Institution
University of Jordan
Education•Amman, Jordan•
About: University of Jordan is a education organization based out in Amman, Jordan. It is known for research contribution in the topics: Population & Medicine. The organization has 7796 authors who have published 13764 publications receiving 213526 citations.
Topics: Population, Medicine, Health care, Computer science, Diabetes mellitus
Papers published on a yearly basis
Papers
More filters
••
TL;DR: An enhanced multi-objective SSA algorithm that adopts two essential components: the dynamic time-varying strategy and local fittest solutions that assist the SSAgorithm in balancing exploration and exploitation and converges faster while avoiding locally optimal solutions is proposed.
63 citations
••
21 Sep 2015-Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences
TL;DR: Rosmanol, cirsimaritin and salvigenin, all previously shown to have biphasic modulation of GABAA receptors, demonstrated CNS activity in mouse models of antinociception, antidepressant and anxiolysis.
Abstract: Purpose. Rosmarinus officinalis , traditionally known as rosemary, has been widely used in traditional medicines and has long been known as the herb of remembrance. However, few studies have investigated the effects of non-volatile components of rosemary on central nervous system function. Methods. Fractionation of R. officinalis led to the isolation of salvigenin, rosmanol and cirsimaritin, which were investigated in mouse models of acute toxicity, antinociception (tail immersion and hot plate tests), depression (tail suspension and forced swim tests) and anxiety (elevated plus maze and light/dark box paradigms). Results. Rosmanol, cirsimaritin and salvigenin were not found to exhibit any signs of acute toxicity (50-200 mg/kg), but elicited antinociceptive, antidepressant and anxiolytic activities. Conclusion. Rosmanol, cirsimaritin and salvigenin, all previously shown to have biphasic modulation of GABA A receptors, demonstrated CNS activity in mouse models of antinociception, antidepressant and anxiolysis. The anxiolytic activity of all three compounds was not ameliorated by flumazenil, but was inhibited by pentylenetetrazol, suggesting a mode of action via GABA A receptors at a site other than the high affinity benzodiazepine binding site. This article is open to POST-PUBLICATION REVIEW . Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
63 citations
••
TL;DR: An in-depth reflection and examination of different scenarios of the disease spread were developed and it is strongly recommended to promote community health awareness toward public health prevention and control measures, increase the efficiency and comprehensiveness of the epidemiological investigation and active and passive surveillance, and employ technology and digital health solutions to track cases and contacts.
Abstract: As of April 12, 2020, a total of 389 cases of coronavirus disease were confirmed in Jordan. To control this imminent threat, Jordan has enforced public health infection prevention and control measures, called for social distancing, seized all forms of inbound and outbound movement and international travel, and enacted the Defence Law that transferred the authority to the Minister of Defence to work and formulate orders according to the situation. In an effort to support the government in anticipating the requirements of the health system in the upcoming period, an in-depth reflection and examination of different scenarios of the disease spread were developed. This viewpoint suggests different strategies and measures for case detection and contact tracing, clinical management of cases, public health system functioning, and civil society organizations' contribution. It is necessary to accelerate containment of the disease to protect the economy and to maintain the continuity of some activities to mitigate the subsequent social, economic, and financial impacts. This requires finding a coping mechanism for a period that may be prolonged until laboratories develop a vaccine. Specifically, it is strongly recommended to promote community health awareness toward public health prevention and control measures, increase the efficiency and comprehensiveness of the epidemiological investigation and active and passive surveillance, and employ technology and digital health solutions to track cases and contacts. It is also recommended to increase and expand resources of intensive care units including respirators, increase the capacity and the number of trained health staff in the area of public health and epidemiology, ensure continued provision of essential public health programs, and mobilize the resources of nongovernmental sectors and donors to provide services for refugees and vulnerable populations.
63 citations
••
Charité1, Max Planck Society2, Agency for Science, Technology and Research3, Children's Hospital of Philadelphia4, Harvard University5, Oulu University Hospital6, University of Tennessee Health Science Center7, University Medical Center Groningen8, Ghent University Hospital9, United Arab Emirates University10, University of Washington11, University of Jordan12, University of Otago13, National University of Singapore14
TL;DR: Recurrent de novo mutations, affecting the highly conserved residue Arg138 of P5CS, cause an autosomal-dominant form of cutis laxa with progeroid features, which will have immediate impact on diagnostics and genetic counseling.
Abstract: Progeroid disorders overlapping with De Barsy syndrome (DBS) are collectively denoted as autosomal-recessive cutis laxa type 3 (ARCL3). They are caused by biallelic mutations in PYCR1 or ALDH18A1, encoding pyrroline-5-carboxylate reductase 1 and pyrroline-5-carboxylate synthase (P5CS), respectively, which both operate in the mitochondrial proline cycle. We report here on eight unrelated individuals born to non-consanguineous families clinically diagnosed with DBS or wrinkly skin syndrome. We found three heterozygous mutations in ALDH18A1 leading to amino acid substitutions of the same highly conserved residue, Arg138 in P5CS. A de novo origin was confirmed in all six probands for whom parental DNA was available. Using fibroblasts from affected individuals and heterologous overexpression, we found that the P5CS-p.Arg138Trp protein was stable and able to interact with wild-type P5CS but showed an altered sub-mitochondrial distribution. A reduced size upon native gel electrophoresis indicated an alteration of the structure or composition of P5CS mutant complex. Furthermore, we found that the mutant cells had a reduced P5CS enzymatic activity leading to a delayed proline accumulation. In summary, recurrent de novo mutations, affecting the highly conserved residue Arg138 of P5CS, cause an autosomal-dominant form of cutis laxa with progeroid features. Our data provide insights into the etiology of cutis laxa diseases and will have immediate impact on diagnostics and genetic counseling.
63 citations
••
TL;DR: The data suggest that the volatile oil of R. officinalis leaves has a calcium antagonistic property and inhibited the contractions of rabbit and guinea pig tracheal smooth muscle induced by acetylcholine and histamine stimulation, respectively, in Ca(2+)-free solution.
62 citations
Authors
Showing all 7905 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yousef Khader | 94 | 586 | 111094 |
Crispian Scully | 86 | 917 | 33404 |
Debra K. Moser | 85 | 558 | 27188 |
Pierre Thibault | 77 | 332 | 17741 |
Ali H. Nayfeh | 71 | 618 | 31111 |
Harold S. Margolis | 71 | 199 | 26719 |
Gerrit Hoogenboom | 69 | 560 | 24151 |
Shaher Momani | 64 | 301 | 13680 |
Robert McDonald | 62 | 577 | 17531 |
Kaarle Hämeri | 58 | 175 | 10969 |
James E. Maynard | 56 | 141 | 9158 |
E. Richard Moxon | 54 | 176 | 10395 |
Liam G Heaney | 53 | 234 | 8556 |
Stephen C. Hadler | 52 | 148 | 11458 |
Nicholas H. Oberlies | 52 | 262 | 9683 |