcoidosis causing each manifestation using Delphi study methodology where at least 70% agreement of the experts was needed for consensus. Results: Various clinical manifestations were classified as highly probable, at least probable, possible, or indeterminate when no consensus could be reached. Conclusion: An instrument was developed by expert opinion that may be useful for the clinician and researcher in establishing criteria for sarcoidosis organ involvement.
348 citations
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University of Pennsylvania1, Erasmus University Rotterdam2, University of Bristol3, University of Duisburg-Essen4, Pasteur Institute5, University of Western Australia6, University College London7, University of Copenhagen8, Imperial College London9, University of Southern California10, University of Helsinki11, University of Marburg12, VU University Amsterdam13, University of Oxford14, University of Tartu15, University College Dublin16, Queen's University Belfast17, University of Zaragoza18, University of Oulu19, University of Turku20, University of Tampere21, Wellcome Trust Sanger Institute22, Pompeu Fabra University23, Harvard University24, University of Cambridge25, McMaster University26
TL;DR: A North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases and 8,318 controls of European ancestry observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 and within HOXB5 at 17q21, which yielded directionally consistent associations.
Abstract: Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10(-6) in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10(-9); odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10(-9); OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI(1).
347 citations
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TL;DR: In this article, a human serum albumin (HSA) was modified by succinic anhydride (HSAsuc) to generate additional carboxyl groups on the protein surface, which showed a 3-fold decreased binding affinity toward the nanoparticles.
Abstract: Recent studies have firmly established that cellular uptake of nanoparticles is strongly affected by the presence and the physicochemical properties of a protein adsorption layer around these nanoparticles. Here, we have modified human serum albumin (HSA), a serum protein often used in model studies of protein adsorption onto nanoparticles, to alter its surface charge distribution and investigated the consequences for protein corona formation around small (radius ∼5 nm), dihydrolipoic acid-coated quantum dots (DHLA-QDs) by using fluorescence correlation spectroscopy. HSA modified by succinic anhydride (HSAsuc) to generate additional carboxyl groups on the protein surface showed a 3-fold decreased binding affinity toward the nanoparticles. A 1000-fold enhanced affinity was observed for HSA modified by ethylenediamine (HSAam) to increase the number of amino functions on the protein surface. Remarkably, HSAsuc formed a much thicker protein adsorption layer (8.1 nm) than native HSA (3.3 nm), indicating that i...
345 citations
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National Technical University of Athens1, University of Manchester2, University of Chile3, Iowa State University4, University of Waterloo5, University of Duisburg-Essen6, University of Hong Kong7, University of Michigan8, Hydro-Québec9, Imperial College London10, Tufts University11, Arizona State University12
TL;DR: This paper based on an IEEE PES report summarizes the major results of the work of the Task Force and presents extended definitions and classification of power system stability.
Abstract: Since the publication of the original paper on power system stability definitions in 2004, the dynamic behavior of power systems has gradually changed due to the increasing penetration of converter interfaced generation technologies, loads, and transmission devices. In recognition of this change, a Task Force was established in 2016 to re-examine and extend, where appropriate, the classic definitions and classifications of the basic stability terms to incorporate the effects of fast-response power electronic devices. This paper based on an IEEE PES report summarizes the major results of the work of the Task Force and presents extended definitions and classification of power system stability.
345 citations
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TL;DR: An automated biogeochemical microcosm system allowing the control of redox potential (E H ) in soil suspensions was used to assess the effect of E H on the mobility of cadmium (Cd), copper (Cu), nickel (Ni), zinc (Zn), iron (Fe), and manganese (Mn) as well as on the methylation of arsenic (As) and antimony (Sb) in a contaminated and slightly acidic floodplain soil as discussed by the authors.
345 citations
Authors
Showing all 16364 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rui Zhang | 151 | 2625 | 107917 |
Olli T. Raitakari | 142 | 1232 | 103487 |
Anders Hamsten | 139 | 611 | 88144 |
Robert Huber | 139 | 671 | 73557 |
Christopher T. Walsh | 139 | 819 | 74314 |
Patrick D. McGorry | 137 | 1097 | 72092 |
Stanley Nattel | 132 | 778 | 65700 |
Luis M. Liz-Marzán | 132 | 616 | 61684 |
Dirk Schadendorf | 127 | 1017 | 105777 |
William Wijns | 127 | 752 | 95517 |
Raimund Erbel | 125 | 1364 | 74179 |
Khalil Amine | 118 | 652 | 50111 |
Hans-Christoph Diener | 118 | 1025 | 91710 |
Bruce A.J. Ponder | 116 | 403 | 54796 |
Andre Franke | 115 | 682 | 55481 |