Showing papers by "University of North Carolina at Greensboro published in 2016"
01 Jan 2016
TL;DR: This chapter simplifies the Lagrangian support vector machine approach using process diagrams and data flow diagrams to help readers understand theory and implement it successfully.
Abstract: Support Vector Machine is one of the classical machine learning techniques that can still help solve big data classification problems. Especially, it can help the multidomain applications in a big data environment. However, the support vector machine is mathematically complex and computationally expensive. The main objective of this chapter is to simplify this approach using process diagrams and data flow diagrams to help readers understand theory and implement it successfully. To achieve this objective, the chapter is divided into three parts: (1) modeling of a linear support vector machine; (2) modeling of a nonlinear support vector machine; and (3) Lagrangian support vector machine algorithm and its implementations. The Lagrangian support vector machine with simple examples is also implemented using the R programming platform on Hadoop and non-Hadoop systems.
938 citations
TL;DR: This research suggests that creative thought involves dynamic interactions of large-scale brain systems, with the most compelling finding being that the default and executive control networks tend to cooperate during creative cognition and artistic performance.
626 citations
TL;DR: In this paper, the authors examined how political turnover affects corporate investment in a transitional economy and found that political turnover leads firms to significantly reduce corporate investment, particularly when the new official is an outsider appointed by a higher level government.
281 citations
01 Jan 2016
TL;DR: The 'ROS paradigm' is introduced so as to provide a conceptual framework for understanding the rapidly evolving field of ROS biology and medicine.
Abstract: Utilization of molecular oxygen by aerobic organisms inevitably results in the formation of a number of oxygen-containing reactive species that are collectively known as reactive oxygen species (ROS). ROS play important roles in both physiology and pathophysiology of aerobic life. The field of ‘ROS biology and medicine’ deals with the involvement of ROS and related species in contemporary biology and medicine. The purpose of this article is to survey common terms and concepts in ROS biology and medicine. It also introduces the ‘ROS paradigm’ so as to provide a conceptual framework for understanding the rapidly evolving field of ROS biology and medicine.
279 citations
17 May 2016
TL;DR: In this article, an exploratory study of science parks in the United States is presented, showing significant effects on growth for the proximity to universities and other resources, and there is a direct relationship between the proximity of the science park to the university and the probability that the academic curriculum will shift from basic toward applied research.
Abstract: "The paper is an exploratory study of science parks in the United States. It models the history of science parks as the diffusion of an innovation that was adopted at a rapid and increasing rate in the early 1980s, and since then at a decreased rate. It models the growth of a science park once established, showing significant effects on growth for the proximity to universities and other resources. The paper also reports university administrators’ perceptions about the impact of their science parks on the academic missions of their universities. Statistical analyses show there is a direct relationship between the proximity of the science park to the university and the probability that the academic curriculum will shift from basic toward applied research."
233 citations
TL;DR: The particular advantages of albumin used in DDSs include ready availability, ease of chemical modification, good biocompatibility, and low immunogenicity.
Abstract: One of the biggest impacts that the nanotechnology has made on medicine and biology, has been in the area of drug delivery systems (DDSs). Many drugs suffer from serious problems concerning insolubility, instability in biological environments, poor uptake into cells and tissues, sub-optimal selectivity for targets and unwanted side effects. Nanocarriers can be designed as DDSs to overcome many of these drawbacks. One of the most versatile building blocks to prepare these nanocarriers is the ubiquitous, readily available and inexpensive protein, serum albumin. Areas covered: This review covers the use of different types of albumin (human, bovine, rat, and chicken egg) to prepare nanoparticle and microparticle-based structures to bind drugs. Various methods have been used to modify the albumin structure. A range of targeting ligands can be attached to the albumin that can be recognized by specific cell receptors that are expressed on target cells or tissues. Expert opinion: The particular advantages of albumin used in DDSs include ready availability, ease of chemical modification, good biocompatibility, and low immunogenicity. The regulatory approvals that have been received for several albumin-based therapeutic agents suggest that this approach will continue to be successfully explored.
222 citations
TL;DR: A novel localization approach that utilizes the neighbor relative received signal strength to build the fingerprint database and adopts a Markov-chain prediction model to assist positioning is proposed.
Abstract: Location service is one of the primary services in smart automated systems of Internet of Things (IoT). For various location-based services, accurate localization has become a key issue. Recently, research on IoT localization systems for smart buildings has been attracting increasing attention. In this paper, we propose a novel localization approach that utilizes the neighbor relative received signal strength to build the fingerprint database and adopts a Markov-chain prediction model to assist positioning. The approach is called the novel localization method (LNM) in short. In the proposed LNM scheme, the history data of the pedestrian’s locations are analyzed to further lower the unpredictable signal fluctuations in a smart building environment, meanwhile enabling calibration-free positioning for various devices. The performance evaluation conducted in a realistic environment shows that the presented method demonstrates superior localization performance compared with well-known existing schemes, especially when the problems of device heterogeneity and WiFi signals fluctuation exist.
212 citations
University of Pretoria1, Centraalbureau voor Schimmelcultures2, Murdoch University3, Rovira i Virgili University4, Stellenbosch University5, Laos Ministry of Agriculture and Forestry6, Spanish National Research Council7, Federal University of Rio Grande do Norte8, Universidade Federal de Viçosa9, Chiang Mai University10, Federal University of Pernambuco11, University of Alcalá12, University of Texas Health Science Center at San Antonio13, James Cook University14, Universidade Federal de Santa Maria15, Pennsylvania State University16, University of Tabriz17, University of Angers18, Sao Paulo State University19, State University of Feira de Santana20, University of Geneva21, La Trobe University22, Hosei University23, Universidad Autónoma de Chiriquí24, Slovak National Museum25, University of Ottawa26, Charles University in Prague27, University of Gothenburg28, University of Calicut29, Empresa Brasileira de Pesquisa Agropecuária30, University of Illinois at Urbana–Champaign31, University of the Basque Country32, Goethe University Frankfurt33, University of North Carolina at Greensboro34, University of Sydney35, University of Arkansas System36, University of Turin37, Federal University of Paraíba38, Complutense University of Madrid39
TL;DR: Novel species of fungi described in this study include those from various countries as follows: Apiognomonia lasiopetali on Lasiopetalum sp.
Abstract: Novel species of fungi described in this study include those from various countries as follows: Australia: Apiognomonia lasiopetali on Lasiopetalum sp., Blastacervulus eucalyptorum on Eucalyptus adesmophloia, Bullanockia australis (incl. Bullanockia gen. nov.) on Kingia australis, Caliciopsis eucalypti on Eucalyptus marginata, Celerioriella petrophiles on Petrophile teretifolia, Coleophoma xanthosiae on Xanthosia rotundifolia, Coniothyrium hakeae on Hakea sp., Diatrypella banksiae on Banksia formosa, Disculoides corymbiae on Corymbia calophylla, Elsinoe eelemani on Melaleuca alternifolia, Elsinoe eucalyptigena on Eucalyptus kingsmillii, Elsinoe preissianae on Eucalyptus preissiana, Eucasphaeria rustici on Eucalyptus creta, Hyweljonesia queenslandica (incl. Hyweljonesia gen. nov.) on the cocoon of an unidentified microlepidoptera, Mycodiella eucalypti (incl. Mycodiella gen. nov.) on Eucalyptus diversicolor, Myrtapenidiella sporadicae on Eucalyptus sporadica, Neocrinula xanthorrhoeae (incl. Neocrinula gen. nov.) on Xanthorrhoea sp., Ophiocordyceps nooreniae on dead ant, Phaeosphaeriopsis agavacearum on Agave sp., Phlogicylindrium mokarei on Eucalyptus sp., Phyllosticta acaciigena on Acacia suaveolens, Pleurophoma acaciae on Acacia glaucoptera, Pyrenochaeta hakeae on Hakea sp., Readeriella lehmannii on Eucalyptus lehmannii, Saccharata banksiae on Banksia grandis, Saccharata daviesiae on Daviesia pachyphylla, Saccharata eucalyptorum on Eucalyptus bigalerita, Saccharata hakeae on Hakea baxteri, Saccharata hakeicola on Hakea victoria, Saccharata lambertiae on Lambertia ericifolia, Saccharata petrophiles on Petrophile sp., Saccharata petrophilicola on Petrophile fastigiata, Sphaerellopsis hakeae on Hakea sp., and Teichospora kingiae on Kingia australis. Brazil: Adautomilanezia caesalpiniae (incl. Adautomilanezia gen. nov.) on Caesalpina echinata, Arthrophiala arthrospora (incl. Arthrophiala gen. nov.) on Sagittaria montevidensis, Diaporthe caatingaensis (endophyte from Tacinga inamoena), Geastrum ishikawae on sandy soil, Geastrum pusillipilosum on soil, Gymnopus pygmaeus on dead leaves and sticks, Inonotus hymenonitens on decayed angiosperm trunk, Pyricularia urashimae on Urochloa brizantha, and Synnemellisia aurantia on Passiflora edulis. Chile: Tubulicrinis australis on Lophosoria quadripinnata. France: Cercophora squamulosa from submerged wood, and Scedosporium cereisporum from fluids of a wastewater treatment plant. Hawaii: Beltraniella acaciae, Dactylaria acaciae, Rhexodenticula acaciae, Rubikia evansii and Torula acaciae (all on Acacia koa). India: Lepidoderma echinosporum on dead semi-woody stems, and Rhodocybe rubrobrunnea from soil. Iran: Talaromyces kabodanensis from hypersaline soil. La Reunion: Neocordana musarum from leaves of Musa sp. Malaysia: Anungitea eucalyptigena on Eucalyptus grandis × pellita, Camptomeriphila leucaenae (incl. Camptomeriphila gen. nov.) on Leucaena leucocephala, Castanediella communis on Eucalyptus pellita, Eucalyptostroma eucalypti (incl. Eucalyptostroma gen. nov.) on Eucalyptus pellita, Melanconiella syzygii on Syzygium sp., Mycophilomyces periconiae (incl. Mycophilomyces gen. nov.) as hyperparasite on Periconia on leaves of Albizia falcataria, Synnemadiella eucalypti (incl. Synnemadiella gen. nov.) on Eucalyptus pellita, and Teichospora nephelii on Nephelium lappaceum. Mexico: Aspergillus bicephalus from soil. New Zealand: Aplosporella sophorae on Sophora microphylla, Libertasomyces platani on Platanus sp., Neothyronectria sophorae (incl. Neothyronectria gen. nov.) on Sophora microphylla, Parastagonospora phoenicicola on Phoenix canariensis, Phaeoacremonium pseudopanacis on Pseudopanax crassifolius, Phlyctema phoenicis on Phoenix canariensis, and Pseudoascochyta novae-zelandiae on Cordyline australis. Panama: Chalara panamensis from needle litter of Pinus cf. caribaea. South Africa: Exophiala eucalypti on leaves of Eucalyptus sp., Fantasmomyces hyalinus (incl. Fantasmomyces gen. nov.) on Acacia exuvialis, Paracladophialophora carceris (incl. Paracladophialophora gen. nov.) on Aloe sp., and Umthunziomyces hagahagensis (incl. Umthunziomyces gen. nov.) on Mimusops caffra. Spain: Clavaria griseobrunnea on bare ground in Pteridium aquilinum field, Cyathus ibericus on small fallen branches of Pinus halepensis, Gyroporus pseudolacteus in humus of Pinus pinaster, and Pseudoascochyta pratensis (incl. Pseudoascochyta gen. nov.) from soil. Thailand: Neoascochyta adenii on Adenium obesum, and Ochroconis capsici on Capsicum annuum. UK: Fusicolla melogrammae from dead stromata of Melogramma campylosporum on bark of Carpinus betulus. Uruguay: Myrmecridium pulvericola from house dust. USA: Neoscolecobasidium agapanthi (incl. Neoscolecobasidium gen. nov.) on Agapanthus sp., Polyscytalum purgamentum on leaf litter, Pseudopithomyces diversisporus from human toenail, Saksenaea trapezispora from knee wound of a soldier, and Sirococcus quercus from Quercus sp. Morphological and culture characteristics along with DNA barcodes are provided.
199 citations
TL;DR: In this paper, the role of sociocultural interfirm linkages, HR flexibility, and organizational cultural differences in M&As are further elucidated, and it is argued that HR flexibility (flexibility in employee skills, flexibility in employee behavior, and flexibility in HR practices) is vital for the development of the above-mentioned soci-ocultural links.
180 citations
01 Jan 2016
TL;DR: The main objective of this chapter is to introduce you to hierarchical supervised learning models, one of the main hierarchical models is the decision tree, which has two categories: classification tree and regression tree.
Abstract: The main objective of this chapter is to introduce you to hierarchical supervised learning models. One of the main hierarchical models is the decision tree. It has two categories: classification tree and regression tree. The theory and applications of these decision trees are explained in this chapter. These techniques require tree split algorithms to build the decision trees and require quantitative measures to build an efficient tree via training. Hence, the chapter dedicates some discussion to the measures like entropy, cross-entropy, Gini impurity, and information gain. It also discusses the training algorithms suitable for classification tree and regression tree models. Simple examples and visual aids explain the difficult concepts so that readers can easily grasp the theory and applications of decision tree.
164 citations
TL;DR: In this paper, a multi-method approach examines the perceived motivations that impact consumers' willingness to access products through socially networked short-term rentals and reveals four distinct groups of consumers with varying dispositions toward access-based consumption: Fickle Floaters, Premium Keepers, Conscious Materialists and Change Seekers.
TL;DR: The authors evaluated the extent to which political boundaries are suitable for clustering cultures based on a meta-analysis of 558 studies that used Hofstede's (Culture's consequences: international differences in work-related values) cultural values framework.
Abstract: Traditionally, cultures have been treated as though they reside exclusively within, or perfectly overlap with countries. Indeed, the terms “country” and “culture” are often used interchangeably. As evidence mounts for substantial within-country cultural variation, and often between-country similarities, the problem with equating country and culture becomes more apparent. To help resolve the country-culture conundrum, we evaluate the extent to which political boundaries are suitable for clustering cultures based on a meta-analysis of 558 studies that used Hofstede’s (Culture’s consequences: international differences in work-related values. Sage Publications, Beverly Hills, 1980) cultural values framework. The results reveal that approximately 80 % of variation in cultural values resides within countries, confirming that country is often a poor proxy for culture. We also evaluate the relative suitability of other demographic and environmental characteristics, such as occupation, socio-economic status, wealth, freedom, globalization, and instability. Our results suggest that it may be more appropriate to talk about cultures of professions, socio-economic classes, and free versus oppressed societies, than about cultures of countries.
TL;DR: A detailed technological study is provided and evidence of the use of these tools on the butchery and consumption of fauna, probably by early Homo erectus sensu lato is provided, showing that complex cognition was present from the earliest stages of the Acheulean.
Abstract: The appearance of the Acheulean is one of the hallmarks of human evolution. It represents the emergence of a complex behavior, expressed in the recurrent manufacture of large-sized tools, with standardized forms, implying more advance forethought and planning by hominins than those required by the precedent Oldowan technology. The earliest known evidence of this technology dates back to c. 1.7 Ma. and is limited to two sites (Kokiselei [Kenya] and Konso [Ethiopia]), both of which lack functionally-associated fauna. The functionality of these earliest Acheulean assemblages remains unknown. Here we present the discovery of another early Acheulean site also dating to c. 1.7 Ma from Olduvai Gorge. This site provides evidence of the earliest steps in developing the Acheulean technology and is the oldest Acheulean site in which stone tools occur spatially and functionally associated with the exploitation of fauna. Simple and elaborate large-cutting tools (LCT) and bifacial handaxes co-exist at FLK West, showing that complex cognition was present from the earliest stages of the Acheulean. Here we provide a detailed technological study and evidence of the use of these tools on the butchery and consumption of fauna, probably by early Homo erectus sensu lato.
TL;DR: Using structural equation modeling and graph theoretical analysis of resting‐state fMRI data, evidence is provided that Openness to Experience—a normally distributed personality trait reflecting a tendency to engage in imaginative, creative, and abstract cognitive processes—underlies efficiency of information processing within the brain's default network.
Abstract: The brain's default network (DN) has been a topic of considerable empirical interest. In fMRI research, DN activity is associated with spontaneous and self-generated cognition, such as mind-wandering, episodic memory retrieval, future thinking, mental simulation, theory of mind reasoning, and creative cognition. Despite large literatures on developmental and disease-related influences on the DN, surprisingly little is known about the factors that impact normal variation in DN functioning. Using structural equation modeling and graph theoretical analysis of resting-state fMRI data, we provide evidence that Openness to Experience-a normally distributed personality trait reflecting a tendency to engage in imaginative, creative, and abstract cognitive processes-underlies efficiency of information processing within the DN. Across two studies, Openness predicted the global efficiency of a functional network comprised of DN nodes and corresponding edges. In Study 2, Openness remained a robust predictor-even after controlling for intelligence, age, gender, and other personality variables-explaining 18% of the variance in DN functioning. These findings point to a biological basis of Openness to Experience, and suggest that normally distributed personality traits affect the intrinsic architecture of large-scale brain systems. Hum Brain Mapp 37:773-779, 2016. © 2015 Wiley Periodicals, Inc.
TL;DR: In this article, the authors compare specific factors that may influence wine tourists' intentions to visit or revisit a winery or wine region in North Carolina and determine the role of winescape and tourism services in promoting wine tourism.
University of Washington1, Uniformed Services University of the Health Sciences2, University of North Carolina at Greensboro3, Georgia Southern University4, University of South Carolina5, Carolinas Healthcare System6, University of Texas Southwestern Medical Center7, University of Wisconsin-Madison8, University of Minnesota9
TL;DR: It is the individual physician's assessment in the context of an emerging evidence base that the chosen model for early detection of cardiac disorders in the specific population provides greater benefit than harm.
Abstract: Cardiovascular screening in young athletes is widely recommended and routinely performed prior to participation in competitive sports. While there is general agreement that early detection of cardiac conditions at risk for sudden cardiac arrest and death (SCA/D) is an important objective, the optimal strategy for cardiovascular screening in athletes remains an issue of considerable debate. At the centre of the controversy is the addition of a resting ECG to the standard preparticipation evaluation using history and physical examination. The American Medical Society for Sports Medicine (AMSSM) formed a task force to address the current evidence and knowledge gaps regarding preparticipation cardiovascular screening in athletes from the perspective of a primary care sports medicine physician. The absence of definitive outcome-based evidence at this time precludes AMSSM from endorsing any single or universal cardiovascular screening strategy for all athletes, including legislative mandates. This statement presents a new paradigm to assist the individual physician in assessing the most appropriate cardiovascular screening strategy unique to their athlete population, community needs and resources. The decision to implement a cardiovascular screening programme, with or without the addition of ECG, necessitates careful consideration of the risk of SCA/D in the targeted population and the availability of cardiology resources and infrastructure. Importantly, it is the individual physician's assessment in the context of an emerging evidence base that the chosen model for early detection of cardiac disorders in the specific population provides greater benefit than harm. AMSSM is committed to advancing evidenced-based research and educational initiatives that will validate and promote the most efficacious strategies to foster safe sport participation and reduce SCA/D in athletes.
TL;DR: A theoretical review published in 2009 revealed that scholars who stated that their research was based on Urie Bronfenbrenner's bio-ecological theory of human development rarely used it appropriately as discussed by the authors.
Abstract: A theoretical review published in 2009 revealed that scholars who stated that their research was based on Urie Bronfenbrenner's bioecological theory of human development rarely used it appropriately. To what extent has the situation changed since then? We used the same methods to identify relevant articles as had been used in the 2009 article and found 20 publications whose authors explicitly claimed that Bronfenbrenner provided the theoretical foundation for their study. Although 18 of those publications included citations to the mature (mid-1990s) version of Bronfenbrenner's theory, only two appropriately described, tested, and evaluated the four major concepts of Bronfenbrenner's theory—proximal processes, person characteristics, context, and time. Failure either to correctly describe the theory or to critically test its central concepts poses significant problems for the future of family studies and developmental science. We discuss potential ways to improve this situation through metatheoretical, methodological, and pedagogical reflections.
TL;DR: In this article, the authors identify key motives behind organic food purchase intention of older consumers, including food safety concerns, environmental concerns, and ethical consumer-identity, in order to investigate its relative importance in older consumers' behavioral intentions.
TL;DR: It is indicated that indirect exposure can lead to PTSD, although the probability of developing the disorder from indirect exposure is lower than that from direct exposure, and proximity as a risk factor for PTSD.
Abstract: OBJECTIVE: The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) includes significant changes to Criterion A for posttraumatic stress disorder (PTSD), the criterion that defines which events qualify as "traumatic." This systematic review explores the fundamental question of how to define a trauma by reviewing the difference between direct and indirect trauma exposure and the risk for PTSD associated with both exposure types. Direct exposure includes experiencing a trauma firsthand or witnessing a trauma as it occurs to others. In contrast, indirect exposure may occur by learning about the violent or accidental death of a close associate, through secondary narrative accounts (e.g., in service-related professions), or through work-related media reports. This review examines whether indirect trauma exposure can lead to PTSD and the role of proximity in symptom development. METHOD: We conducted a systematic review of the research assessing changes to PTSD Criterion A in DSM-5, various levels of traumatic exposure, and proximity as a risk factor for PTSD. RESULTS: Our review indicates that indirect exposure can lead to PTSD, although the probability of developing the disorder from indirect exposure is lower than that from direct exposure. Proximity to a trauma also increases risk, but this may be limited to direct exposure. CONCLUSIONS: Knowledge of the impact of level of exposure (direct vs. indirect) and proximity will help to better define what events meet PTSD Criterion A. Future research is needed to examine DSM-5's requirement that exposure through media must be related to one's work. (PsycINFO Database Record Language: en
TL;DR: This first comprehensive study on impacts of migratory management on the health and oxidative stress of honey bees found that migration affected oxidative stress levels in honey bees, but that food scarcity had an even larger impact; some detrimental effects of migration may be alleviated by a greater abundance of forage.
Abstract: Migratory management and environmental conditions affect lifespan and oxidative stress in honey bees
TL;DR: The potential of biochemometrics coupled with bioassay-guided fractionation to identify bioactive mixture components is demonstrated, demonstrating the ability to integrate multiple stages of fractionation and bioassays data into a single analysis.
Abstract: A central challenge of natural products research is assigning bioactive compounds from complex mixtures. The gold standard approach to address this challenge, bioassay-guided fractionation, is often biased toward abundant, rather than bioactive, mixture components. This study evaluated the combination of bioassay-guided fractionation with untargeted metabolite profiling to improve active component identification early in the fractionation process. Key to this methodology was statistical modeling of the integrated biological and chemical data sets (biochemometric analysis). Three data analysis approaches for biochemometric analysis were compared, namely, partial least-squares loading vectors, S-plots, and the selectivity ratio. Extracts from the endophytic fungi Alternaria sp. and Pyrenochaeta sp. with antimicrobial activity against Staphylococcus aureus served as test cases. Biochemometric analysis incorporating the selectivity ratio performed best in identifying bioactive ions from these extracts early in the fractionation process, yielding altersetin (3, MIC 0.23 μg/mL) and macrosphelide A (4, MIC 75 μg/mL) as antibacterial constituents from Alternaria sp. and Pyrenochaeta sp., respectively. This study demonstrates the potential of biochemometrics coupled with bioassay-guided fractionation to identify bioactive mixture components. A benefit of this approach is the ability to integrate multiple stages of fractionation and bioassay data into a single analysis.
TL;DR: The fact that WMC tends to strongly predict analytical problem solving and reasoning, but may not correlate with divergent thinking, provides a useful boundary condition for defining WMC's nomological net.
Abstract: Should executive control, as indicated by working memory capacity (WMC) and mind-wandering propensity, help or hinder creativity? Sustained and focused attention should help guide a selective search of solution-relevant information in memory and help inhibit uncreative, yet accessible, ideas. However, unfocused attention and daydreaming should allow mental access to more loosely relevant concepts, remotely linked to commonplace solutions. Three individual-differences studies inserted incubation periods into 1 or 2 divergent thinking tasks and tested whether WMC (assessed by complex span tasks) and incubation-period mind wandering (assessed as probed reports of task-unrelated thought [TUT]) predicted postincubation performance. Retrospective self-reports of Openness (Experiment 2) and mind-wandering and daydreaming propensity (Experiment 3) complemented our thought-probe assessments of TUT. WMC did not correlate with creativity in divergent thinking, whereas only the questionnaire measure of daydreaming, but not probed thought reports, weakly predicted creativity; the fact that in-the-moment TUTs did not correlate with divergent creativity is especially problematic for claims that mind-wandering processes contribute to creative cognition. Moreover, the fact that WMC tends to strongly predict analytical problem solving and reasoning, but may not correlate with divergent thinking, provides a useful boundary condition for defining WMC’s nomological net. On balance, our data provide no support for either benefits or costs of executive control for at least 1 component of creativity.
01 Sep 2016
TL;DR: This ROS Protocols article described the flow cytometric protocol involving the use of various concentrations of MitoSOX (1, 2.5, 5 μM) for detecting mitochondrial ROS in control and mitochondrial DNA-deficient melanoma B16-F10 cells and suggested that 1 μM, rather than the commonly used 5μM, appeared to be the optimal concentration.
Abstract: MitoSOX-based assays are widely used to detect mitochondrial reactive oxygen species (ROS), especially superoxide. To this end, 5 µM MitoSOX is commonly used. In this ROS Protocols article, we described the flow cytometric protocol involving the use of various concentrations of MitoSOX (1, 2.5, 5 µM) for detecting mitochondrial ROS in control and mitochondrial DNA-deficient (MD) melanoma B16-F10 cells. We also compared the MitoSOX-based flow cytometry with lucigenin-derived chemiluminometry for their ability to reliably detect the relative differences in mitochondrial ROS formation in the control and MD cells. Our results suggested that 1 µM, rather than the commonly used 5 µM, appeared to be the optimal concentration of MitoSOX for detecting mitochondrial ROS via flow cytometry.
TL;DR: Several promising biologically active lead compounds from each major organism class investigated are described, and these may be seen to be representative of a very wide chemical diversity.
Abstract: Recent progress is described in an ongoing collaborative multidisciplinary research project directed towards the purification, structural characterization, chemical modification, and biological evaluation of new potential natural product anticancer agents obtained from a diverse group of organisms, comprising tropical plants, aquatic and terrestrial cyanobacteria, and filamentous fungi Information is provided on how these organisms are collected and processed The types of bioassays are indicated in which initial extracts, chromatographic fractions, and purified isolated compounds of these acquisitions are tested Several promising biologically active lead compounds from each major organism class investigated are described, and these may be seen to be representative of a very wide chemical diversity
TL;DR: The results indicated that higher quality maternal behavior during mother-infant interactions predicted higher frontal resting EEG power at 10 and 24 months, as well as increases in power between 5 and 10 Months, and between 10 and24 months.
Abstract: The aim of this study was to investigate if normative variations in parenting relate to brain development among typically developing children. A sample of 352 mother-infant dyads came to the laboratory when infants were 5, 10, and 24 months of age (final N = 215). At each visit, child resting electroencephalography (EEG) was recorded. Mother-infant interactions were videotaped at the 5-month visit. The results indicated that higher quality maternal behavior during mother-infant interactions predicted higher frontal resting EEG power at 10 and 24 months, as well as increases in power between 5 and 10 months, and between 10 and 24 months. These findings provide rare support for the hypothesis that normative variation in parenting quality may contribute to brain development among typically developing infants.
TL;DR: In this article, a meta-analysis synthesized the literature on parent-adolescent conflict and distinguished disagreement, hostility, and composite measures of disagreement and hostility, concluding that both disagreement and aggression in parent-student relationships have negative effects on youth development.
Abstract: Parent–adolescent conflict is a normative characteristic of adolescence. However, research findings have been inconsistent, and the relative contributions of specific dimensions of parent–adolescent conflict (disagreement and hostility) to youth maladjustment are unknown. This meta-analysis synthesized the literature on parent–adolescent conflict and distinguished disagreement, hostility, and composite measures of disagreement and hostility. A multilevel model was utilized to analyze 401 effects from 52 studies. Results indicate that parent–adolescent conflict is positively associated with youth maladjustment. The strength of this association varied as a function of youth maladjustment dimensions but not conflict dimensions. The association between parent–adolescent conflict and youth maladjustment also varied by youth gender and by longitudinal versus cross-sectional design. Results suggest that both disagreement and hostility in parent–adolescent relationships have negative effects on youth development.
TL;DR: In this article, the authors examined the influence of cultural values on conflict handling styles through emotional intelligence and found that uncertainty avoidance and long-term orientation influence preferences for the conflict handling style of compromising, obliging, and integrating, while power distance has a direct positive effect on the preference for an avoiding and a dominating style.
TL;DR: The findings shed further light on the roles of inferior and superior parietal cortex for internally directed cognition and the mechanism for shielding ongoing internal processes from potentially distracting sensory stimulation in terms of perceptual decoupling is disentangled.
Abstract: Internal cognition like imagination and prospection require sustained internally directed attention and involve self-generated thought. This fMRI study aimed to disentangle the brain mechanisms associated with attention-specific and task-specific processes during internally directed cognition. The direction of attention was manipulated by either keeping a relevant stimulus visible throughout the task, or by masking it, so that the task had to be performed “in the mind’s eye”. The level of self-directed thought was additionally varied between a convergent and a divergent thinking task. Internally directed attention was associated with increased activation in the right anterior inferior parietal lobe (aIPL), bilateral lingual gyrus and the cuneus, as well as with extended deactivations of superior parietal and occipital regions representing parts of the dorsal attention network. The right aIPL further showed increased connectivity with occipital regions suggesting an active top-down mechanism for shielding ongoing internal processes from potentially distracting sensory stimulation in terms of perceptual decoupling. Activation of the default network was not related to internally directed attention per se, but rather to a higher level of self-generated thought. The findings hence shed further light on the roles of inferior and superior parietal cortex for internally directed cognition.
TL;DR: In this paper, the authors argue that the process theory of Alfred North Whitehead best explains why entrepreneurship education does not always have the same results on our students in the classroom and after they graduate.
TL;DR: RT is an efficacious intervention strategy for improving LP and KE muscle power in adults aged ≥50 years and should be considered when prescribing RT exercise for middle-aged and older adults.
Abstract: Resistance training (RT) has been investigated as a potential intervention strategy for improving muscle function, but the effects on lower-extremity muscle power in middle-aged and older adults have not been systematically reviewed. The aim of this meta-analysis is to provide a quantitative estimate of the effect of RT on lower-extremity muscle power in middle-aged and older adults and to examine independent moderators of this relationship. Randomized controlled trials that examined the effects of RT on either leg press (LP) or knee extension (KE) muscle power in adults aged ≥50 years were included. Data were aggregated with meta-analytic techniques, and multi-level modeling was used to adjust for nesting effects. A total of 52 effects from 12 randomized controlled trials were analyzed with a random-effects model to estimate the effect of RT on lower-extremity muscle power. A multiple-regression analysis was conducted to examine independent moderators of the mean effect. The adjusted aggregated results from all studies indicate that RT has a small-to-moderate effect on lower-extremity muscle power (Hedges’ d = 0.34, 95 % confidence interval [CI] 0.25–0.43), which translated to 54.90 watts (95 % CI 40.37–69.43). Meta-regression analyses indicated that high-velocity RT was superior to traditional RT (Δ = 0.62 vs. 0.20, respectively) for increasing lower-extremity muscle power. In addition, training volume significantly moderated the effect of RT on muscle power. The findings from this meta-analysis indicate that RT is an efficacious intervention strategy for improving LP and KE muscle power in adults aged ≥50 years. Training mode and volume independently moderate the effect of RT on lower-extremity muscle power, and should be considered when prescribing RT exercise for middle-aged and older adults.