Institution
University of Gothenburg
Education•Gothenburg, Sweden•
About: University of Gothenburg is a education organization based out in Gothenburg, Sweden. It is known for research contribution in the topics: Population & Health care. The organization has 23855 authors who have published 65241 publications receiving 2606327 citations. The organization is also known as: Göteborg University & Gothenburg University.
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TL;DR: This review has brought together available evidence from human and experimental animal studies to describe the complex changes in brain structure and function that occur as a consequence of Fetal growth restriction.
Abstract: Fetal growth restriction (FGR) is a significant complication of pregnancy describing a fetus that does not grow to full potential due to pathological compromise. FGR affects 3-9% of pregnancies in high-income countries, and is a leading cause of perinatal mortality and morbidity. Placental insufficiency is the principal cause of FGR, resulting in chronic fetal hypoxia. This hypoxia induces a fetal adaptive response of cardiac output redistribution to favour vital organs, including the brain, and is in consequence called brain sparing. Despite this, it is now apparent that brain sparing does not ensure normal brain development in growth-restricted fetuses. In this review we have brought together available evidence from human and experimental animal studies to describe the complex changes in brain structure and function that occur as a consequence of FGR. In both humans and animals, neurodevelopmental outcomes are influenced by the timing of the onset of FGR, the severity of FGR, and gestational age at delivery. FGR is broadly associated with reduced total brain volume and altered cortical volume and structure, decreased total number of cells and myelination deficits. Brain connectivity is also impaired, evidenced by neuronal migration deficits, reduced dendritic processes, and less efficient networks with decreased long-range connections. Subsequent to these structural alterations, short- and long-term functional consequences have been described in school children who had FGR, most commonly including problems in motor skills, cognition, memory and neuropsychological dysfunctions.
347 citations
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TL;DR: In this article, a general model of the evolution of the multinational business enterprise (MBE), from early steps abroad to being a global firm, is presented, anchored in process ontology, which is useful in conducting longitudinal empirical studies.
Abstract: The original Uppsala model that was published in 1977 explains the internationalization process of firms. We have further developed the model several times in the intervening years. The present article is our latest effort: a general model of the evolution of the multinational business enterprise (MBE), from early steps abroad to being a global firm. The updated, augmented model explains MBE evolution in general, not only characteristics of the internationalization process in a narrow sense. We believe that the newest iteration, anchored in process ontology, will be useful in conducting longitudinal empirical studies.
347 citations
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TL;DR: This work presents methods to determine the limit of detection (LoD) and thelimit of quantification (LoQ) as applicable to qPCR, based on standard statistical methods as recommended by regulatory bodies adapted toqPCR and complemented with a novel approach to estimate the precision of LoD.
347 citations
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TL;DR: In this paper, a rapid carbamate extraction method with pyrrolidinedithiocarbamate (PDI) and diethyldithionic carbamate (DHC) was described for the simultaneous determination of Cd, Co, Cu, Fe, Ni, Pb and Zn in sea water by atomic absorption spectrometry with a graphite atomizer.
346 citations
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Newcastle University1, Children's Hospital of Philadelphia2, Cincinnati Children's Hospital Medical Center3, University of Kansas4, University of Western Ontario5, University of Milan6, Washington University in St. Louis7, University of Minnesota8, Nationwide Children's Hospital9, Katholieke Universiteit Leuven10, University of Sydney11, Catholic University of the Sacred Heart12, Oregon Health & Science University13, Royal Children's Hospital14, University of Gothenburg15, University of Iowa16, University of Pennsylvania17, Boston Children's Hospital18, University of Utah19
TL;DR: As the first investigational new drug targeting the underlying cause of nm‐dystrophinopathy, ataluren offers promise as a treatment for this orphan genetic disorder with high unmet medical need.
Abstract: Introduction: Dystrophinopathy is a rare, severe muscle disorder, and nonsense mutations are found in 13% of cases. Ataluren was developed to enable ribosomal readthrough of premature stop codons in nonsense mutation (nm) genetic disorders. Methods: Randomized, double-blind, placebo-controlled study; males ≥5 years with nm-dystrophinopathy received study drug orally 3 times daily, ataluren 10, 10, 20 mg/kg (N = 57); ataluren 20, 20, 40 mg/kg (N = 60); or placebo (N = 57) for 48 weeks. The primary endpoint was change in 6-Minute Walk Distance (6MWD) at Week 48. Results: Ataluren was generally well tolerated. The primary endpoint favored ataluren 10, 10, 20 mg/kg versus placebo; the week 48 6MWD Δ = 31.3 meters, post hoc P = 0.056. Secondary endpoints (timed function tests) showed meaningful differences between ataluren 10, 10, 20 mg/kg, and placebo. Conclusions: As the first investigational new drug targeting the underlying cause of nm-dystrophinopathy, ataluren offers promise as a treatment for this orphan genetic disorder with high unmet medical need. Muscle Nerve 50: 477–487, 2014
345 citations
Authors
Showing all 24120 results
Name | H-index | Papers | Citations |
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Peter J. Barnes | 194 | 1530 | 166618 |
Luigi Ferrucci | 193 | 1601 | 181199 |
Richard H. Friend | 169 | 1182 | 140032 |
Napoleone Ferrara | 167 | 494 | 140647 |
Timothy A. Springer | 167 | 669 | 122421 |
Anders Björklund | 165 | 769 | 84268 |
Hua Zhang | 163 | 1503 | 116769 |
Kaj Blennow | 160 | 1845 | 116237 |
Leif Groop | 158 | 919 | 136056 |
Tomas Hökfelt | 158 | 1033 | 95979 |
Johan G. Eriksson | 156 | 1257 | 123325 |
Naveed Sattar | 155 | 1326 | 116368 |
Paul Elliott | 153 | 773 | 103839 |
Claude Bouchard | 153 | 1076 | 115307 |
Hakon Hakonarson | 152 | 968 | 101604 |