Institution
University of Oviedo
Education•Oviedo, Spain•
About: University of Oviedo is a education organization based out in Oviedo, Spain. It is known for research contribution in the topics: Population & Catalysis. The organization has 13423 authors who have published 31649 publications receiving 844799 citations. The organization is also known as: Universidá d'Uviéu & Universidad de Oviedo.
Papers published on a yearly basis
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University of Oxford1, Australian National University2, Queen's University Belfast3, University of Maryland, College Park4, University of the Basque Country5, Autonomous University of Madrid6, University of Siena7, Centre national de la recherche scientifique8, University of Tübingen9, University of La Laguna10, University of Cantabria11, University of Trento12, Royal Belgian Institute of Natural Sciences13, University of Massachusetts Amherst14, University of Arizona15, National University of Distance Education16, Weizmann Institute of Science17, Trent University18, University of Genoa19, University of Ferrara20, University of Oviedo21, Université de Montréal22, University College Dublin23, Natural History Museum24
TL;DR: Improved accelerator mass spectrometry 14C techniques are applied to construct robust chronologies from 40 key Mousterian and Neanderthal archaeological sites, showing that there was ample time for the transmission of cultural and symbolic behaviours, as well as possible genetic exchanges, between the two groups.
Abstract: The timing of Neanderthal disappearance and the extent to which they overlapped with the earliest incoming anatomically modern humans (AMHs) in Eurasia are key questions in palaeoanthropology. Determining the spatiotemporal relationship between the two populations is crucial if we are to understand the processes, timing and reasons leading to the disappearance of Neanderthals and the likelihood of cultural and genetic exchange. Serious technical challenges, however, have hindered reliable dating of the period, as the radiocarbon method reaches its limit at ∼50,000 years ago. Here we apply improved accelerator mass spectrometry (14)C techniques to construct robust chronologies from 40 key Mousterian and Neanderthal archaeological sites, ranging from Russia to Spain. Bayesian age modelling was used to generate probability distribution functions to determine the latest appearance date. We show that the Mousterian ended by 41,030-39,260 calibrated years bp (at 95.4% probability) across Europe. We also demonstrate that succeeding 'transitional' archaeological industries, one of which has been linked with Neanderthals (Châtelperronian), end at a similar time. Our data indicate that the disappearance of Neanderthals occurred at different times in different regions. Comparing the data with results obtained from the earliest dated AMH sites in Europe, associated with the Uluzzian technocomplex, allows us to quantify the temporal overlap between the two human groups. The results reveal a significant overlap of 2,600-5,400 years (at 95.4% probability). This has important implications for models seeking to explain the cultural, technological and biological elements involved in the replacement of Neanderthals by AMHs. A mosaic of populations in Europe during the Middle to Upper Palaeolithic transition suggests that there was ample time for the transmission of cultural and symbolic behaviours, as well as possible genetic exchanges, between the two groups.
605 citations
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07 May 2008-Methodology: European Journal of Research Methods for The Behavioral and Social Sciences
TL;DR: In this paper, the authors determine in a systematic fashion the number of response alternatives that maximizes the fundamental psychometric properties of a scale: reliability and validity, with data simulated using the Monte Carlo method.
Abstract: The Likert-type format is one of the most widely used in all types of scales in the field of social sciences. Nevertheless, there is no definitive agreement on the number of response categories that optimizes the psychometric properties of the scales. The aim of the present work is to determine in a systematic fashion the number of response alternatives that maximizes the fundamental psychometric properties of a scale: reliability and validity. The study is carried out with data simulated using the Monte Carlo method. We simulate responses to 30 items with correlations between them ranging from 0.2 to 0.9. We also manipulate sample size, analyzing four different sizes: 50, 100, 200, and 500 cases. The number of response options employed ranges from two to nine. The results show that as the number of response alternatives increases, both reliability and validity improve. The optimum number of alternatives is between four and seven. With fewer than four alternatives the reliability and validity decrease, an...
603 citations
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National Autonomous University of Mexico1, National University of Comahue2, University of Jaén3, University of Seville4, National University of Cordoba5, Sao Paulo State University6, Spanish National Research Council7, University of Oviedo8, University of Granada9, University of Chile10, University of Vigo11, Central University of Venezuela12
TL;DR: A novel model proposes a novel approach that relates the diversity of both species and interactions along a gradient of environmental deterioration and explores how the rate of loss of ecological functions, and consequently of ecosystem services, can be accelerated or restrained depending on how the rates of species loss covaries with the rateof interactions loss.
Abstract: Summary 1. The effects of the present biodiversity crisis have been largely focused on the loss of species. However, a missed component of biodiversity loss that often accompanies or even precedes species disappearance is the extinction of ecological interactions. 2. Here, we propose a novel model that (i) relates the diversity of both species and interactions along a gradient of environmental deterioration and (ii) explores how the rate of loss of ecological functions, and consequently of ecosystem services, can be accelerated or restrained depending on how the rate of species loss covaries with the rate of interactions loss. 3. We find that the loss of species and interactions are decoupled, such that ecological interactions are often lost at a higher rate. This implies that the loss of ecological interactions may occur well before species disappearance, affecting species functionality and ecosystems services at a faster rate than species extinctions. We provide a number of empirical case studies illustrating these points. 4. Our approach emphasizes the importance of focusing on species interactions as the major biodiversity component from which the ‘health’ of ecosystems depends.
603 citations
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TL;DR: In the last two decades, new MNEs from emerging, upper-middle-income, or oil-rich countries have followed completely different patterns of international expansion as mentioned in this paper, and to what extent we need a new theory to explain their international growth.
Abstract: Executive Overview The traditional American model of multinational enterprise (MNE), characterized by foreign direct investment (FDI) aimed at exploiting firm-specific capabilities developed at home and a gradual country-by-country approach of internationalization, dominated the global economy during much of the post-World War II period. In the last two decades, however, new MNEs from emerging, upper-middle-income, or oil-rich countries have followed completely different patterns of international expansion. In this paper we analyze the processes through which these firms became MNEs and to what extent we need a new theory to explain their international growth.
595 citations
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TL;DR: A better understanding of the functional complexity of this proteolytic system and global approaches to identify the relevant MMPs which must be targeted in each individual cancer patient, will be necessary to clarify whether MMP inhibition may be part of future therapies against cancer.
Abstract: Over the last years, the relevance of the matrix metalloproteinase (MMP) family in cancer research has grown considerably. These enzymes were initially associated with the invasive properties of tumour cells, owing to their ability to degrade all major protein components of the extracellular matrix (ECM) and basement membranes. However, further studies have demonstrated the implication of MMPs in early steps of tumour evolution, including stimulation of cell proliferation and modulation of angiogenesis. The establishment of causal relationships between MMP overproduction in tumour or stromal cells and cancer progression has prompted the development of clinical trials with a series of inhibitors designed to block the proteolytic activity of these enzymes. Unfortunately, the results derived from using broad-spectrum MMP inhibitors (MMPIs) for treating patients with advanced cancer have been disappointing in most cases. There are several putative explanations for the lack of success of these MMPIs including the recent finding that some MMPs may play a paradoxical protective role in tumour progression. These observations together with the identification of novel functions for MMPs in early stages of cancer have made necessary a reformulation of MMP inhibition strategies. A better understanding of the functional complexity of this proteolytic system and global approaches to identify the relevant MMPs which must be targeted in each individual cancer patient, will be necessary to clarify whether MMP inhibition may be part of future therapies against cancer.
595 citations
Authors
Showing all 13643 results
Name | H-index | Papers | Citations |
---|---|---|---|
Russel J. Reiter | 169 | 1646 | 121010 |
Carlo Rovelli | 146 | 1502 | 103550 |
J. González-Nuevo | 144 | 500 | 108318 |
German Martinez | 141 | 1476 | 107887 |
Roland Horisberger | 139 | 1471 | 100458 |
Francisco Herrera | 139 | 1001 | 82976 |
Javier Cuevas | 138 | 1689 | 103604 |
Teresa Rodrigo | 138 | 1831 | 103601 |
L. Toffolatti | 136 | 376 | 95529 |
Elias Campo | 135 | 761 | 85160 |
Gabor Istvan Veres | 135 | 1349 | 96104 |
Francisco Matorras | 134 | 1428 | 94627 |
Joe Incandela | 134 | 1549 | 93750 |
Nikhil C. Munshi | 134 | 906 | 67349 |
Luca Scodellaro | 134 | 1741 | 98331 |