Institution
University of Gothenburg
Education•Gothenburg, Sweden•
About: University of Gothenburg is a education organization based out in Gothenburg, Sweden. It is known for research contribution in the topics: Population & Health care. The organization has 23855 authors who have published 65241 publications receiving 2606327 citations. The organization is also known as: Göteborg University & Gothenburg University.
Papers published on a yearly basis
Papers
More filters
University of Amsterdam1, Ghent University2, Imperial College London3, Charité4, University of Montpellier5, Medical University of Silesia6, Karolinska Institutet7, Umeå University8, Uppsala University9, Jagiellonian University10, University of Düsseldorf11, Medical University of Łódź12, Odense University Hospital13, University of Gothenburg14, University of Southampton15, Children's Hospital of Philadelphia16
TL;DR: This data indicates that rhinosinusitis in Europe is an underestimated disease, and the number of patients diagnosed with the disease and the severity of the disease should be increased.
Abstract: Background: Chronic rhinosinusitis (CRS) is a common health problem, with significant medical costs and impact on general health. Even so, prevalence figures for Europe are unavailable. In this st ...
812 citations
Genentech1, University of Gothenburg2, Royal Children's Hospital3, Eli Lilly and Company4, Aarhus University5, Boston Children's Hospital6, University of North Carolina at Chapel Hill7, University of Southern California8, Hokkaido University9, University of Turin10, Stanford University11, Garvan Institute of Medical Research12, Novo Nordisk13, National Scientific and Technical Research Council14, Ferring Pharmaceuticals15, Pfizer16, Food and Drug Administration17, University of Bern18, Emory University19, University of Tübingen20, Medical Research Council21, Oregon Health & Science University22, University of Tennessee Health Science Center23, Yeshiva University24, University of Pisa25, Royal London Hospital26, Ludwig Maximilian University of Munich27, University of Virginia28, Kaplan Medical Center29
810 citations
Katholieke Universiteit Leuven1, University of Bergen2, National and Kapodistrian University of Athens3, University of Brescia4, University of Gothenburg5, University of Padua6, Ludwig Maximilian University of Munich7, University of Pavia8, University of Oslo9, Uppsala University10, Aristotle University of Thessaloniki11, Sheba Medical Center12, University of Basel13, Children's National Medical Center14, University College London15, University of L'Aquila16
TL;DR: A consensus document from the Study Group of Sports Cardiology and the Working Group of Cardiac Rehabilitation and Exercise Physiology of the European Society of Cardiology has been published in this paper.
Abstract: A consensus document from the Study Group of Sports Cardiology of the Working Group of Cardiac Rehabilitation and Exercise Physiology and the Working Group of Myocardial and Pericardial Diseases of the European Society of Cardiology.
807 citations
TL;DR: Patients with type 2 diabetes who had five risk‐factor variables within the target ranges appeared to have little or no excess risk of death, myocardial infarction, or stroke, as compared with the general population.
Abstract: Background Patients with diabetes are at higher risk for death and cardiovascular outcomes than the general population. We investigated whether the excess risk of death and cardiovascular ...
806 citations
TL;DR: It is demonstrated that the therapeutic value of VSG does not result from mechanical restriction imposed by a smaller stomach, rather, VSG is associated with increased circulating bile acids, and associated changes to gut microbial communities, which point to bile acid and FXR signalling as an important molecular underpinning for the beneficial effects of this weight-loss surgery.
Abstract: Bariatric surgical procedures, such as vertical sleeve gastrectomy (VSG), are at present the most effective therapy for the treatment of obesity, and are associated with considerable improvements in co-morbidities, including type-2 diabetes mellitus. The underlying molecular mechanisms contributing to these benefits remain largely undetermined, despite offering the potential to reveal new targets for therapeutic intervention. Substantial changes in circulating total bile acids are known to occur after VSG. Moreover, bile acids are known to regulate metabolism by binding to the nuclear receptor FXR (farsenoid-X receptor, also known as NR1H4). We therefore examined the results of VSG surgery applied to mice with diet-induced obesity and targeted genetic disruption of FXR. Here we demonstrate that the therapeutic value of VSG does not result from mechanical restriction imposed by a smaller stomach. Rather, VSG is associated with increased circulating bile acids, and associated changes to gut microbial communities. Moreover, in the absence of FXR, the ability of VSG to reduce body weight and improve glucose tolerance is substantially reduced. These results point to bile acids and FXR signalling as an important molecular underpinning for the beneficial effects of this weight-loss surgery. Bariatric surgical procedures, such as vertical sleeve gastrectomy (VSG), are the most effective therapy for the treatment of obesity; now bile acids, and the presence of the nuclear bile acid receptor FXR, are shown to underpin the mechanism of VSG action, and the ability of VSG to reduce body weight and improve glucose tolerance is substantially reduced if FXR is absent. The use and misuse of invasive surgery to control obesity and related conditions is much debated. Whatever its merits, the associated costs and risks mean that it is inappropriate in many cases. This study challenges the notion that such surgery elicits weight loss solely by making it physically difficult to consume or absorb calories, and raises the prospect that it may be possible to develop therapies that achieve the same ends without the need for a scalpel. Vertical sleeve gastrectomy (VSG), in which some 80% of the stomach is removed to create a gastric 'sleeve' contiguous with the oesophagus and duodenum, is known to induce loss of body weight and fat mass, and improves glucose tolerance in humans and rodents. Randy Seeley and colleagues show here that the therapeutic effect of VSG in mice arises not from the mechanical restrictions of a smaller stomach but from the associated increase in the levels of circulating bile acids and changes to gut microbial communities. Moreover, in the absence of nuclear bile acid receptor FXR, the ability of VSG to reduce body weight and improve glucose tolerance is substantially reduced.
805 citations
Authors
Showing all 24120 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Peter J. Barnes | 194 | 1530 | 166618 |
| Luigi Ferrucci | 193 | 1601 | 181199 |
| Richard H. Friend | 169 | 1182 | 140032 |
| Napoleone Ferrara | 167 | 494 | 140647 |
| Timothy A. Springer | 167 | 669 | 122421 |
| Anders Björklund | 165 | 769 | 84268 |
| Hua Zhang | 163 | 1503 | 116769 |
| Kaj Blennow | 160 | 1845 | 116237 |
| Leif Groop | 158 | 919 | 136056 |
| Tomas Hökfelt | 158 | 1033 | 95979 |
| Johan G. Eriksson | 156 | 1257 | 123325 |
| Naveed Sattar | 155 | 1326 | 116368 |
| Paul Elliott | 153 | 773 | 103839 |
| Claude Bouchard | 153 | 1076 | 115307 |
| Hakon Hakonarson | 152 | 968 | 101604 |